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C) Internship in Research

C) Internship in Research. Arylation of trimethylvinylsilane. Synthesis of (E) -1-iodo-2-arylethylenes and of (E,E)- 1,4-diarylbuta-1,3-dienes by Heck reaction Supervisor : Dr Jeffery Laboratoire de Synthèse Organique Sélective et Chimie Organométallique February to July 2004.

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C) Internship in Research

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  1. C) Internship in Research Arylation of trimethylvinylsilane.Synthesis of (E)-1-iodo-2-arylethylenes and of (E,E)-1,4-diarylbuta-1,3-dienes by Heck reaction Supervisor : Dr Jeffery Laboratoire de Synthèse Organique Sélective et Chimie Organométallique February to July 2004

  2. Objectives : syntheses of diarylbutadienes Heck reaction Heck reaction Heck reaction

  3. Heck reaction Heck, R. F. Org. React. 1982, 27, 345-390

  4. Arylation of trimethylvinylsilane • Addition of R4N+X- : • reaction are faster and more selective • Choice of catalytic system[Pd/Base/QX] can change the selectivity Jeffery, T. Tetrahedron Lett. 2000, 41, 8445-8449

  5. Arylation of trimethylvinylsilane Toluene, 20°C Jeffery, T. Tetrahedron Lett. 1999, 40, 1673-1676

  6. Iodation

  7. Results

  8. One pot synthesis Heck reaction T. Jeffery, T.; Ferber, B. Tetrahedron Lett. 2003, 44, 193-197

  9. One pot synthesis

  10. Results

  11. Conclusion

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