1 / 10

Cadherin and Fibronectin and pattern formation

Cadherin and Fibronectin and pattern formation. 江宗 諭 B9902012 李建霖 B9902018. C adherin. A class of transmembrane proteins Are dependent on Ca 2+ to function Including cadherins , protocadherins , desmogleins , desmocollins , and more. The structure of cadherin.

delila
Download Presentation

Cadherin and Fibronectin and pattern formation

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Cadherin and Fibronectin and pattern formation 江宗諭 B9902012 李建霖 B9902018

  2. Cadherin • A class of transmembrane proteins • Are dependent on Ca2+ to function • Including cadherins, protocadherins, desmogleins, desmocollins, and more.

  3. The structure of cadherin • The cadherins are synthesized as a precursor polypeptide • It contains a conserved HAV sequence

  4. Regulation of expression and signal transduction • Cadherins may be involved in invasion and metastasis of tumor cell

  5. Fibronectin • a high-molecular weight extracellular matrix glycoprotein(ch.6 p.120) • Two types are present in vertebrates： 1. soluble plasma fibronectin 2. insoluble cellular fibronectin • Plays a important role in many areas 1.生理作用 2.導致疾病 EXTRACELLULAR FLUID Fibronectin CYTOPLASM

  6. Fibronectin - structure • exists as a dimer • consists of two polypeptide chains - linked by a pair of C-terminal disulfide bonds

  7. Fibronectin - function • Fibronectin has numerous functions that ensure the normal functioning of vertebrate organisms. • Example： embryogenesis

  8. embryogenesis • 協助細胞移動(migration)、充當軌道 • inactivating the gene for fibronectin results in early embryonic lethality

More Related