1 / 16

OBAT SISTEM SARAF OTONOM

OBAT SISTEM SARAF OTONOM. Disampaikan Oleh : Ida Mukhlisa , S.Farm,Apt. Disampaikan Oleh : Ida Mukhlisa , S.Farm,Apt. Secara anatomi SSO dibagi menjadi 2 bagian besar : Parasimpatis ( Kraniosakral )

dillon
Download Presentation

OBAT SISTEM SARAF OTONOM

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. OBAT SISTEM SARAF OTONOM DisampaikanOleh : Ida Mukhlisa, S.Farm,Apt

  2. DisampaikanOleh : Ida Mukhlisa, S.Farm,Apt • Secaraanatomi SSO dibagimenjadi 2 bagianbesar : • Parasimpatis (Kraniosakral) • Secaraanatomi, serabutparasimpatisberadadikraniosakralpada spinal cord, mempunyaiserabutpreganglion yang panjangdanserabutpostganglion yang pendek. Ganglion dekatatauadapadajaringan target. • 2. Simpatis (Thorakolumbar) • Secaraanatomi, serabutsimpatisberadadibagianthorakolumbar spinal cord, memilikiserabutpreganglionpendekdengansinapsdalam ganglia yang membentukrantai – batangsimpatik. • Sebagianbesarjarignandiinervasiolehsarafparasimpatikdansimpatik, tetapiadabeberapapengecualian.

  3. Flow Chart SistemSaraf

  4. ReseptorNeurotransmitter SSO

  5. JenisReseptorOtonom

  6. Alpha Receptor

  7. AktivitasSarafOtonomterhadapBeberapaSistem Organ

  8. 1. AgonisAdrenergikKerjaLangsung Selectivitasrelatifagonisadrenoreseptor

  9. AgonisAdrenergik

  10. 3. AgonisAdrenergikKerjaCampuran Ephedrine • Alkaloid yang berasaldaritanaman, menstimulasisecaralangsungreseptor dan  sertamenstimulasipelepasannorepinephrine. • Diabsorbsisecaraoral,diekskresikandalambentuk yang tidakdiubahmelaluiurin. • Meningkatkanteanandarahmelaluistimulasi  dan . Merupakan bronchodilator. • Ephedrine menghasilkanstimulasiringanterhadap SSP  siaga  rasa lelahdanngantuk. Digunakansebagaidekongestanjuga. Toleransidantakhfilaksisdiketahuidenganbaik. Pseudoephedrine • Digunakanpadaalergi rhinitis dan flu biasa. • Padadosistinggimenyebabkan TD  danmenstimulasijantung • Diberikansecara oral. Jikadicampurdapatmenstimulasi SSP.

  11. AntagonisAdrenergik • They are subclassified on the basis of  selectivity, partial agonist activity, local anesthetic action and lipid solubility. Classification : • Non Selective  blockers: e.g. Propranolol, Satalol, PindololTimolol and Nadolol. • Cardioselective  blockers: e.g. Atenolol, Acebutolol, Metoprolol, Esmolol. • Drugs whick block both  and  adrenergic receptors e.g. Labetalol. • Non selective  blockers with vasodilator action as carvedilol. N.B :Acebutolol, atenolol and nadolol are less lipid soluble and probably enter the CNS to a lesser extent.

  12. AntagonisAdrenergik

  13. SelektivitasRelatifAntagonisuntukAdrenoreseptor

  14. ReseptorKolinergik Reseptorkolinergikterbagi 2 type : • ReseptorAChNikotinik • Reseptor Ach Muskarinik Banyakdijumpaisistemsarafdiperifermaupundipusat. Keduanyaberbedadalamhaltransduksisinyalnya.

More Related