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Roles of Protease Inhibitors for HIV-infected Children

Roles of Protease Inhibitors for HIV-infected Children. Jintanat Ananworanich. National Security Office Database. As of July 20, 2013 N of Thai children on ART = 5543 N of children on LPV/r = 1548 N of children on ATV/r = 32

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Roles of Protease Inhibitors for HIV-infected Children

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  1. Roles of Protease Inhibitors for HIV-infected Children Jintanat Ananworanich

  2. National Security Office Database • As of July 20, 2013 • N of Thai children on ART = 5543 • N of children on LPV/r = 1548 • N of children on ATV/r = 32 • Also some children on double-boosted PI (LPV/r + SQV or IDV) and on IDV/r • A few on unboosted IDV or treatment dose of RTV (not recommended) Data from Mr. ArtitPusamang and Dr. Sorakij Bhakeecheep

  3. Use of PI in Treating Pediatric HIV First-line Failure ~ 30% at 4 yrs1 N=1600 in NHSO Second-line Failure ~ 30% at 1 yr2 N=480 Third-line/salvage Failure ~ 20% at 7 mo3 N=96 1Puthanakit T, PIDJ 2007; 2Puthanakit T, AIDS Res Ther 2012; 3Ananworanich J, 2012 IAS

  4. HIVNAT 113 patient population(Failed NRTI/NNRTI/PI) HIV-NAT, Siriraj, Bamrasnaradura, Srinagarind, Nakornping, Chiang Rai, Prapokklao, Surin

  5. Data in Adults

  6. Virologic Responses of Commonly Used Third ARV for the Initial HAART Data from various clinical trials of treatment-naïve patients % of patients with VL<50 at 96 weeks except STARTMRK at 48 weeks (ITT) *EFV, ATV/r, DRV/r superiority to LPV/r ACTG5142 STARTMRK CASTLE ARTEMIS ACTG 5142, CASTLE, ARTEMIS = 96 weeks, STARTMRK=48 weeks results All combined with 2 NRTIs From the slide collection of Prof. Kiat Ruxrungtham

  7. Virologic Responses in Treatment-experienced Trials (most data at 48 wks) Wk 96 Wk 144 Active 50% 37% <33% 75% 17% OBR≥2 ETR+DRV/rRAL DRV/r MVC DRV/r DRV/r RAL+ETR+DRV/r ENF

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