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Innovative Pain Stimulator Design for Behavioral Testing

Research on endogenous pain regulatory systems and dysfunction associated with chronic pain. Our design addresses issues with existing devices for more accurate measurements. Use of drugs like Naloxone and Yohimbine for testing. LabView integration for data collection and analysis.

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Innovative Pain Stimulator Design for Behavioral Testing

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  1. Pain Stimulator Adam Platt Jen Wells Biz Slyziuk Kalee McFadden Bryan Eckerle February 16, 2004

  2. Dr. Stephen Bruehl • Research Interests • Endogenous Pain Regulatory Systems, Psychobiology of Emotions • Focus: Understanding endogenous pain regulatory systems and dysfunction associated with chronic pain. • Interaction between cardiovascular and pain regulatory systems to maintain homeostasis during painful stimuli compared to interaction in chronic pain patients

  3. Methods • Vibration • Electrical Stimulus • Thermal Stimulus • Pressure Stimulus

  4. Importance • Stimulation of C-fibers • 12m/s • Use of placebo vs. response with drugs • Measures level of activity of receptors • Draw conclusions on natural pain systems in humans

  5. Drugs to be Tested • Naloxone • Blocks opiate receptors • Used clinically for heroine overdose • Injected into patient • Yohimbine • Blocks 2 adrenergic receptors which inhibit release of norepinephrine • Used clinically for erectile dysfunction (orally) • For Dr. Bruehl’s purposes, the FDA has only approved injections

  6. Problems with Existing Device • No electronic output • Oral reading • No accurate measurement of pressure • Lever system with constant weight • No adjustability for height or hand dominance • Adjustable only for finger placement

  7. Our Design • Device • Maintain lever system • Most stable design • Reposition weight to be placed vertically above finger • Contact Point • Between top two joints on index finger of dominant hand • Middle Phalanx #2

  8. Our Design… Cont. • Table • Transportation • Positioning • Adjustable Height • Sliding Tracks • Forearm length • Slider scale mounted to table displaying “No Pain” to “Worst Pain Imaginable”

  9. Materials • Aluminum • Lucite • Steel

  10. Device Construction • In process • Featheringill machine shop

  11. Device with Measurements

  12. LabView • Timer • Sliding Scale • Digital Display • Graphical Output • Audiovisuals • Digital Data Storage • Patient • Administrator • Date • Experimental Data

  13. Schematic Slider Scale Device (Pressure Transducer) PC Computer LabVIEW A/D Converter

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