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ATM

ATM . Ataxia-telangiectasia Mutated. ATM is a member of the phosphatidylinositol 3-kinase–like protein kinases (PIKK) family of kinases. ATM and DNA damage signaling. Ataxia-telangiectasia. Brain of an Ataxia Telangiectasia Patient . Two Types of Mutations.

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ATM

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  1. ATM Ataxia-telangiectasia Mutated

  2. ATM is a member of the phosphatidylinositol 3-kinase–like protein kinases (PIKK) family of kinases

  3. ATM and DNA damage signaling

  4. Ataxia-telangiectasia

  5. Brain of an Ataxia Telangiectasia Patient

  6. Two Types of Mutations

  7. Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia Mice homozygous for the disrupted Atm allele displayed - growth retardation • neurologic dysfunction • male and female infertility secondary to the absence of mature gametes • defects in T lymphocyte maturation, and extreme sensitivity to γ-irradiation

  8. Role of the ataxia-telangiectasia gene (ATM) in breast cancer

  9. ATM is associated with a high incidence of leukemia and lymphomas

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