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Osteoporosis. Metabolic disease caused by bone demineralization ? ? bone density ? fracturesCommon areas: wrist, hip, vertebraeBone mineral desity (BMD) = T-scoresOstopenia (low bone mass) T-score between -1 and -2.5BMD decreased rapidly as estrogen levels ?Osteoporosis in post-menopausal women
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1. Management of Musculoskeletal Disorders Chapter 68 We will discuss the metabolic bone diseases (osteoporosis, osteomalacia, Paget’s Disease), Osteomyelitis, and Bone Tumors We will discuss the metabolic bone diseases (osteoporosis, osteomalacia, Paget’s Disease), Osteomyelitis, and Bone Tumors
2. Osteoporosis Metabolic disease caused by bone demineralization ? ? bone density ? fractures
Common areas: wrist, hip, vertebrae
Bone mineral desity (BMD) = T-scores
Ostopenia (low bone mass) T-score between -1 and -2.5
BMD decreased rapidly as estrogen levels ?
Osteoporosis in post-menopausal women =
T-score = -2.5
3. Osteoporosis: Classification Primary
Not associated with underlying disease
Most common in women after menopause and men in later years
Type I: postmenopausal: ages 55-65
Type II: senile: over age 65
Secondary
Related to an associated medical condition
Treatment related to underlying cause
4. Primary Osteoporosis: Risk Factors Age over 60 years
Family history
Caucasian or Asian
Thin, lean body build
Low lifetime calcium intake
Estrogen deficiency/androgen deficiency
Smoking history/high alcohol intake
Lack of physical exercise/prolonged immobility
5. Primary Osteoporosis: Clinical Manifestations Dowager’s hump, kyphosis, shortened height
Sharp, acute back pain
Tenderness, restriction of spinal movement
Vertebral compression fracture(s)
Constipation/abdominal discomfort/reflux esophagitis
Most common fractures:
Between T8 and L3
Distal end of radius and hip
6. Primary Osteoporosis: Interventions Drug therapy
Estrogen/calcium/vitamin D
Biphosphonates (BPs)
Selective estrogen receptor modulators (SERMs)
Calcitonin/androgens
Diet therapy
Prevention of falls
Exercise
Pain management
Orthotic devices
7. Osteomalacia Defect in bone mineralization resulting from lack of vitamin D
Often present with muscle weakness and bone pain
Diagnosis:
Low or normal calcium, high alkaline phosphatase
Xrays show radiolucent bands (Looser’s zones)
Treatment: increasing vitamin D intake, sun exposure and drug supplements
8. Paget’s Disease (Osteitis Deformans) Metabolic disorder of bone remodeling or turnover
Pathophysiologic phases:
Active: massive bone destruction and deformity
Mixed Bone: bone is disorganized and chaotic structure
Inactive: newly formed bone becomes sclerotic and ivory hard
Possible due to latent viral infection
Familial autosomal dominant pattern
9. Paget’s Disease: Clinical Manifestations 80% asymptomatic
Aching bone pain, worse with weight bearing
Back pain, headache, and arthritis at joint of affected bones
Nerve impingement in lumbosacral area
Loss of normal spinal curvature
Lower extremity malalignment
10. Paget’s Disease: Clinical Manifestations Bowing of long bones
Deformity of elbows and knees
Flexion contractures of hips
Enlarged, thick skull
Pathologic fractures
Skin changes: flushed, warm
Apathy, lethargy, fatigue
Other: Hyperparathyroidism and gout, urinary or renal stones, heart failure
11. Paget’s Disease: Interventions Nonsurgical
Relieve pain
Decrease bone resorption
Surgical
Partial or total joint replacement
12. Osteomyelitis Infection of the bone
Acute
Most common in children
Infection moves from another part of the body to the bone tissue
Penetrating trauma
Chronic
Results from acute type
Common in adult with compromised vascular supply
Advance age and concurrent disease
13. Osteomyelitis: Assessment Fever
Swelling and tenderness at affected site
Erythema and heat
Draining ulcers
Bone pain
Elevated WBC, ESR
50% have positive blood cultures
14. Osteomyelitis: Interventions Nonsurgical
Drug therapy
Infection control
Hyperbaric oxygen therapy
Surgical
Sequestrectomy
Bone grafts
Bone segment transfers
Muscle flaps
Amputation
15. Bone Tumors Major classifications
Chonrogenic: arise from cartilage
Osteogenic: arise from bone
Fibrogenic: arise from fibrous tissue
16. Benign Bone Tumors Most often asymptomatic
Symptoms may include: pain, tenderness and/or swelling at site
Diagnostics: xray, CT, bone biopsy
Nonsurgical Management:
Pain medication
Heat and/or cold applications
Surgical Management:
Curettage
Excision with bone/joint restoration
17. Malignant Bone Tumors May be primary or secondary
Clinical manifestations: non-specific c/o (pain, local swelling, and tender, palpable mass)
Cause psychosocial issues
Lab: ? serum alkaline phosphatase (ALP)
Dx: xrays, CT, Bone bx, Bone scan
Nonsurgical
Drug therapy
Radiation
Surgical
Wide or radical resection
Limb salvaging procedures