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MGSD Studies

This cross-sectional, multicentre, and multinational study aims to detect cases of atypical non-autoimmune diabetes in the Mediterranean region through genetic analysis of saliva samples. The objective is to provide diabetes specialists with an innovative tool for diagnosing new cases of atypical diabetes and improving patient care.

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MGSD Studies

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  1. MGSD Studies • Geneticdiagnosis of atypical non-automimmunediabetes:M. Marre (France)

  2. Genetic diagnosis of atypical non-autoimmune diabetes in the Mediterranean area Prof. Michel Marre

  3. Monogenic diabetes study in the Mediterranean region • Cross-sectional, multicentre and multinational study covering the Mediterranean region to detect monogenic diabetes among patients suspected to be with atypical diabetes • Objective: to provide diabetes specialists with an innovative tool to diagnose new cases of atypical non-autoimmune diabetes among their patients in order to improve patient care • Methodology: genetic analysis of saliva sample with a PCR-based enrichment technology in combination with massively parallel sequencing at a unique visit

  4. Inclusion / exclusion criteria • Inclusion criteria • Patients suspected of having atypical diabetes and followed for the disease in the different study centers • Adults and underage children • Selection procedure will rely on the investigator assessment, helped by the use of the MODY risk calculator (>25%) • Exclusion criteria • Secondary diabetes due to pancreatic disease, diabetogenic drug, endocrine disease • Type 1 diabetes as established by the investigator.

  5. Genetic analysis • Performed by the European Genomic Institute for Diabetes (EGID) • Technique: genetic analysis of saliva sample with a PCR-based enrichment technology in combination with massively parallel sequencing at a unique visit • Results will be analyzed by EGID to establish the diagnosis of monogenic diabetes

  6. France Serbia Turkey Greece Cyprus Malta Lebanon Morocco Tunisia Algeria

  7. 10 Participating countries, 45 centers 250 patients

  8. Update on the inclusions France Serbia Turkey Greece Cyprus Malta Lebanon Morocco Tunisia Algeria

  9. Timeline Medical writing Statistic analysis Results mailing Genetic analysis Inclusion Material shipment End of analysis + results End of inclusion Study data May 2018 Oct 2017 Mar 2018 Feb 2017 Apr 2017

  10. Thank you

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