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Influenza Vaccine Responses

Influenza Vaccine Responses. Zhiping Ye, M.D., Ph.D. Division of Viral Products. Prepared for Vaccines and Related Biological Products Advisory Committee 21 February 2008. Serum panels used for serology. AUSTRALIA, IAN BARR, PH.D. ADULTS A/NEW CALEDONIA/20/99 IVR-116 (H1N1)

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Influenza Vaccine Responses

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  1. Influenza Vaccine Responses Zhiping Ye, M.D., Ph.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee 21 February 2008

  2. Serum panels used for serology AUSTRALIA, IAN BARR, PH.D. ADULTS A/NEW CALEDONIA/20/99 IVR-116 (H1N1) WHO, AUSTRALIA ELDERLY A/WISCONSIN/67/2005 X161B (H3N2) B/MALAYSIA/2506/2005 EUROPE, JOHN WOOD, PH.D. ADULTS A/SOLOMON ISLANDS/03/2006 IVR-145 (H1N1) NIBSC, ENGLAND ELDERLY A/WISCONSIN/67/2005 X161B (H3N2) B/MALAYSIA/2506/2005 JAPAN, TAKATO ODAGARI, PH.D. ADULTS A/SOLOMON ISLANDS/03/2006 IVR-145 (H1N1) NIID, JAPAN ELDERLY A/HIROSHIMA/52/2006 IVR-142 (H3N2) B/MALAYSIA/2506/2005 USA, STEFAN GRAVENSTEIN, M.D. ADULTS A/SOLOMON ISLANDS/03/2006 IVR-145 (H1N1) EASTERN VIRGINIA ELDERLY A/WISCONSIN/67/2005 X161B (H3N2) MEDICAL SCHOOL PAEDIATRIC B/MALAYSIA/2506/2005 1

  3. Antigens for serology (H1N1) VACCINE STRAIN A/Solomon Islands/03/2006 IVR-145 REPRESENTATIVE CURRENT STRAINS • A/Brisbane/59/2007 • A/Egypt/10/2007 • A/Hiroshima/93/2007 • A/Netherlands/345/2007 • A/Norway/1747/2007 • A/Paris/0641/2007 • A/South Dakota/6/2007 • A/Cambodia/0371/2007 • A/Brisbane/3/2006 2

  4. HI ANTIBODY RESPONSES TO THE H1N1 ADULT POPULATION (CBER) 3

  5. HI ANTIBODY RESPONSES TO THE H1N1 ELDERLY POPULATION (CBER) 4

  6. HI ANTIBODY RESPONSES TO THE H1N1 PEDIATRIC POPULATION (CDC-CBER) 5

  7. A/Solomon Islands/3/2006 vaccineSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ADULT) 6

  8. A/Solomon Islands/3/2006 vaccineSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ELDERLY) 7

  9. Antigens for serology (H3N2) VACCINE STRAINS A/Wisconsin/67/2005 X161B A/Hiroshima/52/2006 IVR-142 REPRESENTATIVE CURRENT STRAINS • A/Brisbane/10/2007 • A/Henan Jinshui/147/2007 • A/Taiwan/760/2007 • A/Texas/37/2007 • A/Toyama/119/2007 • A/Uruguay/716/2007 8

  10. HI ANTIBODY RESPONSES TO THE H3N2ADULT POPULATION (UK) 9

  11. HI ANTIBODY RESPONSES TO THE H3N2ELDERLY POPULATION (UK) 10

  12. HI ANTIBODY RESPONSES TO THE H3N2 PEDIATRIC POPULATION (CDC-CBER) 11

  13. A/Wisconsin/67/2005-like VACCINESSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ADULT) 12

  14. A/Wisconsin/67/2005-like VACCINESSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ELDERLY) 13

  15. Antigens for serology (B) VACCINE STRAIN B/Malaysia/2506/2004 (Vic) REPRESENTATIVE CURRENT STRAINS • B/Hiroshima/320/2007 (Vic) • B/Pennsylvania/5/2007 (Vic) • B/Bangladesh/3333/2007 • B/Delaware/1/2007 • B/Florida/4/2007 • B/Norway/1760/2007 • B/Sendai-H/114/2007 14

  16. HI ANTIBODY RESPONSES TO BADULT POPULATION (CDC) 15

  17. HI ANTIBODY RESPONSES TO BELDERLY POPULATION (CDC) 16

  18. HI ANTIBODY RESPONSES TO B PEDIATRIC POPULATION (CDC-CBER) 17

  19. B/Malaysia/2560/2004 VACCINESSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ADULT) 18

  20. B/Malaysia/2560/2004 VACCINESSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ELDERLY) 19

  21. Serologic conclusions Studies with human sera collected after immunization with current vaccines show that: • H1N1 • Representative recent viruses were less well inhibited by HA antibodies to current vaccine strains (A/Solomon Islands/3/2006-like virus). • H3N2 • Representative recent viruses were less well inhibited by HA antibodies to current vaccine strain (A/Wisconsin/67/2005-like virus). • B • B/VICTORIA/2/87-lineage • Representative recent viruses were well inhibited by HA antibodies to current vaccine strain (B/Malaysia/2506/2004-like virus). • B/YAMAGATA/16/88-lineage • Representative recent viruses generally were less well inhibited by HA antibodies to the current vaccine strain. 20

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