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INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part IV Adrenergic and cholinergic receptors

INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part IV Adrenergic and cholinergic receptors. Adrenergic Receptors: Receptors Activated by EPI/NE.  -adrenergic receptors (Epinephrine>Isoproterenol).  -adrenergic receptors (Isoproterenol>Epinephrine). a.  1 -adrenergic receptors (EPI = NE).

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INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part IV Adrenergic and cholinergic receptors

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  1. INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part IV Adrenergic and cholinergic receptors

  2. Adrenergic Receptors: Receptors Activated by EPI/NE -adrenergic receptors (Epinephrine>Isoproterenol) -adrenergic receptors (Isoproterenol>Epinephrine) a  1-adrenergic receptors (EPI = NE) 1-adrenergic receptors (Phenylephrine>Clonidine)  2-adrenergic receptors (EPI>NE) 2-adrenergic receptors (Clonidine>Phenylephrine)  3-adrenergic receptors (NE>EPI)

  3. Adrenergic Receptors: Signal Transduction

  4. Signal Transduction by 1 - Adrenergic Receptors Gq q q

  5. Signal Transduction by 2 - and  - Adrenergic Receptors

  6. Cholinergic Receptors: Receptors Activated by Ach Muscarinic Receptors (Activated by muscarine from Amanita muscaria) Nicotinic Receptors (Activated by nicotine from tobacco) M1 (Nerve Cells) (Defined by Molecular Cloning) M2 (Heart & SM) NM (Neuromuscular) M3 (Heart & SM) (Blocked by Tubocurarine) NN Autonomic ganglia, Adrenal medulla & CNS M4 (SM & Glands) M5 (?) (Blocked by Trimethaphan)

  7. Cholinergic Receptors: Signal Transduction

  8. Muscarinic Receptors Gq Activation of PLC Gi Formation of IP3 Formation of DAG  subunit  subunit Release of Intracellular Calcium Activation of PKC Inhibition of Adenylyl Cyclase Opening of Potassium Channels

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