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Global View of ESRD Patients

Growth Rates. World population 1. 2 % ESRD ~ 7 % Haemodialysis 7-8 % Peritoneal Dialysis ~ 7 % Transplants ~ 6 % . ESRD Patients 2,310, 0 00 thereof Dialysis 1,775,000 (77%) HD 1, 585 , 0 00 (69%) PD 190, 0 00 (8%)

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Global View of ESRD Patients

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  1. Growth Rates World population 1.2% ESRD ~ 7% Haemodialysis 7-8% Peritoneal Dialysis ~ 7% Transplants ~ 6% ESRD Patients 2,310,000 • thereof Dialysis 1,775,000 (77%) HD 1,585,000 (69%) PD 190,000 (8%) • thereof Transplants 535,000 (23%) Global View of ESRD Patients World population: 6.7 billion Global Prevalence Patients per million population (p.m.p.) Global Prevalence Development Dialysis patients per million population (p.m.p.)

  2. USA 3 - 4 % EU 3 - 4 % Japan 2 - 3 % Other 11-13 % Total ~ 7 % Global View of Dialysis Patients Growth Rates 2007-2008 1,775,000 Dialysis Patients USA 21% Other 46% EU 17% Japan 16% Patient Numbers thousands HD - PD Split 49% 46% HD 89% 34% 15% PD 11% 16% 20% 16% 17% 21% 20% 21% 25% estimation Source: FME Market and Competitor Survey, 2008

  3. USA 305 5% 371 21% 1,215 Japan 127 2% 287 16% 2,250 China 1,334 20% 94 5% 70 Brazil 198 3% 88 5% 450 Germany 82 1% 76 4% 925 Countries 6 - 15 1,717 25% 407 23% 235 Countries 16 - 146 2,792 41% 452 26% 160 Countries 147 - 232 185 3% 0 0% 0 Relative Population Profiles Dialysis % of total Dialysis prevalence (p.m.p.) Population % of world patients dialysis (millions) population (thousands) patients Country Global 6,740 1,775 265

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