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HUMAN DISEASE

HUMAN DISEASE. http://www.ncbi.nlm.nih.gov/pubmedhealth/s/diseases_and_conditions/a/. MEDICAL BIOTECHNOLOGY. Seeks to Understand human health and disease Use biotechnologies to prevent, diagnose, treat/cure disease and its recurrence. HUMAN DISEASE. Acute Structural such as gallstones

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HUMAN DISEASE

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  1. HUMAN DISEASE http://www.ncbi.nlm.nih.gov/pubmedhealth/s/diseases_and_conditions/a/

  2. MEDICAL BIOTECHNOLOGY • Seeks to • Understand human health and disease • Use biotechnologies to prevent, diagnose, treat/cure disease and its recurrence

  3. HUMAN DISEASE • Acute • Structural such as gallstones • Infectious such as pneumonia • Chronic • stable (stays the same) • Progressive, gets worse and sometimes negatively affects other areas of the body • Some do both in different people

  4. HUMAN DISEASE • Genetic – Down’s syndrome • Behavioral – smoking causes lung cancer

  5. HUMAN DISEASE: Classified by impacted organ, tissue or cellular system • Cardiovascular • Pulmonary • Renal • Gastrointestinal • Liver and biliary system • Hematologic • Metabolic • Endocrine

  6. HUMAN DISEASE: Classified by impacted organ, tissue or cellular system • Women’s and Men’s health • oncologic • Bone and bone mineral metabolism • Musculoskeletal and connective tissue • Neurologic • Infectious • Aging • Substance abuse

  7. http://www.ivy-rose.co.uk/Revise/AnatomyPhysiology/index.php http://www.nccpa.net/ExamsContentBPOrgans.aspx

  8. CASE STUDY HEPATITIS C VIRUS • Infection of the liver leading to inflammation • Some(15%) people recover from infection; most become chronic carriers • Most infections are asymptomatic for about 20 years • Complicated disease process that progresses but not in all patients • Immune response and genome (HLA) impact outcome • Liver cancer • Liver failure NORMAL FIBROTIC CIRRHOTIC

  9. CASE STUDY – DOWN SYNDROME • Genetic defect – 3 copies of chromosome 21 occurs early in embryo development; = error in cell division • Identified prenatally • Causes problems with the way the body and brain develop • Most common chromosomal defect

  10. CASE STUDY – DOWN SYNDROME • Mild to severe in terms of physical appearance as well as mental and social development • low muscle tone, small stature, an upward slant to the eyes, and a single deep crease across the center of the palm

  11. CASE STUDY - BEHAVIORAL • Lung cancer because of smoking • Liver disease because of alcohol abuse

  12. CASE STUDY – MYASTHENIA GRAVIS • Acquired autoimmune disorder that lessens transmission across neuromuscular junctions weakening muscle responses • Autoantibodies to acetylcholine receptor (AChR )block binding of Ach • Weakens voluntary skeletal or ocular muscles • Loss of facial expression, muscle fatigue, droopy eyelids • Female to male ration = 6:4

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