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Lycopene

Lycopene. Group 13. 茄紅素. Clinical trials. Lycopene In Preventing of Prostate Cancer Condition: Prostate Cancer Lycopene in Treating Patients With Metastatic Prostate Cancer Conditions: stage IV prostate cancer; recurrent prostate cancer

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Lycopene

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  1. Lycopene Group 13

  2. 茄紅素

  3. Clinical trials • Lycopene In Preventing of Prostate CancerCondition: Prostate Cancer • Lycopene in Treating Patients With Metastatic Prostate CancerConditions: stage IV prostate cancer; recurrent prostate cancer • Lycopene in Preventing Prostate Cancer in Healthy ParticipantsCondition: Prostate Cancer • Isoflavones Compared With Lycopene Before Surgery in Treating Patients With Stage I or Stage II Prostate CancerConditions: stage I prostate cancer; stage II prostate cancer

  4. Lycopene • Acyclic carotenoid (A family of natural pigments found in plants and animals) • A powerful (?) antioxidant (Böhm et al 2002) • Prevention of cardiovascular disease and cancer (Kohlmeier et al. 1997; Giovannucci 1999)

  5. Metabolism • Higher bioavailability of lycopene in heated or processed food. (Agarwal and Rao 1998; Porrini and Riso 2000) • Lipids in the diet increase the absorption of lycopene

  6. Biosynthetic pathway Glucose Acetyl-CoA Pyruvate + G3P 1-deoxy-D-xylulose 5-phosphate (DXP) Mevalonate Isopentenyl diphosphate (IPP) Dimethyallyl-PP (DMAPP) GPP FPP GGPP Lycopene

  7. D-1-deoxyxylulose 5-phosphate synthase (DXS)

  8. Hydroxymethylglutaryl-CoA synthase

  9. Farnesyltranstransferase. (Geranylgeranyl-diphosphate synthase )

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