1 / 15

The Damage and Repair of DNA

The Damage and Repair of DNA. Two main types of DNA damage: *point mutations *structural changes. The molecular basis of point mutations. 1. Base substitution (mismatches) transition transversion. 2. Tautomeric shift. Gene Mutation. The molecular basis of point mutations.

ginny
Download Presentation

The Damage and Repair of DNA

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Damage and Repair of DNA Two main types of DNA damage: *point mutations *structural changes The molecular basis of point mutations 1. Base substitution (mismatches) transition transversion 2. Tautomeric shift

  2. Gene Mutation The molecular basis of point mutations 3. Base analogs and chemical mutagens

  3. DNA Damage The molecular basis of structural damage 1. Hydrolytic damage Deamination N-glycosidic bond – very weak and easily broken Depurination Deamination

  4. DNA Damage The molecular basis of structural damage 2. Alkylation

  5. DNA Damage The molecular basis of structural damage 3. Oxidation and Radiation

  6. Repairing Damages Bases 1. Mismatch repair (MMR) Dam methylase: MutS:

  7. Repairing Damages Bases 1. Mismatch repair (MMR)

  8. Repairing Damages Bases 2. Photoreactivation

  9. Repairing Damages Bases 3. Repair of alkylation

  10. (BER) Repairing Damages Bases 4. Base excision repair (BER)

  11. Repairing Damages Bases 4. Base excision repair (BER)

  12. Repairing Damages Bases 5. Nucleotide excision repair (NER)

  13. DNA Repair 7. Double Strand Break Repair (DSB) Nonhomologous End-Joining (NHEJ) Ku XRCC4 DNA-PKcs Artemis Ligase

  14. DNA Repair 8. Double Strand Break (DSB) repair (Homologous Recombination)

  15. DNA Repair 8. Double Strand Break (DSB) repair (Homologous Recombination)

More Related