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GONADAL HORMONES for 3 rd Year Medicine

GONADAL HORMONES for 3 rd Year Medicine. Testicular Steroidogenesis and its Endocrine Control. Lectures 1 & 2. Learning objectives. By the end of this lecture, the student will be able to: Identify the type of hormones involved in testicular steroidogenesis and their origin.

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GONADAL HORMONES for 3 rd Year Medicine

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  1. GONADAL HORMONESfor 3rd Year Medicine

  2. Testicular Steroidogenesis and its Endocrine Control Lectures 1 & 2

  3. Learning objectives By the end of this lecture, the student will be able to: • Identify the type of hormones involved in testicular steroidogenesis and their origin. • Illustrate the pathway of formation of male sex hormones and factors controlling them. • Discuss mode of action of hormones. • Explain the pathological consequences due to biosynthetic defects.

  4. Content Testosterone and androgens: • Origin. • Biosynthesis. • Mode of transport. • Mode of action. • Control of steroidogenesis.

  5. Female Sex Hormones Lectures 3 & 4

  6. Learning objectives • By the end of this lecture, the student will be able to: 1-Define female sex hormones and their origin. 2- Describe the pathway of formation of female sex hormones and factors controlling it. 3- Relate the pathological consequences to biosynthetic and transport defects. 4- Demonstrate how to assess gonadal function.

  7. Content • Oestradiol and progesterone: • Origin. • Biosynthesis. • Mode of transport. • Mode of action. • Control of steroidogenesis. • Assessemnt of femal sex hormones disorders.

  8. Biochemical Investigations of Infertility Lecture 5

  9. Learning objectives By the end of this lecture, the student will be able to: 1-Identify a scheme of investigations in male and female. 2- Interpret the outcome of investigations for further decision.

  10. Content • Types of abnormalities in male and female. • Endocrine causes of sub-fertilities in female. • Endocrine investigations in the sub-fertile man. • FSH, LH, testosterone, prolactin, progesterone

  11. Prenatal Diagnosis Lecture 6

  12. Learning objectives By the end of this lecture, the student will be able to: 1- Explain maternal and fetal screening. 2- Discuss the genetic analysis of DNA. 3- Identify types of disease that can be screened by prenatal diagnosis. 4- Identify the metabolic changes found in the maternal blood indicating inherited metabolic defects.

  13. Content • Fetal DNA analysis in maternal circulation in the detection of genetic diseases. • The value of biochemical information in prenatal diagnosis: • AFP • UE • BHCH (Urine / Semen) • Inhibin • Calculation of risk for Down’s syndrome. • Investigation of Neural tube defects. • Abnormal metabolic changes in maternal / fetal sampling in relation to inherited genetic disorders.

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