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Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Present

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Presentation By: Christina Stujenske.

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Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Present

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  1. Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene.Presentation By: Christina Stujenske Dean et.al. Sept 27 1996. Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene.. Science 273:1858-1862

  2. Genetic frequency and HIV-1 High Risk Patients • Once CCR5 was identified as a co-receptor for HIV, researchers wanted to investigate if the genes for CCR5 affected resistance to HIV in cohorts • High risk patients were divided into infected and noninfected groups and a number of loci were examined to determine genetic frequencies.

  3. Genetic Frequency and Loci • 170 loci were selected based on polymorphisms, involvement in retroviral infection (pathogenesis), and genetic location. • Test group: HIV-1-infected versus HIV-1-antibody-negative individuals • Only 1 of the loci, CCR5, displayed significant difference in distortion of genotype frequencies among test group. • Highly significant departure from genotype equilibrium in Caucasian homosexual men.

  4. A Distortion in CCR5 • Only CCR5 displayed significant difference in distortion of genotype frequencies among test group. • Because defect was found in only CCR5, expression of the defect may account for differences in susceptibility to HIV.

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