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Beyond Mendel

Beyond Mendel. Into the Genetic Frontier. Mendel is the tip of the “genetics iceberg”. Mendelian Genetics. As people have studied genetics, they have realized that the inheritance of traits is much more complex than Mendel’s work with peas indicated. Mendelian Genetics The Rest of Genetics.

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Beyond Mendel

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  1. Beyond Mendel Into the Genetic Frontier

  2. Mendel is the tip of the “genetics iceberg” Mendelian Genetics As people have studied genetics, they have realized that the inheritance of traits is much more complex than Mendel’s work with peas indicated. Mendelian Genetics The Rest of Genetics

  3. Polygenic traits • Some traits which have many possible phenotypes are controlled by more than one gene. - the interactions of these genes allows for the large numbers of phenotypes. - human examples: Hair, eye and skin color

  4. The Inheritance of Eye Color • Only partially understood. • at least 3 different genes with 2 alleles each are responsible for eye color. – bey 1 bey 2 and gey • These genes code for the formation of the pigment melanin • The function of only 2 of the 3 genes is currently understood

  5. The Inheritance of Eye Color as it is Currently Understood • Known as the 2 gene model • One gene known as bey 2 has 2 alleles B for brown eyes and b for blue eyes • The other gene known as geyhas 2 alleles G codes for green eyes and g for blue eyes

  6. The 2 Gene Model - B is dominant to all other alleles- BBGG,BBGg,BBgg,BbGG BbGg,Bbgg=Browneyes - G is dominant to b bbGG, bbGg= Green eyes - bbggonly = blue eyes

  7. Pleiotropy-one gene multiple traits • When a single gene influences multiple traits this is known as Pleiotropy example: Marfan’s Syndrome - a dominant disorder caused by a single gene - the defective gene causes individuals to be tall and skinny with very long fingers, hyper joint mobility, eye and heart defects

  8. More Pleiotropy-Marfans Pleiotropy is thought to occur when a gene codes for a protein that is involved in a several processes

  9. Epistasis • The action of one gene influencing the expression of another. -Example: In mice the color is controlled by one gene with 2 alleles - the allele for gray (G) is dominant to the allele for black (g) - Another gene controls an early stage in the development of hair pigment - normal color development (A) is dominant to no color development(a) - AA, Aa = color production - aa = no color production = albino mouse

  10. Epistasis in mice • The gene for color production influences the expression of the gene for fur color

  11. More Epistasis – Bombay Phenotype • influences the expression of A and B blood types - the gene involved is responsible for the formation of antigens on blood cells. The dominant form of the gene allows the formation of antigens HH or Hh allow antigens to form The recessive form prevents the formation of antigens hh means no antigens form

  12. -If an individual is HH or Hhfor blood antigen formation then: AA, AO = A blood BB, BO = B blood AB = AB blood -If an individual is hh for blood antigen formation then: AA, AO = O blood BB, BO = O blood AB = O blood

  13. Environment Can Influence Gene Expression example: Siamese cats - Siamese coloring is a partial albinism. Most of the cat is white -Black fur is only expressed in areas where the temperature is lower than the rest of the body - if black hair is shaved and the area kept warm then the hair that grows back will be white - if white hair is shaved and the area is cooled, then the hair will grow back black

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