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Chapter Sixteen

Chapter Sixteen. HIV and AIDS. HIV/AIDS. Human Immunodeficiency Virus (HIV) Immune system deficient, cannot resist disease Virus responsible for Acquired Immune Deficiency Syndrome (AIDS) Acquired Immune Deficiency Syndrome (AIDS) Descriptive of the infection and it’s progression

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Chapter Sixteen

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  1. Chapter Sixteen HIV and AIDS

  2. HIV/AIDS • Human Immunodeficiency Virus (HIV) • Immune system deficient, cannot resist disease • Virus responsible for Acquired Immune Deficiency Syndrome (AIDS) • Acquired Immune Deficiency Syndrome (AIDS) • Descriptive of the infection and it’s progression • First observed in U.S. cities in early 1980s • Young, healthy men dying of rare diseases

  3. Conditions Associated with AIDS • Opportunistic infections • Pneumocystis carinii pneumonia (PCP) • Mycobacterium avium intracellulare • Clinical conditions • Wasting syndrome • Cancers • Kaposi’s sarcoma • Other infections • Candidiasis • Herpes and cytomegalovirus

  4. Unexplained persistent fatigue Fever, chills, night sweats Unexplained weight loss Swollen lymph nodes Pink, red, purple, or brown blotches Persistent dry cough Persistent, fuzzy, white spots in mouth, tongue, or throat Memory loss or depression Abnormal pap smears Persistent vaginal candidiasis Abdominal cramping (due to Pelvic inflammatory Disease) Persistent Diarrhea Symptoms of HIV Infection and AIDS

  5. The Immune System and HIV • Leukocytes – white blood cells • Macrophages • Engulf foreign particles • Antigens • Stimulate immune system, react with antibodies • Antibodies • Inactivate antigens, mark them for destruction • B cells and T cells • Lymphocytes • Helper T cells

  6. The Virus • Protein coated package of genes • Spherical • GP 120 • Reverse transcriptase • Retrovirus • Effect on T cells

  7. How the Disease Progresses • T cell (CD4) count • Viral load counts • Phases of infection • Months to years • Early flu-like symptoms • AIDS • Death

  8. Epidemiology and Transmission of HIV • Epidemiology – Study of incidence, process, distribution, and control of a disease • World Health Organization reports 25 million people have died from AIDS • Estimated that 40.3 million people are living with HIV

  9. Epidemiology and Transmission of HIV • Global increases in number of people living with AIDS • African continent the largest concentration • 2/3 of all AIDS cases are in Sub-Saharan Africa • 77% of women living with AIDS are in Sub-Saharan Africa

  10. Epidemiology and Transmission of HIV in the United States • 944, 306 individuals living with AIDS • 40,000 annual new HIV infections • Changes in current transmission modes • Changes across ethnic groups

  11. Modes of Transmission • Sexual contact • Sharing needles • Transfusions • Passing virus from mother to fetus

  12. Modes of Transmission • Breastfeeding from HIV-positive mother • Sharing sex toys • Accidental contamination with infected blood • Contaminated blood transfusions or organ transplants performed before April 1, 1985

  13. Myths about Transmission • Non sexual contact – touching a person • Touching a surface – toilet seat • Social contact – kissing, biting or tears • Insect bites • Accidental contact in sports • Donating blood

  14. Sexual Transmission • Anal intercourse • Vaginal intercourse • Oral sex • Sex toys

  15. Injection Drug and Substance Use • Sharing needles • Sharing other paraphernalia • Recreational use resulting in poor decision making

  16. Mother to Child Transmission • Peri natal transmission • Greatly reduced by use of ZDV (AZT) • Mother takes ZDV from week 14 to 34 • Infant takes ZDV

  17. Minority Races and Ethnicities and HIV • In the early 80s, was viewed as a disease in Whites and gays • Currently identified in all ethnic groups • Occurs in groups with • Poverty • Lack of access to or willingness to use health care • Substance abuse

  18. Minority Races and Ethnicities and HIV • African Americans • Hispanics • Asian/Pacific Islanders • American Indians and Alaska Natives

  19. The Gay Community • Men who have sex with men • Stigma slowed prevention efforts • Special consideration of ethnic groups • Psychological long term effects • Increased risk taking • Other STIs • U.S. AIDS Demographics by Race

  20. Other Groups and HIV • Children • Teens and college students • Older adults • Geographic region

  21. Prevention and Treatment • Protecting ourselves • Be aware that alcohol and drug use increases risky behaviors • Develop communication skills to be able to discuss risks and prevention with partners • Use HIV testing and make appropriate decisions • Use condoms

  22. Prevention and Treatment • Saving lives through prevention • Reduced new infections from 150,000/year to 40,000/year • Obstacles to education: blame and denial • AIDS seen as disease of marginalized group, not “us” • Needle exchange programs • HIV testing

  23. HIV Testing • Tests should be taken 12 weeks after high-risk behavior, repeated 6 months after an uncertain result • Types of tests • ELISA - enzyme-linked immunosorbent assay • Western blot –rechecks ELISA results • Viral load tests measure HIV in bloodstream • Getting tested • Partner notification

  24. Treatment • Usually initiated with the diagnosis of AIDS • Antiretroviral medications • Nonnucleoside reverse transcriptase inhibitors • Nucleoside reverse transcriptase inhibitors • Protease inhibitors • Fusion Inhibitor • HAART – Highly Active Antiretroviral Therapy • Combination of three or more medications • Reduces HIV in blood to undetectable levels

  25. Living with HIV or AIDS • If you are HIV positive • Taking care of your health • Addressing your other needs • If you are caring for someone with HIV or AIDS

  26. Summary • What is AIDS? • The epidemiology and Transmission of HIV • AIDS demographics • Prevention and Treatment • Living with HIV or AIDS

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