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Hoogtepunten APA 22 mei 2008 Stemmingsstoornissen

22/05/2008. Hans van den Ameele - hoogtepunten APA . 2. Highlights APA - 22 mei 2008 Stemmingsstoornissen. vraagstelling: controverse antidepressiva ? selectie presentaties algemene indruk highlights ?. 22/05/2008. Hans van den Ameele - hoogtepunten APA . 3. Highlights APA - 22 mei 2008 Stemmin

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Hoogtepunten APA 22 mei 2008 Stemmingsstoornissen

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    1. 22/05/2008 Hans van den Ameele - hoogtepunten APA 1 Hoogtepunten APA 22 mei 2008 Stemmingsstoornissen Hans van den Ameele

    2. 22/05/2008 Hans van den Ameele - hoogtepunten APA 2 Highlights APA - 22 mei 2008 Stemmingsstoornissen vraagstelling: controverse antidepressiva ? selectie presentaties algemene indruk highlights ?

    3. 22/05/2008 Hans van den Ameele - hoogtepunten APA 3 Highlights APA - 22 mei 2008 Stemmingsstoornissen Psychiatric issues in women through the adult life-cycle (industry supported symposium Wyeth) An interactive symposium: unlocking the combination moving toward a better understanding of major depressive disorder (Wyeth) Novel and current antidepressants: state of the art management of depression (Novartis) Focus live: major depressive disorder Research advances in psychiatry: mood disorders (Helen Mayberg) Depression and generalized anxiety: research planning for the DSM-V (symposium)

    4. 22/05/2008 Hans van den Ameele - hoogtepunten APA 4 Highlights APA - 22 mei 2008 Stemmingsstoornissen Cellular plasticity cascades: a window into mood disorders (lecture, Husseini Manji) Research advances: Brain mechanisms of bipolar disorder and major depression (symposium) Tales of music and the brain (lecture, Oliver Sacks) Prozac and the Spiritual Self (lecture, Dan Blazer) Diagnosis - validity (scientific and clinical report session) Primary care depression management (issue workshop) New research poster session: anxiety and mood disorders

    5. 22/05/2008 Hans van den Ameele - hoogtepunten APA 5 Depression and generalized anxiety: research planning for the DSM-V diagnostische/nosologische relatie GAD-MDD ? ? vormen van één ziekte of ? ziekte empirische data ? nosologie ? ‘validators’ ? cultuur, genetica, neurobiologie, verloop, behandeling,… DSM: descriptief ? etiologisch ? essentialisme vs nominalisme categoriaal vs continuüm ‘test-case’ Validators: externe correlaten van zikete, niet betrokken bij procesValidators: externe correlaten van zikete, niet betrokken bij proces

    6. 22/05/2008 Hans van den Ameele - hoogtepunten APA 6 Depression and generalized anxiety: research planning for the DSM-V cultuur (Stein) ‘culture bound disorders’ ? ‘disease’ vs ‘illnes’ GAD ? MDD genetica (Kendler) familie en 2-ling studies: omgeving bepaalt verschil GAD en MDD: verschillende vorm van zelfde aandoening neurobiologie (Nemeroff) GAD ? MDD: specifieke neuro-anatomische en functionele stoornissen Validators: externe correlaten van zikete, niet betrokken bij procesValidators: externe correlaten van zikete, niet betrokken bij proces

    7. 22/05/2008 Hans van den Ameele - hoogtepunten APA 7 Depression and generalized anxiety: research planning for the DSM-V verloop (Kessler) National Comorbidity survey: lifetime prev. MDD: 28.8% - GAD: 11.9% ? ‘onset risk reciprocity’ - risico factoren – persistentie – stabiliteit GAD en MDD: ? maar verwante aandoeningen behandeling (Kupfer) pooled effect size van studies: ‘shared treatment response’ ? GAD: subtype MDD goede validator ? betere diagnostische dissectie ? conclusie ? different but "closely-related" Validators: externe correlaten van zikete, niet betrokken bij procesValidators: externe correlaten van zikete, niet betrokken bij proces

    8. 22/05/2008 Hans van den Ameele - hoogtepunten APA 8 Cellular plasticity cascades: a window into mood disorders (Husseini Manji) neurobiologie van ernstige stemmingsstoornissen niet: ‘imbalance in neurotransmitters in the brain’, maar: ‘disorder of synapses and circuits’ - ‘impairments of synaptic and neural plasticity - in cellular plasticity cascades' nieuwe R/: ‘therapy inside the cell’ – ‘endophenotype strategy’ targeting cellular resilience molecules optimale R/ bij therapie resistentie: neurotrofisch en neurochemisch ‘restore circuitry so neurotransmitters can do their job’

    9. 22/05/2008 Hans van den Ameele - hoogtepunten APA 9 Cellular plasticity cascades: a window into mood disorders huidige AD: delay adaptatie in intracellulaire (neurotrofische) cascades indirect effect op synaptische en neuronale plasticiteit via NMDA en AMPA receptoren (glutamaat) stemmingsstabilisatoren Li en valproaat: neuroprotectieve en neurotrofische effecten NMDA, glutamaat, PKC, GSK-3, IMPAse, Bcl-2, … neurogenese: MRI studies neurobiologie ? genetisch onderzoek turn on/off genes (BAG-1 FKBP5) neurotrofische molecules als targets: BDNF, Bcl-2,… ? nieuwe R/: directe invloed op NMDA/AMPA receptoren, PKC, Bcl-2,….

    10. 22/05/2008 Hans van den Ameele - hoogtepunten APA 10 Cellular plasticity cascades: a window into mood disorders PKC-inhibitoren (Proteine Kinase C) Li, valproaat, tamoxifen, bryostatin-I, ruboxistaurin tamoxifen: significante verbetering manie vanaf 5e dag NMDA receptor antagonist ketamine ketamine iv bij ernstige depressieve Pt: na 24 uur: 70% responders (HDRS) glutamaat inhibitie, AMPA ? riluzole Bcl-2 - neurotrophic/neuroprotective protein lithium (? bcl-2) – valproaat ? rol in AD respons ?

    11. 22/05/2008 Hans van den Ameele - hoogtepunten APA 11 Cellular plasticity cascades: a window into mood disorders

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