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By: Greg Stahr

PATCHED And Its Role in Basal Cell Carcinoma. By: Greg Stahr. Patched is a 12 pass transmembrane receptor:. Patched is the receptor for the key signaling protein Hedgehog. In mammals Hedgehog signaling occurs through the cilium. PTCH is key at many places in normal development. In Flies:

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By: Greg Stahr

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  1. PATCHED And Its Role in Basal Cell Carcinoma By: Greg Stahr

  2. Patched is a 12 pass transmembrane receptor:

  3. Patched is the receptor for the key signaling protein Hedgehog

  4. In mammals Hedgehog signaling occurs through the cilium

  5. PTCH is key at many places in normal development • In Flies: • Anterior posterior patterning in embryos • Wing Pattern Johnson, Milenkovic, et. Al. (Molecular Cell) • In Humans: • Somites • Neural tube • Brain Development • Holoprosencephaly • Heart Development • Many other areas of the body (http://en.wikipedia.org/wiki/Holoprosencephaly)

  6. SHH Pathway is key in Nervous system patterning in Vertebrates

  7. Basal Cell Carcinoma is the most common cancer in humans • Autosomal Dominant (http://www.sciencedirect.com/science/article/pii/S1521661610000471) • LOH at 9q22.3 (http://ghr.nlm.nih.gov/gene/PTCH1)

  8. Basal Cell Carcinoma affects the basal stem cells in the skin (https://ufandshands.org/basal-cell-carcinoma)

  9. Cyclopamine is a natural smoothened inhibitor

  10. Vismodegib is another HH/PTCH1/SMO pathway inhibitor • Typical treatment for BCCs is surgery • Inhibitor called Vismodegib shows promising results in clinical trials

  11. Works Cited • "Alkaloid." Wikipedia. Wikimedia Foundation, 04 Jan. 2013. Web. 01 Apr. 2013. <http://en.wikipedia.org/wiki/ Alkaloid>. • "Basal Cell Carcinoma." UF&Shands, The University of Florida Academic Health Center. N.p., n.d. Web. 30 Mar. 2013.https://ufandshands.org/basal-cell-carcinoma. • Gailani, Mae R. “Developmental Genes and Cancer: Role of Patched in Basal Cell Carcinoma of the Skin”. Journal of National Cancer Institute. Vol. 89, No. 15, August 6, 1997 • Gustafsson, Marcus K. “Myf is a direct target of long-range Shh signaling and Gli regulation for muscle specification”. Genes and Development. Vol 16. November 1, 2001. • "Holoprosencephaly." Wikipedia. Wikimedia Foundation, 29 Mar. 2013. Web. 30 Mar. 2013. <http://en.wikipedia.org/ wiki/Holoprosencephaly>. • Johnson RL., “In vivo functions of the patched protein”. Molecular Cell. Vol. 6, Issue 2, August 1, 2000 • Nature.com. Nature Publishing Group, n.d. Web. 01 Apr. 2013 http://www.nature.com/nature/journal/v406/n6799/fig_tab/406944a0_ft.html. • "PTCH1." - Patched 1. N.p., n.d. Web. 30 Mar. 2013. http://ghr.nlm.nih.gov/gene/PTCH1. • Ribes, Vanessa; James Briscoe. “Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning”. Cold Spring Harbor Perspectives in Biology (2009). July 15, 2009. • Robbins, David J., “The Hedgehog Signal Transduction Network”. Cell Biology. Vol. 5, Issue 246, October 16, 2011 • Tang, Jean Y., et al. “Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome”. The New England Journal of Medicine. Vol 366. June 7, 2012. • "What Are Basal and Squamous Cell Skin Cancers?" What Are Basal and Squamous Cell Skin Cancers?N.p., n.d. Web. 30 Mar. 2013. <http://www.cancer.org/cancer/skincancer-basalandsquamouscell/detailedguide/skin- cancer-basal-and-squamous-cell-what-is-basal-and-squamous-cell>.

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