Canada's Top 10 Influential Healthcare Leaders To Follow In 2022

1. Care through EI Effective Ways to Know

2. Be?er Health and a better way of life.

4. Editor’s Note Trailblazing the Community with Healthcare Excellence ith the symbolic development of technological upgrades, intellectual discourse and socio- W economic upliftment, human society has been transforming the globe with empathetic leadership. And, into this transgression, humans have been true carriers of visionary leadership. Moving ahead of the conventional approach, the community has been reinventing the existing science and coming up with novel solutions that have amazed global leaders worldwide. Referring to the globe, one of the best sectors that is revolutionized at a skyrocketing speed is healthcare. And, with the zeal of technology leadership, inclusive approach, and resilience of healthcare leaders, the care community has glorified the crown of thought leadership. Standing at the helm of this transformation is a confluence of Entrepreneurs, Medico, paramedics, Research Enthusiasts, and many more. Transforming through healthcare excellence, it is also important to look at the geostrategic merits that make the hustle easy and also support with an ecosystem where the thought leaders get guided through the vast opportunities.

5. One such region that immensely helps healthcare and its professionals through the transformation is Canada. Being a region that nurtures innovation through research, technology, and thought leadership, Canada has been a harbor to healthcare organizations. Blessed with high immigration and surplus talent pool, the region is most favorable for technology entrepreneurs. This has facilitated a healthy ecosystem for leaders of healthcare sectors with social capital, growing market, care opportunities and research-based innovations. Guided by the above metrics, healthcare leaders of Canada have been exemplifying the globe with fruition of thought leadership in care. And, known with the above development, we at Insights Care are excited to present you our latest edition, "Canada's Top 10 Influential Healthcare Leaders To Follow In 2022." While you flip through the inspiring stories of influential healthcare leaders, ensure to read the insightful articles our In-house editorial team opined. I hope you have a happy read! - Bhushan Bhad

6. Peter Li Staunch Leadership Acumen CONTENTS 08

7. 1 6 Albert Friesen Innovations Augmenting the Healthcare Space 24 Chris Perkin A Forward Thinker in the Research Space! 30 CXO All you Need to Know about your Immune System 38 Interview with Insights Care Peter Ogutu A Progressive Leader in the Global Articles Broadcasting Niche Care through EI The Role of Emotional Intelligence in the Landscape 22 of Healthcare Effective Ways to Know Leading the Modern HealthCare System 34

8. Pooja Bansal Editor-in-Chief Anish Miller Senior Editor Shrutika Khedekar Managing Editor Saloni, Drishti Assisting Editors Co-designer Art & Design Head Visualiser David King Sonia Raizada Paul Belin Art & Picture Editor Mrunalinee Deshmukh Business Development Manager Amy Jones Marketing Manager John Smith Sarah Wilson, John Smith, Alex Vincent Business Development Executives Kelli, Bill, Anna Sales Executives Technical Head Jacob Smile David, Robert Amar Sawant Technical Consultants Assistant Technical Head Alina Sege Digital Marketing Manager Renuka Kulkarni SME-SMO Executives Assistant Digital Marketing Manager Gemson Research Analyst Eric Smith Circulation Manager Tanaji Fartade sales@insightscare.com July, 2022 Contact Us: Insights Success Media Tech LLC Insights Success Media and Technology Pvt. Ltd. 555 Metro Place North, Suite 100, Office No. 22, Rainbow Plaza, Shivar Chowk, Dublin, OH 43017, United States Pimple Saudagar, Pune, Maharashtra 411017 Phone - 302-319-9947 Phone - India: 7410033802, 74100058552 Email: info@insightscare.com Email: info@insightscare.com For Subscription: www.insightscare.com For Subscription: www.insightscare.com https://twitter.com/Insightscare Follow us on : www.facebook.com/InsightsCare/ Copyright © 2022 Insights Success Media and Technology Pvt. Ltd., All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from Insights success. Reprint rights remain solely with Insights Success Media and Technology Pvt. Ltd. Insights Care is powered by Insights Success Media and Technology Pvt. Ltd.

9. Featuring Organization Brief Albert Friesen started Medicure Inc., focusing on Medicure Inc Albert Friesen developing MC-1 and learning and innovating CEO and Founder medicure.com pharmaceutical marketing. Focused on innovation, biotechnology, biomedical sciences and clinical research, Alejandro Antalich also leads Biomind Biomind Labs Alejandro Antalich Labs Inc., a Canadian publicly traded life sciences company CEO biomindlabs.com specialized in fast acting psychedelics and tailored drug delivery systems targeting specific therapeutic indications. Chris became CEO of Altasciences in 2010. He began his Altasciences Chris Perkin career at Huntingdon Life Sciences in England in 1975 as a CEO altasciences.com toxicologist. Under the leadership of Jean, Virica is using a biosensor that detects the interaction with the virus and its receptor which Virica Biotech Jean-Simon Diallo will allow them to rapidly test small molecules and drugs for CEO viricabiotech.com their ability to block the virus which is crucial not only for this pandemic, but also in the future. An accomplished biochemist, Dr. Lewis studies Rosetta Therapeutics Peter Lewis neurodegeneration, chromosome structure and function, rosettatherapeutics.com CEO gene regulation, and protein folding. Under the leadership of Peter,ABM is driven by a team of Applied Biological passionate and talented scientists and is dedicated to Peter Li Materials Inc. empowering the scientific community with the latest innovations CEO abmgood.com for life sciences research and drug development. Mr. Peter Ogutu, Producer/Director at Kenya Peter Ogutu Kenya Broadcasting Broadcasting Corporation (KBC) believes in hard work Corporation Producer/Director and creativity. Richard is well known in the natural products industry for GFR Pharmaceuticals Richard Pierce creating and marketing the most successful brand of sport gfrpharma.com Board Chair and Founder nutrition products in Canada. Seema Gupta is a President, Founder, and CTO at NanoSpeed Seema Gupta NanoSpeed Diagnostics and she has a PhD from PGI Diagnostics Inc. CEO Chandigarh. nanospeed.ca Sheldon has a successful track record of launching Sheldon Croome Atlas Growers CEO businesses and leading teams in a start-up environment. atlasgrowers.com

11. Peter Li CEO Applied Biological Materials

12. Canada’s Top 10 Influen?al Healthcare Leaders to Follow In 2022 eadership is a vital management function that helps to direct an organization's resources for improved L efficiency and the achievement of the desired goals. Effective leaders provide clarity of purpose and guide the organization to realize its mission. Successful leaders create a clear vision and mission of the firm to the subordinates, providing direction and helping the employees to act accordingly for the actualization of the objectives. The role of leadership is immense for smooth and better functioning and the importance of leadership is pivotal in accomplishing efficiency throughout the organization. With a Spark to do Things Successful leaders have inspired many with their effective abilities and skillset throughout history. The ability to Peter commenced this company with a vision to develop influence people—to motivate, energize, and direct them in and market ready-to-use biological materials so that the quest for strategic goals—is so integral to the definition scientists would not have to spend time and resources of leadership as to be virtually synonymous with it. One developing the materials themselves. such personality is Peter Li, CEO, Applied Biological Materials. Peter's career began in China, where he was initially trained in medicine with a specialization in pathology. Then, in Founded in 2004, Applied Biological Materials (ABM) Inc. 1991, he joined the Pathology Department at the UCLA has been catalyzing scientific discoveries in Life Sciences Medical Centre under a WHO fellowship program. and Drug Development for over a decade. It was there that Peter saw the first successful applications Under the leadership of Peter, the company is driven by a of recombinant DNA technology not only in medical team of passionate and talented scientists; ABM is genetics but also in the work being undertaken by different dedicated to empowering the scientific community with the labs at the UCLA Howard Hughes Research Institute for the latest innovations for life sciences research and drug ongoing human genome project at the time. development. It was such an exciting field that Peter made his decision to pursue formal PhD training in this direction. He was lucky enough to receive six offers with full PhD scholarships. He was most attracted by the opportunity to work in cancer gene therapy research in the Department of Medical Biophysics, University of Toronto. In the fall of 1994, Peter relocated from Los Angeles to Toronto to join the Department of Medical Biophysics for his PhD training. The department research labs were physically located in the Ontario Cancer Institute/Princess Margaret Hospital, a very prestigious facility in Canada and around the world. Quite a few important discoveries and inventions had been made throughout its history, including establishing cancer radiation therapy and discovering human haemopoietic stem cells, T- cell receptors, and the tumor chemo-resistant PGP protein, to name just a few.

13. Peter was surrounded by many great scientists, and a lot of exciting research projects were going on in this department. In addition, his project on breast cancer gene therapy was very exciting and progressing beyond expectations. It was such an exciting time that Peter often stayed at the lab very late – often until 4:00 am in the morning – before going home for an early breakfast and a few hours of sleep. His professor and the institute gave him complete freedom to design and test projects and experiments. Even today, Peter considers those years the best time of his life. The solid training that he received from this program prepared him well to take on a career or be an entrepreneur in the biotech industry. Embracing the Opportunities After completing the PhD training, Peter entered the biotech industry in 1999 as a Scientist at Clontech Laboratory Inc. in the Bay Area, developing adenoviral By 2003, Peter had been working in the Bay Area for vectors. After exactly one year, he served as a Research almost four years, and he saw the biotech industry boom, Scientist at Sangamo Biosciences Inc. inspiring Peter to start his biotech company. (NASDAQ: SGMO), developing therapeutic After evaluating many different factors, he finally chose to viral vectors for zinc finger protein relocate to Vancouver, Canada, and start Applied Biological therapy. Materials Inc. (ABM) with a vision to develop and market ready-to-use biological materials so that scientists would not have to spend time and resources developing the materials themselves. Specifically, the company offers ready-made biological

14. Pearls of Wisdom Sharing opinions on the necessity for life sciences research and drug development service providers to align their offerings with newer technological developments, Peter said, the fundamental necessity for life science research and drug development service providers is to make research and drug development easier and simpler, i.e., to streamline their project workflow. For example, there is a desperate need for COVID-19 cell lines and animal models to aid in COVID-19 research and drug development. Moreover, in Peter's opinion, the COVID-19 pandemic will significantly impact future biotech research. Emerging and hot areas of research and development, such materials under the following three categories: general as cancer immunotherapy, gene therapy, and CAR-T cell biological materials (PCR enzymes, transfection reagents, therapy, are bound to continue to be hot. But a significant and others), cellular materials (a curated list of specialized amount of funding resources will be placed into research on cell lines), and genetic materials (all cDNA, genes, siRNA, the COVID-19 virus to better understand the virus's basic miRNA, and UTRs for each human, mouse, and rat gene). biology, epidemiology, and immunology and develop better therapeutics. The story of the company's founding is a very humble one: Peter only had access to $20K in start-up funding and a 500 COVID-19 vaccine development will be one of the most sq. ft. laboratory. During the first year of operation, he was important areas of development. Although the FDA has the sole employee, doing everything from product already approved several vaccines, there will be an ongoing development, product production, and QC to business effort to learn more and develop better vaccines. development, accounting, and shipping/logistics. Sharing his advice for the budding entrepreneurs as an Later, with funding from Industry Canada's IRAP program experienced professional, Peter said, "The biotech industry (like the US small business innovation grant), he grew the is thriving and full of entrepreneurial opportunities, but it company by +20% every year until the COVID-19 also happens to be a resource-intensive area (in terms of pandemic hit North America in 2020. Later, Applied both human and capital resources), thus developing an Biological Materials created job opportunities for over 150 R&D strategy that is focused and in-sync with market full-time employee's pre-pandemic, with a current demands is key to anyone who wishes to succeed in this employee count in excess of 120. sector.” Exemplifying Contribution Surmounting the Challenges As a provider of biological materials, Applied Biological Peter's biggest challenge is to develop a longer-term and Materials have provided enzymes that IVD companies can bigger picture perspective for the company – specifically use to develop COVID-19 qPCR tests as well as developing when it comes to deciding the right product categories to its own COVID-19 qPCR products accredited with both CE focus on. As a scientist-derived entrepreneur, his interests and FDA EUA authorization to help its customers to are often too broad, leading to a lack of focus for his surmount the adversities of the pandemic. business operations. The company also offered basic research materials for However, he believes that the business could have been studying the COVID-19 SARS-CoV-2 virus, such as RNA, much bigger and better if he had come to this realization ten cDNA, and other products.

15. Since its incep?on, these tes?monials prove that Applied Biological Materials' significant and exponen?al achievements are reaching greater heights. years ago. Peter is still adjusting to this new mode of "Although there are alterna?ves for custom len?virus produc?on, I have found ABM to offer the best price and thinking and has been reflecting deeply on this to ensure his service to produce high ?ter len?virus preps. business operation is well focused in the future. If I have any special needs or concerns, they are always dealt with by the Technical Support Team. I have always Embracing the Future Roadmap been pleased with the product and will con?nue to use this service for my research.” Peter's hope and dream are to reach a stage where he can Ÿ Florida Department of Agriculture & Consumer Services, become less involved in daily business operations and Custom Len?virus Produc?on instead focus more on developing the company's corporate "We are very glad to have enjoyed the len?virus packaging strategy. services from Applied Biological Materials Inc. When we received high ?ter len?virus produc?on (10^10 ABM is on track to be able to scale up in the next five IU/mL) from Applied Biological Materials Inc for in vivo experiment and then injected the scia?c nerve of a mouse years, and the key to a successful scale-up is strict product with viral par?cles to the overexpression target gene in QC control and a good business development strategy. myelinated nerves. I am very surprised that the high ?ter len?virus enables rapid and efficient overexpression of a target gene in infec?ng Schwann cells of wild type mouse.” “The len?virus packaging service is an excellent service that I highly recommend.” Ÿ Wayne State University, High-Titer Custom Recombinant Len?virus "Always amazed at the reasonable prices and breadth of selec?on for genes of interest available on your site. Thanks very much!" Ÿ Washington University in St. Louis, CNNM1 Adenovirus (Mouse)

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18. Albert D. Friesen CEO and Founder Medicure Inc

19. Canada’s Top 10 Influen?al Healthcare Leaders to follow in 2022 Innovations Augmenting the Healthcare Space he major advancements in the healthcare industry In an interview with Insights Care, Albert sheds light on with research and development that are being Medicure's journey, its vision and core values, and his T implemented significantly over the past few opinions on the company's future. decades have introduced new platforms enabling reliability in the niche. Albert, can you please tell us about your journey as the CEO and Founder of Medicure Inc. However, the cost of prescription drugs is growing at an unsustainable rate, making it difficult for patients to access With a PhD from the Department of Chemistry, University the medicines they need. Comprehending this scenario, one of Manitoba, I began a career in the pharmaceutical of the progressive technology models that have evolved in business as the first employee of the Winnipeg Rh Institute, the last few years is Telemedicine which has enabled where I led the development of WinRho. This drug prevents accessibility in reaching renowned doctors to patients. Rh Disease in the Newborn. The recent innovation that has positioned itself as an attractive model in the healthcare industry is e-pharmacy. Over a 20-year career with the Rh Institute, as President, I led the development of several other plasma products and These pharmacies can effectively address multiple issues pharmaceutical manufacturing facilities. The Winnipeg Rh that healthcare consumers and the system face repeatedly. Institute became Cangene, and now Emergent BioSolutions. It enables consumers to order medicines conveniently and In the 1980s 1990s, I started several biotech companies, the aggregates supply with an efficient infrastructure that first ABI Biotechnology Inc., which became Apotex provides value-added information to consumers, such as Fermentation and now Cronos. Other companies I started drug interactions and their side effects. Moreover, an online pharmacy model enables existing pharmacies to start online functioning and serve a broader set of customers. A network of pharmacies integrates into one platform and access a wider customer base while also Medicurecan help bridge ensuring that the inventory is consolidated. Enabling a that gap between plethora of such reliable services, Medicure excels in the healthcare providers limelight of the healthcare industry. and patients using open Under the leadership of Albert D. Friesen, CEO, and and honest Founder, Medicure's sales force markets to physicians and communication. other healthcare professionals. E-Commerce integration offers patients and providers direct online ordering and home delivery byproviding a growing portfolio of products that improve patients' lives. www.insightscare.com July | 2022 17

20. are DiaMedica Inc. and Novopharm Biotech, which became Our vision is to become a leading pharmaceutical company Viventia and now Sesen Bio. within the U.S., offering a growing portfolio of products that improve patients' lives. In 1997 I started Medicure Inc., focusing on developing MC-1 and learning and innovating pharmaceutical We are actively developing new products (MC-1 and marketing. My previous career had been in drug several generics), promoting our current portfolio development and manufacturing believed that there would (Aggrastat, Zypitamag), and creating innovative solutions be interesting opportunities in innovating the marketing of for patients to enable them access to life-saving medications drugs in the USA market. through our E-Commerce pharmacy platform Marley Drug. What are the core values upon which your organization Can you elaborate more on the benefits it is providing is built? Can you elaborate on the mission of Medicure both patients and healthcare and how is it making an Inc.? impact on the pharmaceutical industry? We believe strongly that all patients should have access to The cost of medications affects patients' compliance and, affordable and life-changing medications. It's precisely why ultimately, their overall health. No other industry would one Medicure ventured into the online pharmacy world with the provide a customer something, in this case, medications, purchase of Marley Drug® in December of 2020. without knowing how much they are paying for it, if they purchased it, and if they are using it. Customers are longing for businesses to operate with integrity regarding drug pricing in the U.S. Integrity is one We can help bridge that gap between healthcare providers of our core values at Medicure. We say what we do, and we and patients using open and honest communication. We do what we say. Innovation is another of our core values at work with healthcare providers to let them know if their Medicure. patients are, in fact, filling their prescriptions. We also provide patients with transparent pricing with no hidden As a company, we find innovative ways to serve patients fees. It's a win-win for healthcare providers and patients. and healthcare providers; whether it's through developing new medications, like MC-1 to treat a rare form of epilepsy Our Medicure model helps build trust with both healthcare caused by a genetic Pyridox(am)Ine 5'-Phosphate Oxidase providers and patients. Trust is so important in healthcare. It (PNPO) deficiency or strategically purchasing and allows for open communication and better patient promoting mature products in new ways, like Aggrastat® outcomes. (tirofiban hydrochloride) injection, or by creating solutions to supply chain issues by purchasing Marley Drug and Being an experienced leader, what were the biggest developing an E-Commerce solution for patients to bypass challenges you faced in the pharmaceutical niche and insurance company/pharmacy benefit manager middlemen what were the ways you opted to overcome them. for our other therapy Zypitamag® (pitavastatin) tablets and generic medication, as a whole. When we launched Aggrastat, we were selling to hospitals, a sell most of us could understand. The customer cared Tell us more about Medicure Inc.'s vision and how it about the efficacy and safety of the medication as well as provides safe and cost-effective pharmaceutical products the cost. We did very well with Aggrastat growing its in the US market. market share from 2% to 65% from 2014 to 2018. Medicure is a pharmaceutical company focused on the We experienced significant challenges in market access development and commercialization of innovative and when we purchased Zypitamag and entered the primary affordable therapeutics for the U.S. market. care market. We had more than just healthcare providers to convince, we also had patients and insurance Medicure's sales force markets to physicians and other companies/pharmacy benefit managers (PBMs) to convince. healthcare professionals and with an E-Commerce integration offering patients and providers direct online We soon learned, especially for this medication, which is a ordering and home delivery without the need for insurance. pharmaceutical alternative to another expensive statin, www.insightscare.com July | 2022 18

21. We are constantly consulting with patients and healthcare providers to understand what issues they are facing. They know best, and we rely a lot on their feedback. So, my advice would be to never stop asking questions and always seek solutions to complex problems. How do you envision further strengthening Medicure Inc.'s stronghold in 2022 and beyond? One of Medicure's main focuses is carrying out a Phase 3 clinical trial with MC-1 for the treatment of a genetic disorder referred to as PNPO deficiency which is a rare neurometabolic disease that presents with severe neonatal epilepsy. The completion and subsequent approval can really accelerate our growth at Medicure. The FDA has a Rare Pediatric Disease Priority Review Vouchers program, and Medicure has qualified that when MC-1 is approved for the PNPO indication, the FDA will issue us a voucher to accelerate the approval process. These vouchers sell for between US$100 million and US$200 million, meaning that once we finish our Phase 3 trial and obtain approval, we will receive a voucher worth in excess of US$100 million that will provide us with further non-dilutive capital. In addition, we believe that our Livalo®, access is everything. If patients cannot access it or recently launched e-commerce site for Marley Drug has afford it, they won't buy it. enormous potential and will be our most significant driver of growth and significant source of our profits moving We launched Zypitamag at a price point of roughly 50% forward. less than Livalo® expecting a quick adoption by insurance companies and PBMs. This was not the case, even when we offered the PBMs high discounts on top of this lower price. We soon learned the fastest and most profitable way for us to get this medication to patients was to sell it to them directly. So, what we did was we purchased a pharmacy, Marley Drug, which can sell Zypitamag directly to patients for just $1 per day. Since then, we've seen a 10-fold increase in our sales, and this continues to rise steadily each month. As an industry professional, what would be your advice to the budding entrepreneurs and enthusiasts aspiring to venture into the pharmaceutical industry? You always want to be solving a problem. What is the healthcare system missing, and can we help? www.insightscare.com July | 2022 19

24. TheRole of ntil decades ago, hospital Emotional settings were perceived as U workplaces that emphasised Intelligence in crisp efficiency. Emotions were still far away from any consideration, being perceived as – “irrational” or the Landscape “feminine.” of “But displaying emotions is merely a social convention for discussing Healthcare behavioral intentions,” argues Deeba Hasan in a 2018 research study. In a healthcare setting, conventional ways of care are being questioned, debating over the need for emotion in delivering care. Even if emotions were essential, to what extent is it suitable to rely on emotions? Taking instances from the Uk’s health services, the criticism points out that the healthcare professionals display a www.insightscare.com July | 2022 22

25. lack of compassion and care, leading to adverse outcomes Despite evidence that highlight the need of emotional among patients. If so, is there an association between intelligence for effective patient care, attention must still be professionals' ability to care with their level of emotional given to where the health care professionals stand. intelligence? Otherwise, it would just be a neglect of their personal sense of being. Changing times have reflected that “emotional intelligence is the key to successful communication,” suggests Deepa. Physicians, nurses, and doctors – are healthcare Patients today demand their rights as consumers. A priority professionals who are required to be both – clinically is placed – not on having their physical needs met, but competent and emphatic towards patients. “In practice, rather their emotional needs. however, accommodating both could be difficult,” says Angeliki Kerasidou, in a 2016 report in BMC Medical Let’s dive in to evaluate the role of emotional intelligence Ethics. in healthcare. It makes sense, as they are required to be technically skilful What Do Patients Need? and rational towards patients’ concerns while maintaining a detached emotional presence. This certainly inhibits them A frequent level of complaints that patients hold – is not from not feeling patients' or their own feelings. related to doctors’ clinical competence, but to their poor communication. Addressing Patients’ Needs “Patients require care that is respectful and responsive to Focusing on the debate over emotional intelligence, views individual patient preferences, needs, and values,” go beyond the rigid boundaries of empathy and compassion emphasizes Sanne Kuipers, in a 2019 study. But traditional yet interconnecting with empathic interactions. For this forms of healthcare aren’t responsive to these needs, rather reason, Clarissa Guidi, in a 2021 study, proposes ‘empathic simply targeting a disease-oriented concern. concern’ over ‘clinical empathy.’ She states that empathic concern would mean – an expression of genuine interest towards patients’ experiences. With regards to responding to patients, Yvonne Birks, a researcher at the Journal of Medicine suggests, “If clinicians were able to understand patients’ emotional Healthcare professionals are encouraged to incorporate reactions, then they’d be in a better position to understand emotional intelligence through ‘engaged curiosity’ where why some treatments are more acceptable to patients, than they demonstrate an emotionally engaged interest in others.” This makes sense as -- even though a doctor may learning about their patients' emotional points of view. be listening to the patient’s complaints, for the patient to know that the doctor understands his concerns, it could only “However, such a concern is different from a ‘detached be through responding effectively. concern’ as it means – a commitment to validating patients' needs,” emphasises Clarissa. “Emotional Detachment” Is a Changing Norm Wrapping up The shortage of compassion and empathy, the two aspects of emotional intelligence, has been intensely recognized by Situations arise where emotional intelligence would simply the Western medical culture. Similarly, attempts have been require the healthcare professional to acknowledge the made to reintroduce compassion within the healthcare patient as a human being – with feelings and self-worth. sector. However, the pre-established structure of care relies That being said, patients appreciate their doctors' curiosity on “detachment” as an ethic, which has been admitted as an over their health. error. Despite the reference to understanding their patients better, But empathy is still about understanding the patient – a Angeliki suggests, “Emotional intelligence must not be genuine emotional response that recognizes patients. something to be expected from healthcare professionals. “Patients are desirous and hungry for being understood and Rather, it must be actively promoted, assisted, and recognized,” highlights a 2021 study. cultivated within the healthcare profession.” - Saloni Agarwal www.insightscare.com July | 2022 23

26. Canada's Top 10 Influential Healthcare Leaders To Follow In 2022 Chris Perkin A Forward Thinker in the Research Space! John C Maxwell rightly said, "A leader worked my way up to Director of with ONE truly integrated and full- is the one who knows the way, goes the Toxicology and then to General service CRO/CDMO to move a drug way, and shows the way.” Manager, and then Chief Operating from the preclinical phase to clinical Officer. proof of concept, and beyond — This quote goes very well for Chris seamlessly. Perkin, the CEO of Altasciences. When I joined Altasciences, I assembled a team to implement a new And that's what we've done; we created espite being part of a very vision for outsourcing which was to a truly integrated, end-to-end drug regulated industry that prefers create a unique paradigm, so that drug development solution company! D to stick to the status quo, development sponsors could partner Chris is a leader focused on innovation and out-of-the-box thinking. Even though faced with a lot of skepticism, he managed to implement a new vision for outsourcing, by creating a unique and truly integrated one-stop drug development solution for biopharmaceutical companies worldwide. While in a conversation with Insights Care, Chris describes his journey and the flexible solution provided to sponsors by Altasciences. Below are the interview highlights: Chris, please give us a brief overview of your journey as the CEO of Altasciences. I joined Altasciences in 2010. I have been in the CRO industry for almost 50 years, with a quick stop in pharma along the way. I started my career as a Preclinical Study Director in 1975 in England at Huntingdon Research Centre before moving to Bioresearch in Montreal in 1988. From there, I www.insightscare.com July | 2022 24

27. Don't be afraid to change things and question the status quo – to innovate, to take chances, to choose your Chris Perkin CEO own path. Altasciences What are the core values upon which Altasciences is built, and what is the mission of the organization? Our mission is straightforward: we help sponsors reach critical drug development decision-making milestones faster by improving the speed and ease of the overall process. We bring all the traditionally separate early phase drug development steps under one CRO/CDMO — with teams and systems that actually talk to each other, and centrally coordinated operations. Hence, clients never have to repeat themselves as they move their new drug through the development process. This removes the need for multiple service providers and, in turn, helps our clients get better drugs to the people who need them, faster. At Altasciences, our projects with clients are not just transactions — they are partnerships. We are here to help them bring their drugs to market; their goals are our goals. We believe in communication, transparency, dependability, honesty, and good science. And because we often collaborate with sponsors on more than one phase of a program, we really get to know them and every detail of their projects, and are better positioned to

28. support them through the various As part of the Proactive Drug gain experience, often through the stages of early phase drug Development solution, activities occur school of hard knocks, you either learn development. We call this moving in in parallel rather than sequentially, and move on to new challenges or you unison to deliver a big impact with a ensuring a smoother and faster don't, which is okay if that's what you personal touch. transition into the next stages. With the want. efficiencies produced by using Tell us more about Altasciences, its Altasciences for all early phase drug I encountered a lot of resistance to new vision, and how it provides research, development, we can reduce R&D ideas in the early days of my career, manufacturing, and analytical timelines by up to 40%, without and still do, to a lesser extent, but services to biopharmaceutical cutting corners. We have built a whole obviously, the title of CEO helps these companies. new, seamless, more proactive days. For me, perseverance and outsourcing experience for the industry patience were key factors. I have only We look at drug development as a with these three words. worked at four companies in over 50 single continuum instead of a series of years; I left the first two because I had steps. And our vision is to be (and, in Chris, being an experienced leader, progressed as far as I could and learned fact, we are!) the one-stop solution for what were the initial challenges that all that I could. early phase drug development. We you encountered following the offer the full spectrum of solutions biggest challenges on the way ahead, I left the third company because, within one CRO/CDMO: preclinical and what were the ways you opted to although I was an executive, the research, clinical research, bioanalysis, overcome these? company was pushing me in a drug manufacturing and formulation, direction that I did not feel was where I medical writing, regulatory guidance, Challenges change depending on wanted to go. So, at 59 years of age, I biostatistics, program management, where you are in your career. As you moved to what was to become data management, and so much more, all of which are tailored to a client's specific study requirements. And we provide these services whether for one study, a suite of services, or an end-to-end program — we offer sponsors complete flexibility. And all these services can be provided to a client with the support and guidance of a single project manager – no handoffs. Elaborate on the solutions and services that Altasciences has provided under your leadership. I'll give you three words: Proactive Drug Development. These words encapsulate our approach and our promise to our partners. We handle all early phase CRO and CDMO activities for sponsors; we synchronize our services for optimal communication and collaboration to mitigate risk, condense timelines, and save our clients' money. www.insightscare.com July | 2022 26

29. were able to prove that there is another way to outsource contract research; we don't have to settle for the status quo. How do you envision further strengthening Altasciences' stronghold in 2022 and beyond? Altasciences has evolved and will continue to evolve because we are continuously looking for ways to improve the drug development journey for our clients. We're not afraid to ask what they need from us. With that, we've sought to fill gaps in our services and expertise through acquisitions and organic growth. Since 2010, we've built Altasciences into a full-service solution with eight locations, coast to coast. We'll continue to develop our portfolio in North America and will be building the same model in Europe by acquiring facilities that align with our vision and culture. And we will continue to invest in ourselves with the latest equipment and expansions (like the one we completed Altasciences, and we built a whole new change our culture so that everyone, at at our bioanalytical lab in Laval, approach to drug development. That's every level, feels part of the plan and Quebec, and at our CDMO site in what I mean by persevering and shares in the success. Philadelphia just last year). And we'll making the right decisions for you to continue to invest in our team through get where you want to be. As an established industry leader, employee development initiatives; our what would be your advice to the Altascientists (as we like to call them) At Altasciences, the challenges over budding entrepreneurs and are the best in the business, and they the last 12 years have been to instill enthusiasts aspiring to venture into truly make all the difference. belief in our managers, staff, and the research space? investors that we have truly created a Every move we make is a step toward different kind of CRO/CDMO. I Don't be afraid to change things and further streamlining the outsourcing overcame that resistance by being the question the status quo – to innovate, paradigm to provide our partners with face and voice of the new approach, to take chances, to choose your own an even more comprehensive and not just to staff and investors but to path. Change is slow in an industry like proactive drug development journey. anyone who would listen. ours, and the proven, established And as we continue to grow, we will standard is often preferred over out-of- maintain our company culture of It was also by making the plan logical, the-box thinking. When I started on my collaboration, integration, and ensuring everyone, especially those at vision for Altasciences, we received a customer focus. Altasciences, understood what we were lot of raised eyebrows, questions, and doing and why. Over the past 10 years, skepticism because "no one had done it I have increasingly used before", but through passion, communication in all its forms to determination, and innovation, we www.insightscare.com July | 2022 27

32. n this article, we will discuss all you need to know Ÿ Vaccinated immunity about the immune system, that is; how the immune I system works, types of the immune system, part of the This is acquired through the introduction of a killed or immune system, a weak immune system, and how to boost weakened form of the disease organism through the immune system. Kindly pull a chair, a pen, and a book vaccination. as you read on. Ÿ Natural immunity How does the immune system work? This is acquired through exposure to a disease organism Memory cells are two various subtypes of white blood cells through infection with the actual disease. So if the body is (B-lymphocytes and T-lymphocytes) that the immune exposed to a foreign invader(disease organism), the system uses to keep a log of every pathogen it has ever immune system recognizes it and produces the antibody eliminated. If the microbe enters the body again, it will be that will fight it. Active immunity lasts long in the body. immediately recognized and destroyed before it has a chance to grow and make you sick. If you are not in good Ÿ Passive immune system health, your immune system might be unable to defend against foreign invaders. With this kind of immune system, antibodies are given to a person based on the disease organism present in their body. Additionally, the immune system may continue to attack Instead of being produced by the immune system itself, this even in the absence of an outside intruder or after an sort of immune system is supplied. outside invader has been killed, which can cause allergic reactions and autoimmune illnesses. While the immune system takes some time to create active immunity, passive immunity can be given or administered What are the types of immune systems? right away. There are two types of immune systems: The active Parts of the immune system immune system and the Passive immune system. The main parts of the immune system include Bone Ÿ Active Immune system marrow, lymphatic system, tonsils and Adenoids, thymus, white blood cells, and spleen. This type of immune system is triggered to produce antibodies to tackle a particular disease organism when the Ÿ Bone marrow body is exposed to it. The active immune system can be acquired through vaccinated immunity or natural immunity. This spongy tissue, which is located in the bone, creates various immune cells, including white blood cells, platelets www.insightscare.com July | 2022 30

33. Author Bio Author Bio OLUWASOLA SAMUEL Oluwasola is a health content writer. In addition to this, he works as a financial sales associate (Insurance sales associate). His experience in the insurance industry has made him more aware of the careless and dismissive ways in which some people have approached health issues. As a health advocate and educator, Oluwasola uses well-researched information to guide the audience in making wise health decisions that improve their quality of life. Oluwasola possesses communication, research, adaptability, and originality skills. All of these help him craft great content that resonates, sweeps his audience off their feet, and communicates effectively. He also crafts content that addresses the pain points of his audience. that aid in blood clotting, and red blood cells that carry trapped, and immune cells start producing antibodies to oxygen. Every day, the bone marrow creates billions of red fight the invaders. blood cells. Ÿ Thymus Ÿ Lymphatic system Above the heart, in the upper part of the chest, is where you This is a collection of lymph nodes, lymphatic veins, and can find this white blood cell. Its main duty is to become white blood cells that are found throughout the body. They more familiar with, identify, and remember an invader so all cooperate to control the body's fluid balance, absorb that it can rapidly deal with the invader. dietary fat in the intestine, kill bacteria, and deal with cancer cells. Ÿ White blood cells Ÿ Tonsils and Adenoids These are vital components of the lymphatic system, and the immune system depends on them. They circulate The nasal tube and throat contain this immune system through the body's bloodstream in search of foreign component. It prevents bacteria from entering the body invaders (bacteria, parasites, or viruses), and when they through the nose or mouth. When a virus or bacteria enters encounter any invader, they launch an urgent and the body through the mouth or nose, it is immediately immediate attack. www.insightscare.com July | 2022 31

34. Ÿ Spleen Ways you might be harming your immune system: Red blood cells are filtered by the spleen, which also Ÿ Smoking damages and eliminates any damaged old red blood cells. Additionally, it houses the white blood cells necessary to More than 7,000 chemicals and chemical compounds in cigarettes affect the immune system. The CDC estimates defend against outside invaders. that smoking causes almost 500,000 American deaths per What is a weak immune system? year. At least one significant disease brought on by smoking affects 16 million additional Americans. Avoid smoking if This means your immune system can no longer launch an you desire a healthy lifestyle. attack on foreign invaders(bacteria, viruses, and fungi) in your body. A weak immune system means you are prone to Ÿ Stress and Anxiety frequent infections, and you are immunocompromised. We live in the jet age, where everything moves fast. You A weak immune system can be caused by the following: constantly want to be aware of both work and personal events. As a result, you might find out you are tense and Ÿ Malnutrition stressed. Stress increases catecholamine and suppressor T cell levels, which suppress the immune system making you Ÿ Health condition more susceptible to infections. It makes persons who are overweight more likely to develop diabetes mellitus. Ÿ Lifestyle Ÿ Lack of Exercise Ÿ Aids The likelihood of getting sick regularly is increased among Ÿ Diabetes people who rarely exercise. Obesity, heart disease, diabetes, high blood pressure, and high cholesterol levels are all risks Ÿ Cancer for people who don't exercise regularly. Ÿ Immunosuppressive drugs Ÿ Dehydration Ÿ Organ transplant Since water makes up between 50 - 70 percent of the weight of an adult human, it is vital to our health. To remain Ÿ Cancer active and perform as intended, our cells and organs require water. Dehydration and lightheadedness can result from not drinking enough water. According to the U.S. National Additionally, your immune system can deteriorate over time due to aging. People aged 70 and older begin to experience Academies of Sciences, Engineering, and Medicine, the immunodeficiency. following amounts of fluid should be consumed each day: Signs that your immune system is weak. About 15.5 cups (3.7 liters) of fluids a day for men. People who suffer from a weak immune system encounter About 11.5 cups (2.7 liters) of fluids a day for women. frequent and different signs such as: Ÿ Unhealthy Diet Ÿ Pneumonia Ÿ Body pain Children that eat well grow up, stay healthy and have Ÿ Inflammation of internal organ stronger immune systems. It lessens their vulnerability to illness. A nutritious diet helps adults avoid becoming obese Ÿ Growth and development in children and lowers their chances of developing chronic diseases. Ÿ Cough Those with existing medical issues benefit from a healthy diet. It aids them in controlling their illness. Ÿ Fever 03| MM 2022|www.insightscare.com

35. Ÿ Lack of Sleep References: Your immune system might be harmed by lack of sleep. Ÿ National institute of health(NIH)- Immune System Lack of sleep promotes the production of inflammatory https://www.cancer.gov/publications/dictionaries/cancer- cytokines, which raises your risk of diabetes, high blood terms/def/immune-system pressure, heart attack, heart failure, and stroke. Ÿ Institute for Quality and Efficiency in Health Care- How Ÿ Alcohol does the immune system work? https://www.ncbi.nlm.nih.gov/books/NBK279364/ Alcohol abuse damages the immune systems over time. A weakened immune system increases a person's vulnerability Ÿ Centers for disease control and prevention(CDC)- to pneumonia, flu, and other infections. In the United Immunity type States, from 2015 to 2019, excessive alcohol use caused https://www.cdc.gov/vaccines/vac-gen/immunity-types.htm more than 140,000 deaths and 3.6 million years of lost Ÿ What's immune system-National Library of Medicine. potential life annually, shortening the lives of those who died by an average of 26 years, according to the CDC. https://www.ncbi.nlm.nih.gov/books/NBK10759/def- item/A2921/ How to boost your immune system? Ÿ Immunocompromised-National institute of health(NIH) The following are the ways you can boost your immune https://www.cancer.gov/publications/dictionaries/cancer- system: terms/def/immunocompromised Ÿ Exercise regularly Ÿ Encarnacion Montecino-Rodriguez, Beata Berent-Maoz, and Kenneth Dorshkind-Causes, consequences, and Ÿ Maintain a healthy lifestyle reversal of immune system aging https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582124/ Ÿ Get vaccinated Ÿ Centers for Disease Control and Prevention(CDC)- Ÿ Reduce stress Smoking and overall health. https://www.cdc.gov/tobacco/data_statistics/sgr/50th- Ÿ Get enough sleep anniversary/pdfs/fs_smoking_overall_health_508.pdf Ÿ Stay hydrated always Ÿ Mohd. Razali Salleh- Life event- Stress and illness. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341916/ Summary Ÿ Centers for disease control and prevention(CDC) - The immune system serves as the first line of defense Physical inactivity https://www.cdc.gov/chronicdisease/resources/publications/ against external intruders (viruses, bacteria, and fungi). It investigates, finds, and attacks the outside invader. A factsheets/physical-activity.htm healthy individual who engages in regular exercise consumes a nutritious diet, and abstains from smoking and Ÿ Centers for Disease Control and Prevention(CDC)-Poor binge drinking will not frequently contract illnesses. nutrition https://www.cdc.gov/chronicdisease/resources/publications/ factsheets/nutrition.htm For your immune system to combat and kill foreign invaders in your body, you must make sure you lead a healthy lifestyle. Ÿ Centers for Disease Control and Prevention(CDC)- Sleep and the immune system Please contact an immunologist if you have https://www.cdc.gov/niosh/work-hour-training-for- immunodeficiency (deficiency of the immune system). An nurses/longhours/mod2/06.html immunologist is an expert in immunodeficiency disorders. Ÿ Centers for Disease Control and Prevention (CDC)- Alcohol use and your health https://www.cdc.gov/alcohol/fact-sheets/alcohol-use.htm www.insightscare.com July | 2022 33

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37. Leadg the Modern HealthCa System deating minds combined with experimenting hands is Let us dive straight into the article and know the How! what may be the key that leads the journey of I becoming a leader from the crowd. This concoction has Effective Ways to Know empowered the masses to rise above the ordinary and has transformed the world in a myriad of positive ways. Build and Train the Mindset Talking of transformations, one segment in the limelight is The cycle of cognition, actions and behaviors is intertwined the healthcare sector which has witnessed many eminent as one affects the other. Therefore, it becomes essential to personalities of yesterday as well as of the present who build a mindset that will ensure discipline, consistency and have infused their leadership skills in this niche to give a intrinsic motivation in the path of becoming a leader. better life to the global population. And speaking about leaders, well who could forget the efforts of Florence It is also important to do so because the healthcare sector is Nightingale or Edward Jenner or Srushuta or Hippocrates, posed by a variety of challenges every single day. The most and others in the endless list, who have upgraded the health recent example would be the scenes of emergency, and ecosystem. scare caused by the COVID pandemic. These leaders changed the luck of many lives by striving As a leader, in such scenarios, it is important to maintain hard to provide innovative inputs in the healthcare world the calm within so as to manage the situation in a better and surely has inspired many, even today, to opt for medical way and guide fellow doctors and patients to peace and sciences or aspire to be a guiding force in the industry. Who assure them relief soon by at least handling the situation knows! with empathy. But one would definitely pause and ponder upon the These traits can only be developed when one has trained the question – What exactly made them a leader and how can I mind enough to effectively regulate emotions and display be a driver of change in healthcare? effective body language that people in crucial situations can trust. If this is what has exactly brushed past, then this is the article to stop at and read. One way to train and build such a mindset is to read about the experiences of other leaders or practice it during the This insightful piece brings some effective ways in which initial years. one can practice to lead the dynamic modern healthcare system, and flood it with innovative transformations! www.insightscare.com July | 2022 35

38. Inculcate Words, Learn by Experiences This practice will also keep one abreast of the latest happenings in the segment and never know it could lead to Books are human's best friend and practice translates one's ground-breaking innovative ideas and discover a new abilities into perfection – are the common phrases that fall hidden leader! on the ears every now and then. And hence, inculcating them would be one of the best ways of leading the modern Mentor Yourself as well as for Others healthcare system. Amongst the traits that define a leader, the trait of empathy The ever-evolving nature of parasitic infections, or modern and mentorship would top the list. Being able to convey viruses have the potential to tamper with the balanced what one has to say and communicate with the audience world, like the bubonic plague, or the recent monkeypox effectively is a good way to guide the masses in the right virus. But what made global citizens sail through and live direction. longer was the interventions by leaders. In the health ecosystem, patients are mostly confused or Now how did they achieve this, even when it was a totally grasped by fear and anxiety or are overwhelmed by the out- new event? of-pocket expenditures. In such cases, prior experience of mentoring and guiding a bunch of juniors or any group The answer lies in the phrases quoted above – books, and would prove to be beneficial as it fills one with ideas and practice. Inculcating the habit of reading apart from the ways to communicate while being calm, empathetic and normal course material will upgrade and enhance textual also delivering effectively and rightly. knowledge. While practicing it would activate learning processes that hit the long-term memory and advance one to Climbing the Success Ladders act instantaneously when abrupt situations arise. In order to lead the modern healthcare system, one has to To initiate this process, one can follow the pointers delve in deeper, to understand how the system actually mentioned below, works and responds. Learning about the ground realities and the surrounding clouds of socio-economic factors could Ÿ Start small with reading new material for five minutes initiate a new wave of thinking strings that could have the every day and pace up every day by increasing the potential to guide the technologically advanced, and reading time dynamic medical world. Ÿ Be curious and take advantage of the modern telephonic devices to solve the puzzles of information and quick The world awaits more leaders, and you definitely can be st research works the one to upgrade the face of 21 century healthcare! Ÿ Be disciplined, take new patients, diagnose the care thoroughly and apply the theoretical knowledge learnt so far - Drishti Gaikwad Ÿ Be one's own mentor – keep teaching and keep learning Ÿ Read autobiographies of personalities, learn from their experiences and try to imbibe the same attitude with the needed customizations Apart from this, it is also essential to practice a healthy lifestyle that would inspire others to do so and keep one away from any unwanted circumstances in their journey of becoming a leader. Another way to inculcate this is with the help of networking. Use social media to connect with present medical leaders, watch their inspiring interviews, or infuse their magical success chants into the journey. www.insightscare.com July | 2022 36

40. A Progressive Leader in the Global Broadcasting Niche assion and hard work are the elements that, once Media is one of the most powerful instruments of mixed, initiate the solution to success. For the communication. I have always believed in making change P achievement of it, one requires absolute devotion and empowering people. I believe in the power of one, that and strong will. A will that is possessed by everyone, but one person, one action, can have a ripple effect that can only some have the ability to see and use. The spirit of make a difference. never giving up is the key to the door that has been shut for ages. Being a Producer/Director at Kenya Broadcasting Corporation, how do you envision growing your Breaking the ordinary benchmark and opening the doors network operations into the broadcasting niche? that have been the roadblock to success is an extraordinary and multitalented person—Mr. Peter Ogutu, Being a state corporation, KBC enjoyed monopoly status Producer/Director at Kenya Broadcasting Corporation for over six decades. However, liberalization of the (KBC) who believes in hard work and creativity. airwaves in the 1990s saw the licensing of more broadcasting stations thus introducing competition and KBC has a goal to provide leadership in the transmission of growth in the industry, and this growth has given rise to objective, informative, educative, and entertaining content various digital TV shows and online stations, as KBC we to the public through high-quality broadcasts and with the are bridging the gap by also going digital via our website progressive leadership of its Director. and YouTube channel to retain our audience who switched to the various platforms. Mr. Ogutu learned about his skills and potential at a very young age, and since then, he has never looked back. He How does your medium of Kenya Broadcasting has been using his strengths as a shield to eliminate the Corporation help spread healthcare awareness and thus obstacles that have been in his way. positively impact the healthcare space in Kenya? What could be the primary strengthening elements? As the National broadcaster, it is our mandate to educate and spread awareness on healthcare and we do this through Let's merge into the interview to find out: our various TV and Radio health shows like Health talk, and Health Tuesday, just to mention a few hence making Please shed some light on your leadership journey as a the nation aware of the current health situations or Producer/Director. pandemics and how to manage and cope with them. No Journey in life is ever smooth, and mine is not different From the initial times of your career, what were the because I have risen in the ranks from being an intern, challenges you faced, and enlist us the professional sound boomer, scriptwriter, and actor then to finally being a hacks that helped you become the grand success that producer/ director. I am living proof that hard work, you are today? patience, and creativity really pay off. I started my career in an era where young people were What was the inspiration that prompted you to venture never heard because people believed in the older into the media niche? generation, I had to prove my worth before I was finally www.insightscare.com July | 2022 38

41. Interview with Insights Care I had to prove my worth before I was finally given a chance. I hacked all these by learning from others, accepting my flaws, taking corrections, training as much as I could, believing in myself, having a target, not giving up, being at your best even when everything is not working out for you. Peter Ogutu Producer/ Director Kenya Broadcasting Corporation given a chance, I hacked all these by learning from others, Yes, we are in a digital era, but when it comes to healthcare accepting my flaws, taking corrections, training as much as I am of the opinion that we keep it old school and go back I could, believing in myself, having a target, not giving up, to hospitals because nowadays people are dying slowly being at your best even when everything is not working out because they are busy googling their sickness and for you. diagnosing themselves and it's not good because you may end up treating something that's not even ailing you. Can you share how KBC provides leadership in transmitting objective, informative, educative content Please give us your valuable input about the future of and how it has made you ramp up your growth curve? the broadcasting niche for budding enthusiasts aspiring to venture into the media space. KBC is the oldest and first station in Kenya, It has seen nearly 85% of the professionals in the current media Broadcasting is going digital and online, so I would like to industry in Kenya, and it's the best media training ground in tell anyone who wants to join this Industry not to start this the country, I am the best because KBC took me in and journey thinking of how much money you are going to turned me inside out to be where I am today. make in this industry because it is not a walk in the park, you have to work hard, have the passion to do this, be open As a successful leader in the media space, what is your to changes because of the current trends. opinion on integrating technology with healthcare, which is currently grabbing the global spotlight? www.insightscare.com July | 2022 39