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BOLD Calibration: Arterial Spin Labeling (ASL) Measurement of CBF

BOLD Calibration: Arterial Spin Labeling (ASL) Measurement of CBF. Motivation. Cerebral Blood Flow (CBF) influences the BOLD Signal Provide a measure of vascular reactivity. ASL(Arterial Spin Labeling). Uses RF inversion to “tag” blood and measure where it goes. Proposed Work Plan.

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BOLD Calibration: Arterial Spin Labeling (ASL) Measurement of CBF

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  1. BOLD Calibration:Arterial Spin Labeling (ASL) Measurement of CBF

  2. Motivation • Cerebral Blood Flow (CBF) influences the BOLD Signal • Provide a measure of vascular reactivity

  3. ASL(Arterial Spin Labeling) • Uses RF inversion to “tag” blood and measure where it goes.

  4. Proposed Work Plan • Year 1: select, implement and test an ASL method • Year 2: Parametric assessment of ASL variables • Year 3: Develop algorithms for using baseline CBF in BOLD activation calculation • Year 4: Validate at sites • Year 5: Incorporate into the fBIRN protocol

  5. Cocaine • Observed brain hypoperfusion after 6 months of abstinence • May be to due to impaired cerebral vascular response • Measure CBF during a vascular challenge (breathhold) to assess vascular reactivity

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