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Priority of SARC studies for selected sub-types

Priority of SARC studies for selected sub-types. SARC 003 Gem/docetaxel Osteo/Ewings < 2 prior regimens Chondrosarcoma 0-X prior regimens SARC 006 AI/IE 1 st line. SARC 007 Perifosine < 3 prior regimens SARC009 Dasatinib 0-X prior regimens SARC 011 R1507 0-X prior regimens.

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Priority of SARC studies for selected sub-types

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  1. Priority of SARC studies for selected sub-types

  2. SARC 003 Gem/docetaxel Osteo/Ewings < 2 prior regimens Chondrosarcoma 0-X prior regimens SARC 006 AI/IE 1st line SARC 007 Perifosine <3 prior regimens SARC009 Dasatinib 0-X prior regimens SARC 011 R1507 0-X prior regimens Eligibility

  3. Chondrosarcoma • SARC 003: gemcitabine and docetaxel in bone sarcomas • SARC 007: perifosine in chemotherapy insensitive sarcomas (requires documented disease progression for participation) • SARC 009: dasatinib in advanced sarcomas (does not require documented disease progression for participation)

  4. Ewings • SARC 003: gemcitabine and docetaxel in bone sarcomas • SARC 011: IGF-1R for refractory/recurrent subtypes of sarcoma • SARC 009: dasatinib in advanced sarcomas

  5. Alveolar soft part sarcoma • SARC 007: perifosine in chemotherapy insensitive sarcomas • SARC 009: dasatinib in advanced sarcomas • SARC 011: IGF-1R for refractory/recurrent subtypes of sarcoma

  6. MPNST • SARC 006: chemotherapy in high-grade MPNST • SARC 009: dasatinib in advanced sarcomas

  7. Rhabdomyosarcoma • SARC 011: IGF-1R for refractory/recurrent subtypes of sarcoma • SARC 009: dasatinib in advanced sarcomas

  8. LiposarcomaExtraskeletal Myxoid Chondro • SARC 009: dasatinib in advanced sarcomas • SARC 011: IGF-1R for refractory/recurrent subtypes of sarcoma

  9. SARC Principles • Data trumps “BS” • Rhabdomyosarcoma • Ewings OTHERWISE • It’s not over till it’s over • 009 precedes 011 • 003 precedes 007 • In God we trust, everyone else pays cash OR • You vote with your feet

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