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Mini-Talk 2a The Sister Study

Mini-Talk 2a The Sister Study. Genetics, the environment, their interaction and breast cancer risk How will biomonitoring be used in this long-term study of sisters of women with breast cancer?

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Mini-Talk 2a The Sister Study

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  1. Mini-Talk 2a The Sister Study • Genetics, the environment, their interaction and breast cancer risk • How will biomonitoring be used in this long-term study of sisters of women with breast cancer? A special thanks to Dr. Dale Sandler, PI of Sister Study, for sharing her slides and graphics that were used for this mini-talk

  2. The Sister Studyhttp://www.sisterstudy.org Following 50,000 sisters of women diagnosed with breast cancer for 10 yrs Explore linkages between genetics, biology and the environment • Cancer and medical history • Diet and exercise • Personal care products use • Residential exposures / GIS • Workplace exposures

  3. The Sister Study-Creating a framework Create a framework to study current and future hypotheses • Be responsive to current public concerns • But, plan for the future • The hypotheses we may have in 5 to 10 years may be very different than our current ideas of what may affect breast cancer risk.

  4. B-D Alcohol Swab The Sister Study-Sample collection • Variety of human specimens • Blood • Whole blood, serum/plasma • Lymphocytes • Urine sample • Toenail clippings • House dust swipes

  5. The Sister Study-Possible future analyses • Hormones (estrogens, prolactin) • Growth factors (insulin-like-growth factor) • Dietary factors (vitamin metabolites) • Polymorphisms in variety of genes • DNA damage and repair

  6. The Sister Study-Possible future analyses • Environmental exposures • Metals (toenails and blood) • Phthalates and pesticides (urine) • Phenols, pesticides, PCBs, PAHs (blood / dust swipes) • Solvents, pesticides, phytoestrogens, melatonin metabolites, brominated and chlorinated chemicals (blood)

  7. The Sister Study-Working with CDC’s NCEH • NIEHS is working with CDC’s National Center for Environmental Health (NCEH) • The types of biomonitoring and genetic analysis possible in 5 to10 years will probably be much greater than what is currently available • Long-term storage of samples for future analysis

  8. The Sister Study-Storage of samples Twelve -20o C freezers Six -80o C freezers Each freezer holds 56,700 vials

  9. The Sister Study-Storage of samples 36 Liquid Nitrogen Tanks Each holds 275,184 “straw” samples

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