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Why Not Explore Trans-NIH Initiatives?

Why Not Explore Trans-NIH Initiatives? Dr. Alicia Dombroski, Director DEA, NIDCR Dr. Pamela McInnes, Director DER, NIDCR Dr. Kevin Hardwick, Chief, Research Training and Career Development Branch, NIDCR Dr. Renée Joskow, Dental Officer, NCRR

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Why Not Explore Trans-NIH Initiatives?

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  1. Why Not Explore Trans-NIH Initiatives?

  2. Dr. Alicia Dombroski, Director DEA, NIDCR Dr. Pamela McInnes, Director DER, NIDCR Dr. Kevin Hardwick, Chief, Research Training and Career Development Branch, NIDCR Dr. Renée Joskow, Dental Officer, NCRR Dr. Emily Harris, Chief Translational Genomics Research Branch, NIDCR

  3. Session Outline • American Recovery and Reinvestment Act • (ARRA) Opportunities • 2) NIH Office of the Director (OD) Programs • 3) Other Trans-NIH Programs • 4) New Principal Investigator/Early Stage • Investigator Policies

  4. American Recovery and Reinvestment Act (ARRA)- Impact of Economic Stimulus on NIH

  5. NIDCR is grateful to President Obama and Congress for the opportunity for NIDCR to play its part in improving the Nation’s health and economy

  6. American Recovery and Reinvestment Act (ARRA) Opportunities Overview Fund the best science while stimulating the economy • Recovery Act provides NIH with $10.4 billion for 2 years • $8.2 billion to support scientific research priorities • $7.4 billion transferred to Institutes and Centers, and the Common Fund (CF) • $800 million to OD, not including CF

  7. $1 billion for Construction, Repairs and Alterations • $300 million for Shared Instrumentation • $500 million for NIH buildings and facilities • $400 million for Comparative Effectiveness Research

  8. HHS.gov/Recovery Investment in Scientific Research and Facilities: Support for the construction of new research and educational facilities as well as groundbreaking scientific research that will improve the health of the nation.

  9. Funding Impact Stimulate the economy Create and preserve jobs Advance biomedical research

  10. Scientific Research Approach Stimulate and accelerate biomedical research with existing mechanisms Funding additional meritorious RO1s, R21s and R03s that have been peer reviewed and approved by IC Councils Administrative supplements to accelerate ongoing research Expand science with new programs Revisions to extant programs (“Competitive supplements”) New ARRA NIH-wide programs New ARRA IC-specific programs

  11. Opportunities Available

  12. New ARRA NIH-wide Programs Challenge Grants Grand Opportunities (“GO” Grants) Recruit new faculty to conduct research Provide summer jobs for high school / college students and teachers to work in science labs AREA (R15) Grants Supplements

  13. Challenge Grants At least $200M total to address priority avenues of research

  14. Challenge Grants Up to $500K total costs/year for up to two years 45 Topics identified by NIDCR 10 are high priority * April 27, 2009 receipt date CSR cluster review

  15. Grand Opportunity Grants Grand Opportunity (GO) Grants (at least $200M total): High impact Well defined Large scale

  16. “GO” Grants 8 Topics identified by NIDCR Testing Mechanisms of Action Hypotheses in Behavioral and/or Social Interventions Treatment of Tobacco and Drug Dependence in Multiple Dental Clinics Validation of Biomarkers of Oral Diseases or Salivary Biomarkers Detection of Oral Premalignant and Malignant Lesions Genome-wide studies in Craniofacial, Dental and Oral Conditions: Data Generation, Analysis and Integration Multidisciplinary Approaches to Craniofacial Regeneration and Preclinical Testing Oral Cancer Genome Analysis Human Pain Phenotypes and Pain Circuitry April 27, 2009 letter of intent receipt date May 27, 2009 receipt date IC peer review

  17. Administrative Supplements NIDCR Strategic Plan 2009-2013 List of interests on NIDCR website Priority to requests under $100,000 Receipt date June 1, 2009 Eligible: All mechanisms except Fs, T32, L30/40, R13/U13, R25 Up to $12M to the ARRA supplement program – 65% to the Collaborative Sciences Program

  18. Administrative Supplements for Collaborative Science Enable NIDCR-funded investigators to form new collaborations to promote the discovery of novel insights required to achieve significant research advances. Must be within scope of the approved aims of the parent award. Existing collaborations not eligible. Up to $120,000 total direct annual costs for the first collaboration. An additional $60,000 for a second collaborating group. Term is up to duration of the grant. Eligible: R01, R15, R37, P01, P50, R42, R44, U01, U19, U54

  19. Competing Revisions To support a significant expansion of the scope of approved and funded research. Requests must be consistent with the goals of the Recovery Act. Up to $10M to the Competing Revision program. Eligible: All mechanisms except Fs, Ks, T32, L30/40, R13/U13, R25

  20. Summer Jobs in Research for Students and Teachers Engage students and educators in research Encourage students to pursue research careers Provide summer internships at NIH-funded laboratories for science teachers

  21. Notice OD-09-060 To further science of parent research grant High school and undergrad students High school, community college teachers, faculty from non-research intensive universities Dental students allowed NOT substitute for T35/T32 summer training program No post-docs ARRA Summer Student Supplements

  22. New Faculty Core Centers for Enhancing Research Capacity in U.S. Academic Institutions Newly trained scientists Start-up packages Pilot research projects

  23. RFA OD-09-005 Develop a Center for conducting research in a specific scientific topic or problem Recruit and hire new tenure-track research faculty to develop and conduct this research “awards will be directed towards hiring investigators and providing appropriate start-up research resources (e.g., research salary, equipment, and supplies for initiating their research) that will help strengthen or expand the scientific capacity of the Biomedical Research Core Center. ” Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers (P30)

  24. Core Centerdefined scientific/research purpose Salary (75% protected research effort) Start-up package Funds for research resources New independent tenure-track faculty hired and appointed to the Core Center to develop and conduct research projects which fit the purpose/mission of the Center

  25. $500,000 per year for two years (direct costs) Salary Start-up costs, including supplies, equipment and support for technical personnel Research costs to conduct projects within scientific mission of Center Joint appointment, with at least 75% protected research time Priority given to applications offering commitment beyond the 2-year duration of the grant NIH P30: Supporting New Faculty Development to Enhance Research Productivity through Biomedical Research Core Centers

  26. New faculty hired through P30 Appointed to independent tenure-track (or equivalent) research position at the Assistant Professor level with at least 75% protected research time New to the faculty and not previously held a tenure-track research appointment Record of research training and career development in a research area relevant to the primary mission of the Core Center NIH P30: Supporting New Faculty Development to Enhance Research Productivity through Biomedical Research Core Centers

  27. New faculty hired through P30 Receive joint appointment(s) with other academic unit(s) at the institution, allowing access to University-wide research resources and core facilities, and to serve as mentors for graduate programs affiliated with other academic unit(s) Receive a start-up package, including supplies, equipment and support for technical personnel NIH P30: Supporting New Faculty Development to Enhance Research Productivity through Biomedical Research Core Centers

  28. NCRR Initiatives Renée W. Joskow, D.D.S., M.P.H.,FAGDCAPT, U.S. Public Health ServiceDental Officer (Research)Division for Clinical Research ResourcesNational Center for Research Resources

  29. National Center for Research Resources NCRR will administer more than $1.6 billion in federal grants in the following areas:$1 billion for construction, repair and renovation of research facilities $300 million for shared instrumentation and other capital research equipment Up to $310 million in support of biomedical research priorities

  30. American Recovery and Reinvestment Act (ARRA or Recovery Act) of 2009 Four related Funding Opportunity Announcements (FOAs) have been released in response to the Recovery Act Two for instrumentation PAR-09-028 Shared Instrumentation (SIG Program) PAR-09-118 High End Instrumentation (HEI Program) Two that allow alterations and repairs RFA-RR-09-008 (supports construction, renovation and repair improvement projects; C06 mechanism) RFA-RR-09-007 (supports core facilities improvement projects; G20 mechanism)

  31. Shared and High-End Instrumentation Program (S10): Overview • Unique and critical NIH mechanisms • Provide funding in cost-range from $100k to $8.0M • SIG Program (funding range $100k to $500k)- PAR-09-028 • HEI Program (funding range $600k to $8.0M)- PAR-09-118 • Equipment which is too costly to obtain with regular NIH research grants • Highly cost-effective mechanisms • Instruments placed in core facilities • Shared by an average of 8-10 grantees

  32. High End Instrumentation (S10) • Program Announcement: PAR-09-118 • Notice update: NOT-RR-09-008 • Single major item of equipment • $600k – $8.0 Million • Deadline May 6, 2009 • One Year • No limit on number of applications • 3 or more NIH-funded users • Approximately $160 Million in FY2010 • Two levels of review

  33. Extramural Research Facilities Improvement Program (C06) • To construct, renovate or repair biomedical or behavioral research extramural facilities. • Provides $2 – 15M for direct costs that improve non-federal basic and clinical research support • No more than 3 applications per institution • Project period not to exceed 5 years

  34. Extramural Research Facilities (C06) What are the application deadlines? The receipt date of May 6, 2009, is for projects between $2 million and $5 million. The receipt date of June 17, 2009, is for projects between $10 million and $15 million. The receipt date of July 17, 2009, is for projects between $5 million and $10 million.

  35. Core Facility Renovation, Repair and Improvement (G20) • To renovate or repair extramural core facilities to support biomedical and/or behavioral research, funded by the U.S. Public Health Service (PHS) • A core facility is defined as a centralized shared resource that provides access to instruments or technologies or services, as well as expert consultation to NIH-funded investigators. • Deadline for applications is Sept. 17, 2009 • Budgets between $1 million and $10 million may be requested • No more than 2 applications per institution

  36. Comparison of G20 and C06 RFAs *An institution is defined as an organization with a separate IPF code identifier.

  37. Comparison of G20 and C06 RFAs (II) Item RFA-RR-09-007 (Core facilities) RFA-RR-09-008 (Construction, etc.) New construction, and completion of shell space No Yes Receipt date(s) September 17, 2009 May 6, 2009 ($2 – 5 M) June 17, 2009 ($10 – 15 M) July 17, 2009 ($5 – 10 M) Award start dates July 2010 December 2009 & April 2010 Green technology & design approaches Creation/retention of American jobs Yes Yes Yes Yes

  38. ARRA/Recovery Act Construction Programs • C06/G20 Applicant Help Videocast http://videocast.nih.gov/ram/arra032309.ram • ARRA RFA and FAQ URLs • CO6 • RFA: http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-09-008.html • FAQs: www.ncrr.nih.gov/C06_Q&A.asp • G20 • RFA: http://grants.nih.gov/grants/guide/rfa-files/RFA-RR-09-007.html • FAQs: www.ncrr.nih.gov/G20_Q&A.asp • NIH Enhancing Peer Review Web site • http://enhancing-peer-review.nih.gov/

  39. NCRR Challenge Grants • Bioethics • 02-RR-101* Recontact Issues in Genotype and Genome-Wide Association Studies • 02-OD(OSP)-103* Ethical Issues Associated with Electronic Sharing of Health Information • Comparative Effectiveness Research • 05-RR-101* Build CER Capacity Through Education • 05-RR-102* Support Pilot CER Projects in Community Settings • Enabling Technologies • 06-RR-101* Virtual environments for Multidisciplinary and Translational Research • 06-RR-102* Infrastructure for Biomedical Knowledge Discovery

  40. NCRR Challenge Grants (II) • Information Technology for Utilizing Health Care Data Research • 10-RR-101* Information Technology Demonstration Projects Facilitating Secondary Use of Healthcare Data for Research • Translational Science • 15-RR-101* Applied Translational Technology Development • 15-RR-102 Develop a Nationwide Electronic Material Transfer Agreement (MTA) Database System The application due date is April 27, 2009

  41. Competitive Revision Applications Investigators and U.S. institutions and organizations with active NIH funded investigator-initiated awards (R01, R33, R37, R21, U01) reviewed by the Center for Scientific Review (CSR) to leverage the resources, expertise, and infrastructure of the NCRR centers and center-like programs through significant expansion of the scope or research protocol of approved and funded projects. Deadlines are: April 21, 2009 or July 10, 2009

  42. Centers and Center-like Programs Animal and Biological Material Resources Biomedical Technology Research Centers Clinical and Translational Science Awards General Clinical Research Centers Institutional Development Award National Primate Research Centers Research Centers in Minority Institutions Science Education Partnership Awards

  43. Administrative Supplements for NCRR Awards Investigators and U.S. institutions or organizations with active NIH research grants may request administrative supplements for the purpose of accelerating the tempo of scientific research on active grants. The NCRR administrative supplement application due date is May 18, 2009 Can apply for up to two years of support

  44. Administrative Supplement Priorities Administrative Supplements to Advance Translational (T1 & T2) Research Administrative Supplements for the CTSA Consortium Strategic Goals Administrative Supplements for Enhancing NCRR Pilot Project Mechanism Administrative Supplements for Collaborative Community Engagement Research Administrative Supplements for Research Workforce Development and Dissemination Administrative Supplements for Science Education and Dissemination

  45. Estimated Proportions of NCRR ARRA Funding for Administrative Supplements

  46. NCRR Funding Opportunities http://www.ncrr.nih.gov/research_funding/funding_opportunities/

  47. Questions? Renée W. Joskow, D.D.S., M.P.H., FAGDCAPT, U.S. Public Health ServiceDental Officer (Research)Division for Clinical Research ResourcesNational Center for Research Resources Joskowr@mail.nih.gov301-435-0961

  48. NIH and ARRA Stimulating the economy Creating and preserving jobs Advancing biomedical research Improving people’s health

  49. NIH Office of the Director Programs: • “The NIH Common Fund” • Codified into law by 2006 NIH Reform Act • Purpose: to support cross-cutting, trans-NIH programs that require participation by at least two NIH Institutes or Centers • Typically involves initiatives (RFAs and policy changes) developed by multiple NIH Institutes or Centers • Centerpiece is NIH Roadmap for Medical Research

  50. Main Goals of the NIH Roadmap: • Foster high-risk/high-reward research • Enable the development of transformative tools and methodologies • Fill fundamental knowledge gaps • Change academic culture to foster collaboration

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