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Overview : Innate Immune Response

Overview : Innate Immune Response. Receptors Detect Infection. Toll-like Receptors. Toll-like Receptors. Signal Transduction. Signal Transduction. Ubiquity of Innate Immunity. Review: Cells of the Immune System. Leukocytes – White blood cells

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Overview : Innate Immune Response

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  1. Overview: Innate Immune Response

  2. Receptors Detect Infection

  3. Toll-like Receptors

  4. Toll-like Receptors

  5. Signal Transduction

  6. Signal Transduction

  7. Ubiquity of Innate Immunity

  8. Review: Cells of the Immune System Leukocytes– White blood cells Myelocytes–macrophage, neutrophil, eosinophil,basophil Lymphocytes – B, T and NK cells From Larsson and Karlsson (2005)

  9. Review: Myelocytes •Macrophages – phagocytes, antigen presenting cells (APCs), specialized cells different organs, secrete cytokines, produce complement proteins, can produce ROS/RNS. •Neutrophils – phagoctyes, can produce ROS/RNS, secrete antimicrobial peptides, 1st cell type to migrate from blood to infections, main targets are bacteria and fungi •Eosinophils– phagocyte, targets parasites •Basophils – secrete cytokines, involved in allergic response

  10. Review: Lymphocytes • B cells – naïve B cells: contain antigen binding receptor (or membrane bound antibody), once activated – memory cells: provides memory of antigen/antibody interaction; plasma cells: secrete soluble antibody

  11. Review: Lymphocytes • T cells - contain antigen binding receptor (TCR) TH cells: secretes cytokines that activate B cells, TC cells, macrophages and others. TC cells: eliminates altered/damaged self cells (particularly those infected by viruses), fights tumors cells, secrete cytotoxins. Tregcells: helps suppress immune response, plays a role in tolerance. T reg cell

  12. Review: Cells of the Immune System •Natural killer cells – distinct from T and B cells due to lack of an antigen binding receptor, similar in function to TC cells, macrophage activation, defense against viruses, fight tumor formation, secrete cytotoxins.

  13. Review: Cells of the Immune System Derived from both lymphoid and myeloid precursors •Dendritic cells – phagoctyes, antigen presenting cells (APCs), can produce ROS, secrete proinflammatory cytokines, secrete antimicrobial peptides.

  14. Review: Organs of the Immune System Primaryand secondary lymphoid organs: 1°- maturation of lymphocytes 2°- sites where mature lymphocytes interact with antigen. Level of organization: collection of cells vs. lymphoid follicle

  15. Review: Innate and adaptive immunity

  16. Review: Innate Immune Response

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