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Figure 1

Man 6P receptors. Man6P. Man6P. Asn70. Asn199. pro 4 K. NH2. COOH. 14 K. 34 K. Asp. Asp. 1. - 44. 348. 33. 231. catalytic site. Figure 1. Tumor micro-environment. Activation at acidic pH. Secretion. Endocytosis. 52K. 52K. 52K. 52K. 48K. M6P receptors

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Figure 1

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  1. Man 6P receptors Man6P Man6P Asn70 Asn199 pro 4 K NH2 COOH 14 K 34 K Asp Asp 1 -44 348 33 231 catalytic site Figure 1

  2. Tumor micro-environment Activation at acidic pH Secretion Endocytosis 52K 52K 52K 52K 48K M6P receptors and other proteins Endosomes Lysosomes Degradation Golgi Apoptosis ER 34K 34K 14K 14K Cytosolic cath-D Transcription ? Nucleus Figure 2

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