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Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering

Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering. Aim 1. Construct synthetic vascular networks with thermally reversible polymers and microfluidics. End goal: formed endothelial tube. Top . Vascular-mimetic microfluidic channel .

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Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering

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  1. Engineered 3D Vascular Networks: Enabling technology for Vital Organ Engineering • Aim 1 • Construct synthetic vascular networks with thermally reversible polymers and microfluidics End goal: formed endothelial tube Top Vascular-mimetic microfluidic channel Mold thermally reversible polymer containing endothelial cells culture Cross- section 200μm • Aim 2 • Assemble alternating vascular and hepatocyte layers towards 3D synthetic vascularized liver construct Complex liver microvasculature Hepatocytes Cross-section Engineered vascular networks (Mary Beth Wilson, Dowd Fellowship 2010)

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