310 likes | 1.02k Views
Craniofacial anomalies. HuGENet NETWORK OF NETWORKS WORKSHOP October 2005. Julian Little Canada Research Chair in Human Genome Epidemiology Department of Epidemiology & Community Medicine University of Ottawa. Origins. WHO Human Genetics Programme, 2000 Financial support from NIDCR (US)
E N D
Craniofacial anomalies HuGENet NETWORK OF NETWORKS WORKSHOP October 2005 Julian Little Canada Research Chair in Human Genome Epidemiology Department of Epidemiology & Community Medicine University of Ottawa
Origins • WHO Human Genetics Programme, 2000 • Financial support from NIDCR (US) • Five-year project designed to take forward international strategy on craniofacial anomalies
Objectives of WHO project • to develop an international network for consensus building, planning and development for international collaborative biomedical, epidemiological and behavioural studies in the core areas of craniofacial anomalies research • to create a directory of research resources in craniofacial anomalies. • to create the International Database on Craniofacial Anomalies (CFA)
Core areas • genetic basis of CFA • gene-environment interactions involved in CFA • prevention of CFA • optimal treatment of CFA
Consensus meetings • Nov 2000 – concurrent workshops on (1) genetic basis (2) g-e interaction (3) treatment • May 2001 – prevention • Dec 2001 – global registry
2002 2003
Consensus meetings • Nov 2000 – concurrent workshops on (1) genetic basis (2) g-e interaction (3) treatment • May 2001 – prevention • Dec 2001 – global registry • Dec 2004 – progress and future strategies ________
Reported investigations on gene-environment interaction in aetiology of oral clefts
Gene-environment interaction and oral clefts: data and sample collections
Identifying teams • List developed from WHO reports and literature searches • Asked those who attended WHO meetings (1) about concept (2) to review list and extend if possible • Contact additional teams identified
Teams • with established data and sample collections • with ongoing data and sample collections • planning to establish data and sample collections
N of cases from cc studies; trios; samples; (studies)………
Co-ordination • Ottawa • Dundee (Peter Mossey) • Iowa (Jeff Murray)
Other issues • Different designs • Samples • Governance • Further analyses possible? • Outside country? • Elsewhere within country? • Only in own centre?