Echinococcosis ( 棘球蚴病）

1. Echinococcosis(棘球蚴病） 组员：冯顺意 黄敬贤 龙佳

2. Echinococcosis(棘球蚴病) Echinococcus granulosus（细粒棘球绦虫） Hydatid(棘球蚴) It is a zoonotic disease（动物传染病） affecting mainly various species of livestock and humans. It causes great economic losses in animal husbandry

3. Morphology Echinococcus granulosus( 细粒棘球绦虫) Hydatid(棘球蚴)

4. Echinococcus granulosus(细粒棘球绦虫) Definitive host: dog、wolf、fox Site: small intestine

5. Hydatid (棘球蚴) • Intermediate host:cattle、 goat and sheep、pig、horse、camel，wildlife and humans • Site: liver、lung

6. Life cycle

7. Epidemiology • Cosmopolitic distribution（世界性分布） • High infection rate in sheep（绵羊感染率最高） • E. granulosus（细粒棘球绦虫）and E. multilocularis（多房棘球绦虫）can infect human • Strong resistance of egg

8. Continued growth Sympotoms and Lesions Harm the human body and animal body mainly by mechanical damage Hydatid Oppression tissues and organs around it Tissue 、cell atrophy（萎缩）, necrosis（坏死）, Hydatid fluid leakage（棘球蚴液渗出） Toxicity or allergic reaction

9. 腹部包虫病患者

11. Section of sheep liver showing fertile Hydatid cysts

14. DIAGNOSIS • Clinical symptoms（临床症状）：a slow-growing tumor accompanied by eosinophilia(嗜酸性粒细胞增多). • Intradermal test(皮试) with Hydatid fluid. • Pulmonary cysts（肺囊肿） and calcified cysts（钙化的包囊） can be visualized using x-rays(X光透视). • Immunological methods: IHA, ELISA, ABC-ELISA (亲和素生物素酶免疫吸附试验), E-CIEP (酶标记对流免疫电泳), etc

15. TREATMENT • Dogs: Can use praziquantel（吡喹酮）. After treatment it is advisable to confine dogs for 48 hours to facilitate the collection and disposal of infected faeces. • Sheep, yak and cattle: Can use albendazole (丙硫咪唑): 90 mg∕kg（连服2次） ,and praziquantel (吡喹酮):25~30 mg∕kg. • Humans: Surgical excision（外科切除） of hydatid cysts although there is a risk of re-development of released daughter cysts（子囊）. Can use mebendazole（甲苯咪唑）, albendazole（丙硫咪唑） and praziquantel（吡喹酮）.

16. Prevention • Ban to feed dog with infected organs • Deworming of dogs • Maintain the barn, feed, water sanitation, prevention of canine fecal contamination • For us ,pay attention to personal hygiene（个人卫生） • Avoiding contact with infected dogs

17. 谢 谢！