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RADIOPHARMACOLOGY. Radio. pharmaceutical. Ideal Radiopharmaceutical. Easily available. High Target vs. Non-Target ratio. . . . Particle Emission. Electron capture. Isomeric conversion. Decay Method. >30keV. <300keV. Short Effective half-life. l e = l p + l b.
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Radio pharmaceutical
Ideal Radiopharmaceutical Easily available High Target vs. Non-Target ratio Particle Emission Electron capture Isomeric conversion Decay Method >30keV <300keV Short Effective half-life le = lp + lb b = 0.693 / Tb 1 = 1 + 1 . Te Tp Tb Tp x Tb Te = Tp + Tb
Passive Diffusion DTPA - Brain imaging 133Xe
Ion Exchange MDP
Phagocytosis Sulfur Colloid
Active Transport 131I 201Tl
Cell Sequestration Heat Damaged 99Tc-RBCs
Metabolism 18F 18FDG
Receptor Binding MIBG 11C Dopamine
Compartmental Localization 99Tc – Ultratag / PYP
Antigen – Antibody Complex Tumor Imaging Therapy
Chemotaxis Tagged WBC
Factors influencing design of new drugs
Important factors in labeling Efficiency Stability Denaturation or Alteration Isotope Effect Carrier-Free or No-Carrier-Added (NCA) Storage and Shelf Life Specific Activity Radiolysis Purification and Analysis
Adverse Effects Iatrogenic Alteration
Anaphylactic Reaction HAMA Allergic Reaction MAA Sensitivity I-131