mesopeels

1. mesopeels

2. Range of chemical peelings for skin renovation and rejuvenation

3. mesopeel Index Introduction Mesopeelhidroxiacids Mesopeel combined Mesopeeltrichloroacetic Application protocol

4. mesopeel introduction line of chemical peelings for the treatment and correction of different cutaneous disorders. • Based on the used dermopeeling, we can achieve: • Different degrees of exfoliation, and therefore superficial depigmentation and scarring attenuation. • Stimulation and reorganization of the collagen and elastin fibres, improving physiological and mechanical qualities of the skin. • Increased fibroblast activity , that synthetises different macromoléculas on the extracelular matrix and more hydration. • Correct sebaceous secretion and a decrease on the number of imperfections.

5. mesopeel introduction + Acid in men + Acid in dryskins Complete renovation in 28 days pH 4.2 – 5.6 (sweat and sebum) Epidermis Elastin Glycosaminoglycan Collagen pH 6 – 7 (vessels and fibres) Dermis

6. mesopeel Mechanism of action A chemical peeling acts on the skin though three mechanisms: TISSUE DESTRUCTION INFLAMMATION MEDIATORS ACTIVATION FORMATION OF NEW COLAGEN

7. mesopeel Mesopeel hydroxide acids

8. mesopeel Classification

9. mesopeel Mesopeel hydroxide acids mesopeel hydroxide acids: • They are organic acids that contain an hydroxide group. • Various concentrations (weight and volume). BHA´s AHA´s • Salicylic Acid • Glycolic Acid • Mandelic Acid • Lactic Acid

10. mesopeel mesopeel hydroxide acids Hydroxide acids glycolic_peel AG lactic_peel AL mandelic_peel AM salicylic_peel AS

11. mesopeel mesopeel hydroxide acids • Hydroxide acids are organic acids that contain an hydroxide group. • Alpha-hydroxide acids (AHA’s) have the hydroxide group next to carboxyl, from which it derives: • Glycolic Acid • Mandelic Acid • Lactic Acid • Beta-hydroxide acids (BHA’s) have it further in the molecule, from which it derives: • Salicylic Acid • General characteristics of the mesopeels hydroxide acids are the following: • Various concentrations (weight and volume) • pH 1,8 • Cosmetic form : fluid transparent gel without preservatives • Presentation: 50ml container + measuring glass + neutralizer

12. mesopeel mesopeel hydroxide acids glycolic_peel AG • General characteristics: • Formulated for intensive skin care for Photo-aging, cutaneous stains, imperfections in skins with tendency to acne or other causes. • Stimulate the cellular regeneration and the synthesis of collagen. • Mechanism of action: • Destroys the protein bindings between the corneocytes. • Stimulates the production of collagen in the fibroblasts. • Indication: • Ideal for all types of skins. • Reduction of wrinkles depth. • Diminishes post acne scarring. Concentractions: 20%, 35%, 50%* and 70%*. (*)Concentrations of 50% and 70% are of exclusive medical use

13. mesopeel mesopeel hydroxide acid lactic_peel AL • General characteristics: • Indicated for mild or moderated photo-aged skins • Soften contours, improves the texture, tone and aspect of the skin in general. • Mechanism of action: • Destroys the protein bindings between the corneocytes causing the to detach. • Stimulates the production of GAG’s in the dermis and increases its hydration. • It is less aggressive than Glycolic Acid for the skin. • Indication: • Ideal for dry and sensitive skins. • Stretch marks. • Actinic damage. Concentrations: 30%, 40%* and 50%*. (*) the concentration of 50% is for exclusive medical use.

14. mesopeel mesopeel hydroxide acids mandelic_peel AM • General characteristics: • Indicated for fight imperfections of skins with tendency to acne that can also combine Photo-ageing and/or hyperpigmentation. • Produce a mild and progressive exfoliation . • Antiseptic and depigmentation effects. • Mechanism of action: concentrations: 30%, 40% and 50%*. (*)concentration of 50% is of eclusive medical use • Breaks the unions between corneocytes of the stratum corneum, as well as the cellules of the epidermis and the dermis. • Stimulate the synthesis of collagen and proteoglycans. • Induce a process of cutaneous rejuvenation. • Indication: • Ideal for thick, oily and seborreic skins. • treatment of hyperchromies. • Photo-aging / Dilated pores.

15. mesopeel mesopeel hydroxide acids salicylic_peel AL • General characteristics: • Formulated to reduce or eliminate imperfections in skins with tendency to acne, photo-aging alterations and wrinkles. • Controls the proliferation of “propionilbacterium acnes”. • Mechanism of action: • Liposoluble substance that eliminates intercellular lipids. • It does not have inflammatory action, and therefore it is safe in skins predisposed to PIH (Post-inflammatory Hyperpigmentation). • Indication: • Hyperkeratosis skins . • Oily / proacneic skins. • Acneic skins. • Ideal as deep hygiene treatment . Concentrations: 10%, 20% and 30%*. (*) Theconcentration of 30% is of exclusive medical use

16. mesopeel mesopeel hydroxide acids MAXIUM RECOMMENDED EXPOSITION TIMES * The maximum exposition time will always be subject to the professional criteria.

17. mesopeel Combined mesopeel

18. mesopeel Combined mesopeel

19. Combined melanostop_peel mesopeel_azelan mesopeel_jessner modified

20. Combined melanostop_peel mesopeel_azelan mesopeel_jessner modified piruvex_peel

21. mesopeel Combined mesopeel melanostop_peel • General characteristics: • Its effect is based on the synergic action of the three active ingredients that work jointly. • Composition: • Azelaic Acid 20%: Essentially metabolic activity. Antioxidant properties. • Resorcinol 10%: Whitening effect. • Fitic Acid 6%: depigmentation. • Mechanism of action: • Inhibition of formation of abnormal melanic pigmentations. • Renovation of the epidermis. • Whitening effect • Indications: • Treatment of superficial melasma. • epidermal solar lentigo. • Body hypercromies (armpits, knees, groin, etc…)

22. mesopeel Coadjuvant products melanogelantispotcream melanogeltouch // puntual depigmentationtreatment Depigmentationcream post-treatment post-treatment Applymorning and night Applymorning and night puntual depigmentationtreatment . Depigmentationcreamforalltypes of skins.

23. mesopeel Combined mesopeels mesopeel_azelan • General characteristics : • Especially indicated in oily skins or with acneic tendency. • Treatment of acne in all its different manifestations. • composition: • Azelaic Acid 20%: Activity essentially metabolic. Antioxidant properties. • Salicylic Acid 20%: Epidermical exfoliation. Antiseborrheic action. • Indications: • Oily proacneic skins. • Mild or moderate acne. • Comedonal skins.

24. mesopeel Productoscoadjuvants purifyingcleanser // purifyingfacemask // mask facial exfoliant Facial gel continousmaintenance continousmaintenance applicationmorning and night applicationmorning and night Descaling and purifying facial mask. Cleansing facial gel foroily and pro-acneicskins. cosmelan active system spottreatment purifyingcream // Maintenancecream post-treatment post-treatment applicationmorning and night Puntual application Easesthe superficial peeling and preventsporeobstruction. Sebumregulation puntual treatment

25. mesopeel Combined mesopeel mesopeel_jessner modified • General characteristics: • Ideal for faded skins care , with signs of chronologic aging , superficial scars and epidermal hyperpigmentations. • Composition: • Salicylic Acid 14%: Keratolytical exfoliating and comedolytic effect. • Lactic Acid 14%: Gives tautness and hydration to the skin. Activates the formation of collagen and elastin. • Citric Acid 8%: Lesser keratolytical action due to its heavier molecular weight. Similar properties to Lactic Acid. • Indications: • Photoaging. • Antiaging treatments. • Post-acne scarring.

26. mesopeel Coadjuvant products post-treatment post-treatment continousmaintenance continousmaintenance Cosmeceutical line withhighconcentrations of Vitamin C. Cosmeceutical line withhighconcentrations of marine collagen.

27. mesopeel Combined mesopeel piruvex_peel • General characteristics: • Specially indicated to tackle photo-aging, thin and deep wrinkles. • Useful in acne and thin seborrheic keratosis. • Increases the tone, luminosity and softness. • Composition: • Pyruvic Acid 40%: Tackles chrono- and photo-aging. • Lactic Acid 10%: Stimulates new collagen, elastic fibres and glycoproteins production. • Indication: • Chronologic aging. • Photo-ageing. • Deep wrinkles. • Post-acne scarring. • Seborrheic and actinic keratosis.

28. mesopeel Productoscoadjuvants post-treatment post-treatment continousmaintenance continousmaintenance global antiagetreatmentthatincludes [meso]recoverycomplex. Cosmeceutical line withhighconcentrations of vegetal stemcells.

29. mesopeel Exposition time MAXIMUM RECOMMENDED EXPOSITION TIME * The maximum time of exposition will be subject to professional opinion.

30. mesopeel mesopeeltrichloroacetic

31. Trichloroacetics mesopeel_TCAsoft mesopeel_TCA

32. mesopeel mesopeeltricloroacético mesopeel_TCA and mesopeel_TCAsoft • General characteristics: • Trichloroacetic Acid is derived from Acetic Acid through by chloration of three hydrogenate ions. • Treats superficial and mid lesions. • Superficial lesions: superficial hyperchromies, comedonal acne , thin wrinkles . • Mid lesions: Acne damage reversion, actinic keratosis, wrinkles, dyschromy. • Mechanism of actuación: • Actsbyfloculationpfskinproteins. • Produce theprecipitation of proteinsbyhydrofobicinteraction. hidrofóbica. • Indication: • Treatment of photo-aging, wrinkles, actinic and seborrheickeratosis, pigmentarydischromies, acne and acnescars; and lack of facial luminosity.

33. mesopeel Treatment protocol PHASE PRIOR TO TREATMENT: Complete a clinical record (anamnesis) Alltherelevantdata will be collectedsuch as , habits, personal ortechnical (skintype, lesiontypes, associatedproblems) and anyfactorsrelatedtothedisorder. Personalized diagnosis In ordertoadapttheapplicationprotocolbasedontheneeds of eachpatient Fillouttheinformedconsentform Involvingthepatientonthetreatmentprocess, and also at thesame time invite themtocontinuewiththe home treatment (fundamental protocol) Photographicregister Guaranteingan objetive assessment of theevolution of results Control visits Itisimportanttocarryout control visitswithanadaptedperiodicitybasedonthe particular needs of each case.

34. mesopeel Treatment protocol CONSIDERATIONS WHEN WE CARRY OUT A CHEMICAL PEELING • Treatment with retinoid (6 month wash out period). • Active herpes lesions. • Pregnancy. • History of keloids or hypertrophic scars. • Solar allergies or photo-sensitization. • Hypersensitivity reaction to peeling. • Radiotherapy treatment. • Previous surgery in the area where the peeling it will applied.

35. mesopeel Treatment protocol Mesopeelapplicationprotocol Phase 1: preparation Removemake up and tone up withhydramilkcleanserand hydratonic. Phase 2: degrease Applyprofessional degreasing lotionwith a gauzeand rubbing.

36. mesopeel Treatment protocol Mesopeel application protocol Phase 3: protect Protect with mesolips protector areas that due to their sensitivity must not be in contact with the peeling. Phase 4: treat Apply with a brush or gauze the selected peeling according the type of skin and estetopathy that will be treated. Control the exposition time.

37. mesopeel Treatment protocol Mesopeel application protocol Phase 5: remove and neutralise Remove with abundant water and spray the area treated with post-peel neutralizing spray. Phase 6: enhacing the result Apply the mask post-peel crystal fibre mask or anti-stress face mask and leave in exposition for 20 minutes.

38. mesopeel Treatment protocol Mesopeelapplicationprotocol Phase 7: complete and protect Afterremovingthemaskapplypost-procedurefastskinrepaircream. Applymoisturisingsunprotection.

39. mesopeel Treatment protocol CHANGES IN THE SKIN DURING THE TREATMENT This sensation is relieved through the repeated application of products that encourage reepitelization and hydration. Sensation of tightness PEELING It is an expected evolution after carrying out an Acid based treatment. Frost The frosty areas must be moisturised repeatedly on subsequent days. Burning Typical treatment manifestation; Cool air may relieve this sensation. According to skin sensitivity, erythema may appear, being a temporary manifestation. Erythema

40. mesopeel Treatment protocol APPLICATION OF CHEMICAL PEELINGS| CYCLES OF TREATMENT Beforeanother more specifictype of treatment , itisadvisableto prepare theskinwiththe peeling application . Forthisreason, itisadvisabletocarryout a session 10 daysbeforeapplyingtreatmentwithmesohyal, treatment antiaging, photogensystem, tmtsystem, amongstothers. Peeling as previoustreatment Peeling as como specifictreatment When an estetopathy is treated with peelings, cycles of 6 to 8 sessions are recommended. Peeling as maintenance It is advisable to carry out a peeling in every season of the year, once every 3 months approximately.

41. mesopeel Results | Clinical cases After Before

42. mesopeel Results | Clinical cases After Before

43. mesopeel Results | Clinical cases Before After Firstsession: salicylic_peel 10 % + 3 sessionspeeling combined

44. mesopeel Results | Clinical cases Before After 6 sessions mesopeel glycolic_peel AG 20% and 35%

45. mesopeel Results | Clinical cases

46. mesopeel mesoestetic peelings advantages THEY CAN BE USED IN ANY SEASON OF THE YEAR APPLICABLES TO ANY PHOTOTYPE IDEAL FOR BOTH FACIAL AND BODY TREATMENTS FAST, SIMPLE AND HARMLESS APPLICATION VISIBLE RESULTS FROM THE FIRST APPLICATION THEY NO DOT REQUIRE RECOVERY PERIOD

47. mesopeel Peelings registered at AgenciaEspañola de Medicamentos y ProductosSanitarios mesoestetic glycolic_peelAG 20% / 318-PE mesoestetic glycolic_peelAG 35% / 316-PE mesoestetic glycolic_peelAG 50% / 326-PE mesoestetic glycolic_peelAG 70% / 325-PE mesoestetic lactic_peel AL 30% / 315-PE mesoestetic lactic_peel AL 40% / 322-PE mesoesteticlactic_peel AL 50% / 321-PE

48. mesopeel Peelings registered at AgenciaEspañola de Medicamentos y ProductosSanitarios mesoestetic mandelic_peel AM 30% / 317-PE mesoestetic mandelic_peel AM 40% / 320-PE mesoestetic mandelic_peel AM 50% / 319-PE mesoestetic salicylic_peel AS 10% / 314-PE mesoestetic salicylic_peel AS 20% / 324-PE mesoestetic salicylic_peel AS 30% / 323-PE

49. mesopeel Peelings registered at Agencia Española de Medicamentos y Productos Sanitarios mesoestetic mesopeel_TCA / 364-PE mesoestetic mesopeel_TCA Soft / 365-PE mesoestetic melanostop_peel / 370-PE mesoestetic mesopeel_azelan / 368-PE mesoestetic piruvex_peel / 366-PE

50. mesopeel FAQ’s – mesopeel • How does a chemical peeling work? • Besides of smoothing the skin, it unleashes series physiological reactions and increases cutaneous permeability, stimulating the synthesis of collagen through a controlled aggression of the skin (decrease of pH). • 2. What performance can I get in sessionswith a bottle of peelings? • Each bottle of peeling contains enough product for approximately 10 facial applications (5 ml. per session). • Hoy do I ken te peeling once oponed? • It can be perfectly kept at room temperature, closing it properly to avoid that it vaporises and the gel base solidifies. • In case that it adopts a very viscose consistence, it can be rinsed with abundant hot water and shake it well until it reaches gain the right texture to apply it.