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The balancing act. Redox poise and signalling The Drummond lecture

The balancing act. Redox poise and signalling The Drummond lecture Queen Mary, University of London http://plantcell.lu.se/balancing. New Zealand

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The balancing act. Redox poise and signalling The Drummond lecture

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  1. The balancing act. Redox poise and signalling The Drummond lecture Queen Mary, University of London http://plantcell.lu.se/balancing

  2. New Zealand Dr Muriel Emma Bell (CBE) was awarded the William Gibson Research Scholarship for Medical Women of the British Empire by the Royal Society of Medicine. This enabled her to work for three years with Professor Jack Drummond at University College, London. Australia Australian Academy of Science. Victor Martin Trikojus 1902-1985 went to London, where Trik spent some months with Professor Jack Drummond at University College. This gave him the opportunity of extending his contacts with endocrinologists, as well as getting to know one of the great figures in British nutrition. Wales…. David Hughes, the first Professor and Head of Department of Microbiology at Cardiff (1964-1982) brought back happy memories of the golden past. He also brought the house down with his story of Sir Jack Drummond who coated a haddock with yellow phosphorus to demonstrate to medical students, its "bioluminescence". Trouble was his hands glowed in the darkened lecture theatre more strongly than the fish! David Lloyd, Biotype. The Newsletter of the School of Pure & Applied Biology, University of Wales Cardiff. Volume 6 Issue 2 April 1996

  3. Acknowledgements Lund University Plant Cell Biology-Plant Biochemistry http://plantcell.lu.se Thomas Pfannschmidt (Now University of Jena, Germany) Dalibor Stys (Now S. Bohemia University, Czech Republic) Anders Nilsson (Now Bruker Spectroscopy, Lund) Sylvan Dubé (Now Laval University, Canada) Paul Davison (Now Sheffield University, U.K.) H. Louise Race (Now Aylesbury, U.K.) Jens Forsberg Jörgen Ström Boaz Laadan Carol Allen Collaborations Torbjörn Drakenberg, Sture Forsén (Lund Physical Chemistry 2) Gerhard Link (University of Bochum, Germany)

  4. Light 1 Light 2

  5. The balancing act1. Transients, enhancement, and redox poise of cyclic electron flow. Rates and activities of components.

  6. Myers, J. (1971) Annu. Rev.Plant Physiol. 22, 289-312

  7. Hill, R. (1965) Essays Biochem. 1, 121-151

  8. Park, R. B. and Sane, P.V. (1971) Annu. Rev. Plant Physiol.22, 395-430

  9. Photosynthesis Forsberg, J. (2002) PhD thesis. Lund University Blankenship, R. E. (2002) Molecular Mechanisms of Photosynthesis. Blackwell Science, Oxford Heathcote, P. et el. (2002) Trends Biochem. Sci. 27, 79-87

  10. Pfannschmidt, T. et al. (1999) IUBMB Life 48, 271-276

  11. The balancing act2. Protein phosphorylation and state transitions. Post-translational modification of the structure and function of proteins you already have.

  12. Allen, J. F. (1992) BBA 1098, 275-225 . Adapted from Allen, J.F. et al. (1981) Nature 291, 25-29

  13. Dubé, S., Davison, P.A. and Allen, J. F. (unpublished)

  14. State 1 State 2

  15. State 1 State 2 Allen, J. F. and Forsberg, J. (2001) Trends Plant Sci.6, 317-326

  16. Nilsson, A. et al. (1997) JBC 272, 18350-18357

  17. The balancing act3. Redox control of gene expression. Changing transcription and the stoichiometry of complexes.

  18. Allen, J. F. (1992) BBA 1098, 275-225

  19. Pfannschmidt, T. et al. (1999) IUBMB Life 48, 271-276

  20. The balancing act4. Redox signalling and evolution. Why chloroplasts (and mitochondria…) have genomes

  21. Race, H. L., Herrmann, R. G. and Martin, W. (1999) Trends Genet. 15, 364-370

  22. Allen, J. F. (1993) J. Theor. Biol. 165, 609-631

  23. Chloroplast genes and gene products Allen, J. F. (1993) J. Theor. Biol. 165, 609-631

  24. The balancing act. Redox poise and signalling • Transients, enhancement, and redox poise of cyclic electron flow. • Protein phosphorylation and state transitions. • Redox control of gene expression. • Redox signalling and evolution.

  25. Quinone pools: Why is redox poise maintained, apparently by every possible means? • Efficiency. Example - state transitions in oxygenic photosynthesis. • Safety - minimizing single electron transfers to oxygen.

  26. The balancing actPostscript. The Q-cycle, quinone and superoxide anion radicals. The mitochondrial theory of ageing, and the evolution of sex.

  27. Mitochondrial genes and gene products Allen, J. F. (1993) J. Theor. Biol. 165, 609-631

  28. Crofts, A.R., et al. (1998) In Proceedings of the IXth. International Symposium on Phototrophic Prokaryotes, Vienna, (Peschek G., ed.)

  29. ALLEN, J F (1996) J. Theor. Biol. 180, 135-140

  30. Thank you for your attention

  31. The balancing act. Redox poise and signalling The Drummond lecture Queen Mary, University of London http://plantcell.lu.se/balancing

  32. ALLEN, J F (1996) J. Theor. Biol. 180, 135-140

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