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NEUMIC

NEUMIC. Project No. IST-1999-29091. Neurons and Modified CMOS Integrated Circuits Interfacing. Imec The Hebrew University of Jerusalem Physics, Chemistry,Biology. Neuro-Electronic Synapse (NES): interact with neuronal communication. action potential. neurotransmitter. eNES. cNES.

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NEUMIC

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  1. NEUMIC Project No. IST-1999-29091 Neurons and Modified CMOS Integrated Circuits Interfacing Imec The Hebrew University of Jerusalem Physics, Chemistry,Biology

  2. Neuro-Electronic Synapse (NES):interact with neuronal communication action potential neurotransmitter eNES cNES bi-directional electrical communication uni-directional chemical communication

  3. Neurons on a chip

  4. Recorded action potential RAW V [102uV] FILTERED (100-1500Hz) V [mV] V [mV] FG tor output time [sec] time [sec] intracellular voltage V [102uV] time [sec] time [sec]

  5. molecular recognition event modulated current A hybrid transducerfor molecular recognition events neuronal pre-synaptic element “artificial acetylcholine synapse” modulated current electronic post-synaptic element

  6. cNES: towards an artificial synapseAcetylCholine-Esterase ISFET SAM of AChE ACh fast (35 sec) & sensitive (10-8 M) acetic acid

  7. Achievements so far, and future • Fabrication of 1st generation experimental Si neuron transistor chip • (single neurons, extended floating gate, depletion type,shielding metals, • SiO2 Ta2O5) • New package designed and realized • (flip chip bumping, large exposure of Si area, easy access microscope, • microprobes..) • Recorded signals from stimulated neurons cultivated on chip • Experimental verification of “Molecular amplifiers” based on • chromophores • Improved neuron adhesion layer, next to polylysine • Assessment and verification of chemical sensing principle by direct and • quantized measurements of ACh • Second generation transistors designed, processing start end of December • (improved S/N, improved processing, multiple neurons, bi-directional…) • Selection of improved surface biologization molecules and patterning • Direct measurement of ACh on chip • On chip stimulation and recording of neurons

  8. Conclusion No major delays on deliverables Interactiva’s tasks have been divided between partners Expected successful completion of 3th year if extension till December 2003, no show stopper yet Second run and purchase of peptides, sacharides necessary and possible after administrative problems are solved, expected December 2002 Agreement from project officer obtained summer 2002

  9. Changes to the workplan Second generation transistors Surface biologization Technology implementation plan

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