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Practical applications of three-way junction structural motifs

Practical applications of three-way junction structural motifs. with (mostly) Steven Taylor, Renjun Pei. More on junctions:. Kallenbach & Seeman, 1990s’, Kato’s group 1999. What do we do with crossreactive junctions?. Cocaine. Corticosterone. Cholic acid. +. +. -. -. +. +.

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Practical applications of three-way junction structural motifs

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  1. Practical applications of three-way junction structural motifs with (mostly) Steven Taylor, Renjun Pei

  2. More on junctions: Kallenbach & Seeman, 1990s’, Kato’s group 1999

  3. What do we do with crossreactive junctions? Cocaine Corticosterone Cholic acid + + - - + + Stojanovic et al, JACS, 2003

  4. In a way, two sensors together are more powerful: … and even more sensors make cross-reactive array

  5. How able are cross-reactive arrays?

  6. How to make high resolution crossreactive array?

  7. But, first, we find suitable sensors: Yingfu Li, JACS 2003. Pei&Shen

  8. High-resolution CRA for alkaloids (and steroids) Pei&Shen, Olah

  9. Recognition of diastereomers: 4 3 3 3 4 4 2 1 1 1 2 2 Pei&Shen

  10. Visualization and analysis Pei&Shen, Olah

  11. Practical applications: Detection of Inborn Errors in Steroid Metabolism -e.g.: congenital adrenal hyperplasia (all types), errors in bile acid metabolism.

  12. We set up an assay: Taylor, Pei et al. Angew. Chem., 2009

  13. What can we release from an aptamer with quinine? Taylor et al. Angew. Chem., 2009

  14. Can we mimic the pattern of natural release? Taylor et al. Angew. Chem.

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