Thyroid Treatment and Vitamin D Update

1. A CPMC Regional CME Event Thyroid Treatment and Vitamin D Update - An Integrated Approach Saturday October 27, 2012

2. Thyroid Surgery Andrea H. Yeung, MD San Francisco Otolaryngology Medical Group

3. Outline of Discussion • Indications • Risks • Technical considerations • Postoperative management and follow up

4. Disclosures No Financial Disclosures

5. Rising incidence of thyroid cancer over time Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov). SEER Stat Database: Incidence - SEER 9 Regs Public-Use, Nov 2005 Sub (1973-2003), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2006.

6. Increased incidence in Women Sipos JA, Mazzaferi EL. Thyroid Cancer:Epidemiology and Prognostic Variables. Clinical Oncology. 2010 22(6) 395-404 Age at the time of diagnosis of thyroid cancer in men and women from 1975 to 2006. The incidence rate per 100 000 is about 3-fold higher in women compared with men, and peak incidence occurs nearly 20 years earlier in women than men.

7. Increased incidence due to rise in small papillary tumors Davies L, Welch HG. JAMA 2006. 295(18) Cramer JD, Fu P, Harth KC, et al. Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry. Surgery. 2010;148:1147-1153

8. Thyroid cancer incidence and Mortality 1973-2002 Davies L, Welch HG. JAMA 2006. 295(18)

9. Increasing incidence of thyroid nodules • Predominantly due to increased detection of small papillary cancers • Increased diagnostic scrutiny • Known existence of a substantial reservoir of subclinical cancer • Stable overall mortality • Increasing incidence reflects increased detection of subclinical disease, not an increase in true occurrence of thyroid cancer

10. Indications for thyroid surgery • Thyroid malignancy • Symptomatic goiter • Compressive symptoms • Aesthetic concerns due to goiter • Medically refractory hyperthyroidism • Contraindications • Uncontrolled severe hyperthyroidism • Pregnancy

11. Goals for surgical therapy for Differentiated Thyroid Cancer Remove the primary tumor, disease that has extended beyond the thyroid capsule, and involved cervical lymph nodes Minimize treatment related morbidity Permit accurate staging of the disease Facilitate postop treatment with RAI Permit accurate long term surveillance for disease recurrence Minimize the risk of disease recurrence and metastatic spread

12. What is the appropriate operation? • Nondiagnosticbx or indeterminate biopsy • Initial lobectomy with possible need to return for completion thyroidectomy • Follicular neoplasm or Hurthle cell neoplasm • Total thyroidectomy • Large tumors >4cm • Marked atypia is seen on biopsy • Biopsy is suspicious for papillary thyroid carcinoma • Family history of thyroid carcinoma • History of radiation exposure

13. Surgery for Biospy dx of malignancy • Total thyroidectomy • >1cm • Contralateral thyroid nodules present • Regional and distant metastases • Personal history irradiation • First degree family history of thyroid cancer • Older age >45 because of higher recurrence risk • Thyroid lobectomy • <1cm • Low risk • Unifocal disease • Intrathyroidal PTC in the absence of prior radiation or involve cervical nodal mets

14. Lymph node dissection • Central neck dissection (level VI) • Therapeutic for clinically involved central or lateral neck LN • Prophylactic with PTC with clinically uninvolved central neck LN • Advanced primary tumors (T3 and T4) • Total thyroidectomy without prophylactic CND • Small T1 or T2 noninvasive, clinically node negative PTCs and most follicular cancers • Lateral neck dissection • Biopsy proven metastatic lateral cervical LAD

15. Risks • Hypocalcemia related to hypoparathyroidism • transient hypocalcemia vary in the literature from between 5-50% • Permanent hypocalcemia secondary to hypoparathyroidism (ie, lasting more than 6 months) 0.5-2% • Recurrent laryngeal nerve injury • Permanent RLN paralysis occurs in 1-2% of thyroidectomies • Superior laryngeal nerve injury • Often asymmptomatic but may result in vocal fatigue and pitch alteration in professional singers • Hematoma • Infection • Thyrotoxic storm

16. Intraoperative Nerve monitoring Endotracheal tubes with integrated surface electrodes that contact the vocal cords Allows for an intraoperative assessment of nerve function May not have a significant difference in reducing nerve injury, but can be used to predict how well the nerve functions postoperatively

17. Technique Incision and exposure of thyroid gland Releasing the superior pole Identifying the parathyroid glands Identifying the recurrent laryngeal nerve Removing the thyroid gland Neck dissection Closure

18. Incision and exposure of the thyroid gland

19. Releasing the superior pole

20. Identifying parathyroid glands

21. Identifying recurrent Laryngeal nerve

22. Neck dissection

23. Removal of thyroid and Closure

24. Alternatives techniques and methods • Minimally invasive video assisted thyroidectomy • Requires careful patient selection to ensure feasibility • Decreased postop pain and faster recovery • Increased operative time and cost • Robotic assisted transaxillary thyroidectomy • Better cosmetic result • More invasive with wider dissection necessary • Technically difficult • Cost prohibitive

25. Other considerations: substernal goiter • Most often does not require a sternotomy • These patients are at an increased risk of recurrent laryngeal nerve injury, with reports as high as 17.5%. • Sternotomy • Superior vena cava syndrome • Goiter with mediastinal blood supply • Posterior mediastinalgoiter • Larger diameter to the intrathoraciccomponent • Recurrent substernalgoiters • Malignancy extending into the mediastinum • Presence of significant adhesions to mediastinal vessels or pleura

26. Postoperative course • Hemithyroidectomy • 6 week postop TFTs 15% chance need for thyroid hormone replacement • Total thyroidectomy • Calcium monitoring for iatrogenic hypoparathyroidism • Parathyroid hormone as an adjunct or replacement to measuring serum calcium levels in predicting hypoparathyroidism • 6 month postop ultrasound and Tg for survellience

27. Pearls As diagnostic techniques have become more sensitive particularly with the advent of ultrasound and FNA increasing incidence of thyroid cancer may reflect an increased diagnostic scrutiny The surgical technique of thyroidectomy, as well as adjunct technology, continued to advance Most recently, various new instruments and approaches including video-assisted thyroidectomy and robot-assisted thyroidectomy have emerged