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HİPERHİDROZ’UN MEDİKAL TEDAVİSİ NE KADAR GÜVENLİ?

HİPERHİDROZ’UN MEDİKAL TEDAVİSİ NE KADAR GÜVENLİ?. Prof.Dr.Ümit Ukşal. HİPERDROZLAR. PRİMER Lokalize Generalize SEKONDER İlaçlar nedeniyle Hastalıklar. Hiperhidroz yaşam kalitesini bozan bir durumdur. HİPERHİDROZ’DA MEDİKAL TEDAVİ SEÇENEKLERİ. LOKAL TEDAVİLER

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HİPERHİDROZ’UN MEDİKAL TEDAVİSİ NE KADAR GÜVENLİ?

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  1. HİPERHİDROZ’UN MEDİKAL TEDAVİSİ NE KADAR GÜVENLİ? Prof.Dr.Ümit Ukşal

  2. HİPERDROZLAR • PRİMER • Lokalize • Generalize • SEKONDER • İlaçlar nedeniyle • Hastalıklar

  3. Hiperhidroz yaşam kalitesini bozan bir durumdur

  4. HİPERHİDROZ’DA MEDİKAL TEDAVİ SEÇENEKLERİ • LOKAL TEDAVİLER • Aluminyum klorür hekzahidrat%15-25 • Glutaraldehid %5-10 • Methenamine % 10 • Iontoforez • Botulinum toksin enjeksiyonu • Mikrodalga cihaz ile ter bezi kanalının tahrip edilmesi • SİSTEMİK TEDAVİ • Antikolinerjikler: Methenamin bromid • Trisiklik antidepresanlar • Beta blokerler • Kalsiyum kanal blokerleri.

  5. LOKAL TEDAVİLERİN YAN ETKİLERİ • Aluminyum klorür, glutaraldehid, methenamin: İrritasyon, yanma hissi, kontakt dermatit. İontoforez: Eritem, lokal yanma hissi, nadiren vezikül veya bül oluşumu • Botulinum toksini: Ağrı, güçsüzlük, anestezi komplikasyonları, morarma

  6. ANTİPERSPİRANLAR MEME KANSERİNE NEDEN OLABİLİR Mİ? • Deneysel ve biyolojik olarak meme Ca riski ile ilişki kuşkusu neden ortaya çıktı? • Meme Ca riski ile klinik ilişki kanıtı var mı? • Pub Med de bu konudaki yayınlar

  7. Yayınlar • Mc Grath KG . An earlier age of breast cancer diagnosis related more frequent use of antiperspirants/deodorants andunderarm shaving. Eur J Cancer 2003;12(3):479-85 • Exley C, Charles LM, Barr L, Martin C, Polwart A, Darbre PD. Aluminium in human breast tissue. J Inorg Biochem. 2007 Sep;101(9):1344-6. Epub 2007 Jun 12. • Darbre PD. Underarm antiperspirants/deodorants and breast cancer. Breast Cancer Res 2009; 1:1-5 • McGrath KG.Med Hypotheses. 2009 Jun;72(6):665-74. Apocrine sweat gland obstruction by antiperspirants allowing transdermal absorption of cutaneous generated hormones and pheromones as a link to the observed incidence rates of breast and prostate cancer in the 20th century. • Mannello F, Tonti GA, Medda V, Simone P, Darbre PD. J Appl Toxicol. 2011 Apr;31(3):262-9. doi: 10.1002/jat.1641. Epub 2011 Feb 21. • Analysis of aluminium content and iron homeostasis in nipple aspirate fluids from healthy women and breast cancer-affected patients. • Namer M, Luporsi E, Gligorov J, Lokiec F, Spielmann M. The use of deodorants/antiperspirants does notconstitute a risk factor for breast cancer]. • Bull Cancer. 2008 Sep;95(9):871-80. Review. • Watson LC, Gies D, Thompson E, Thomas B. • Randomized control trial: evaluating aluminum-based antiperspirant use, axilla skin toxicity, and reported quality of life in women receiving external beam radiotherapy for treatment of Stage 0, I, and II breast cancer. • Int J Radiat Oncol Biol Phys. 2012 May 1;83(1):e29-34. • . • Sappino AP, Buser R, Lesne L, Gimelli S, Béna F, Belin D, Mandriota SJ. • Aluminium chloride promotes anchorage-independent growth in human mammary epithelial cells. • J Appl Toxicol. 2012 Mar;32(3):233-43. doi: 10.1002/jat.1793. Epub 2012 Jan 6.

  8. Sonuç • Aluminyum tuzu içeren antiperspiranlar erken yaşlarda ve uzun süreli kullanılmamalıdır. • Aluminyum tuzları kullanımı esnasında kıllar traş edilmemeli, travmadan sakınılmalıdır. • Deneyimli ellerde botulinum enjeksiyonu en etkili ve en güvenli yöntem olarak kabul edilebilir.

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