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Palliative Single 8 Gy Radiotherapy for Symptomatic Aggressive Lymphomas

2666 Ａ -408. Palliative Single 8 Gy Radiotherapy for Symptomatic Aggressive Lymphomas. Oguchi M, Eba J, Tanaka O, Kozuka T, Murofushi K, Toshiyasu T, Tsurugai Y, Onoe T, Nose T, Yamashita T . Dept. Radiation Oncology. Cancer Institute Hospital

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Palliative Single 8 Gy Radiotherapy for Symptomatic Aggressive Lymphomas

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  1. 2666 Ａ-408 Palliative Single 8 GyRadiotherapy for Symptomatic Aggressive Lymphomas Oguchi M, Eba J, Tanaka O, Kozuka T, Murofushi K, Toshiyasu T, Tsurugai Y, Onoe T, Nose T, Yamashita T . Dept. Radiation Oncology. Cancer Institute Hospital The Japanese Foundation for Cancer Research, Tokyo

  2. Background Several studies have shown the value of 4 Gy involved field radiotherapy (IFRT) in recurrent indolent lymphomas. Aggressive lymphomas have been initially treated with higher dose of IFRT than indolent lymphomas. The palliative radiotherapy for aggressive lymphomas has rarely been documented.

  3. Purpose/Objective To determine the efficacy and safety of single 8 Gy palliative radiotherapy for patients with symptomatic refractory or advanced aggressive lymphomas.

  4. Materials/Methods: This retrospective analysis consists of 75 sites in 28 patients with refractory aggressive lymphomas and impaired PS. The 8 Gy single fractionation involved field radiotherapy was administered in each site with appropriate techniques from 2002 to 2008. (PTV = GTV + 1 cm margin)

  5. Patients: Their symptoms included pain, discomfort, bulky mass, jaundice and obstruction. Median age was 72 years old (range: 40-94). A median of 3 prior regimens of intensive chemotherapy were proceeded local palliative radiotherapy. The median follow up was 6 months. (range: 3-40)

  6. Results: Effectiveness Median time to symptomatic progression was 4 months (range: 0-40). 89%

  7. Results: Effectiveness Median time to progression in tumor size was 4 months (range: 0-40). 64%

  8. Results: Toxicity Temporary grade 1 acute mucositis was found in 3 sites irradiated to the head & neck mass. Retreatment was needed for 5 sites due to their persistent pain.

  9. Case presentation Post-XRT: 7 months PET/CT Pre-XRT Gad-T1 MR

  10. Conclusions Palliative radiotherapy of 8 Gy single fractionation is valuable asset in the management of patients with symptomatic refractory or advanced aggressive lymphomas.

  11. Acknowledgement Cancer Institute Hospital Dept. Medical Oncology / Hematology Drs. Hatake, Terui, Yokoyama, etc Cancer Institute Dept. Pathology Dr. Takeuchi K.

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