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Innovative Wet Grinding Solutions for Pharma and Cosmetics Industries

Explore the latest advancements in wet grinding technology for pharmaceutical and cosmetics applications at the Hans Brogli event. Learn about differentiating between dry and wet grinding, destroying agglomerates, wetting, and dispersing in fluids. Discover various grinding aggregates like perforated disc mills, toothed colloid mills, and Corundum stone mills. The event showcases the Modula system for easy customization and various CoBall mills for fine grinding. Benefit from adjustable grinding parameters for optimum results. See practical applications in pharmaceutical suspensions, ointments, cosmetics creams, and more. All machinery follows GMP guidelines, offering easy maintenance and high efficiency for processing various viscosities. Upgrade your production capabilities with these cutting-edge wet grinding solutions.

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Innovative Wet Grinding Solutions for Pharma and Cosmetics Industries

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  1. TechnologyofWet Grinding Pharma and Cosmetics 25.- 28.October 2003 Hans Brogli Pharma/Cosmetics

  2. Contents • Definition Grinding, Wet Grinding • Characterisation • Modula Grinding Aggregates • Annular Gap Mill CoBall-Mill • Applications • Summary Pharma/Cosmetics

  3. Grinding We differentiate between: Dry Grinding • Grinding • Dispersing Wet Grinding Pharma/Cosmetics

  4. Wet Grinding Grinding Crushing of solid matters, crystals or fibres in small parts in a fluid, e.g. active substances, colour pigments Pharma/Cosmetics

  5. Wet Grinding destroying of agglomerates, wetting and homogeneous dispersing in a fluid, e.g. toothpaste, lipstick Dispersing Emulsifying • merging of two not mixable fluids (oil, water) under the effect of shear forces, turbulences and an emulsifier e.g. ointments, body cream Pharma/Cosmetics

  6. Characterisation • Effect of mechanical forces Different products are milled on our mills by impact, pressure, shear forces, cutting or friction • Resistability - hard-elastic, fibrous fruit flesh, coconut flesh, aloe vera plants - hardness of crystalline parts up to mohs hardness 9.5 Pharma/Cosmetics

  7. Continuous Mills Perforated Disc Mills Toothed Colloid Mill Corundum Stone Mill In-Line Homogenizer Annular Gap Mill CoBall-Mill Wet Grinding Pharma/Cosmetics

  8. “Modula“ Modula The new dimension Pharma/Cosmetics

  9. Grinding Aggregates Mills M/ML, M/MZ, M/MKOpen Execution, Outlet open Feeding with hopper Feeding with hopper and feeding screw Feeding with pump In-line ExecutionClosed Execution, Outlet pipeline • Inlet connected to a tank • Feeding with pump Pharma/Cosmetics

  10. Perforated Disc Mill Pharma/Cosmetics

  11. Perforated Disc Mill M/ML Crushing, Pre-grinding • Size up to 100 mm • Fineness approx 1 mm The desired fineness is adjusted by the size of the holes in the perforated discs Hole dia. 1.5 to 20 mm or slotted discs Pharma/Cosmetics

  12. Toothed Colloid Mill M/MZ Pharma/Cosmetics

  13. Toothed Colloid Mill M/MZ Fine Grinding • Starting size depending on product up to 5mm • Fineness approx 100 µ The desired fineness is adjustable with • Toothing, coarse, normal, crosswise • Grinding gap infinitely adjustable (gap between rotor and stator) Pharma/Cosmetics

  14. Corundum Stone Mill M/MK Pharma/Cosmetics

  15. Corundum Stone Mill Finest Grinding • Fineness 30 - 50 µ The desired fineness is adjustable with • Different graining of grinding discs grain 20 to 120 • Grinding gap infinitely adjustable (gap between rotor- and stator disc) Pharma/Cosmetics

  16. Modula Pharma/Cosmetics

  17. Modula Pharma/Cosmetics

  18. Modula - Range Pharma/Cosmetics

  19. Modula M/DIL Dispersing, crushing of agglomerates Emulsifying Exchangeable rotor-, stator elements, different toothing Pharma/Cosmetics

  20. Modula M/DIL Pharma/Cosmetics

  21. M/DIL - Range Pharma/Cosmetics

  22. Annular Gap CoBall Mill Pharma/Cosmetics

  23. product outlet coolingmediumoutlet coolingmedium product inlet Processing CoBall Mill beads outlet Pharma/Cosmetics

  24. CoBall Mill Finest grinding down to the Nano range < 0.5 µ Adjusting Possibilities • Rotor speed • Diameter of grinding beads and grinding gap (rotor). • Material of grinding beads (spec. weight) • Degree of beads filling • Capacity • Product temperature • Product viscosity (contents of dry substances) Pharma/Cosmetics

  25. CoBall Mill MS-12 MS-50 Pharma/Cosmetics

  26. CoBall Mill Advantages • Narrow grinding gap (four times beads diameter) high energy density  narrow grain spectrum • Optimum cooling, all surfaces rotor, stator, lid coolable • Smooth grinding elements resistant to wear, no pins, naps etc. Pharma/Cosmetics

  27. CoBall Mill • Products from fluid to very viscous can be processed • Cleaning, sterilizing and drying without emptying of grinding beads • Small grinding chamber volume - Little remnants at product change - Quick cleaning, little consumption of cleaning material - Easy and efficient change of products Pharma/Cosmetics

  28. CoBall Mill - Range Pharma/Cosmetics

  29. Applications Pharma suspensions, ointments, veterinary products, eye drops, tablet coating, active-substances, clotrimazole, betametasone, etc. Cosmetics creams, emulsions, lipstick, nail polish, mascara, eye shadow, titandioxyde, animal skins, shrimp shells, plants, roots, aloe vera etc. Pharma/Cosmetics

  30. Summary • All mill types are constructed according to GMP guidelines • All mills can be equipped with CIP, SIP and DIP • Delivery with all qualification documents, possibility of validation • All lubricants with USDA-H1 admission • For clean rooms all mills can be delivered with water cooled motors (no turbulences) • Products with a viscosity from fluid to highly viscous can be processed • Due to the new modular construction all mills are easy to handle and quickly convertable Pharma/Cosmetics

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