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16 November 2009 Cardiovascular Physiology

16 November 2009 Cardiovascular Physiology. Lab this week: Frog Heart Physiology Bring Textbook to lab. Test # 3 is Monday, Nov 23 rd . MAP = CO x TPR. MAP = (HR x SV) x TPR. Mean Arterial Pressure = Cardiac Output x Total Peripheral Resistance. Fig. 12.50. Receptors for other ligands.

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16 November 2009 Cardiovascular Physiology

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  1. 16 November 2009Cardiovascular Physiology Lab this week: Frog Heart PhysiologyBring Textbook to lab. Test # 3 is Monday, Nov 23rd.

  2. MAP = CO x TPR MAP = (HR x SV) x TPR Mean Arterial Pressure = Cardiac Output x Total Peripheral Resistance

  3. Fig. 12.50

  4. Receptors for other ligands Alpha receptors more common except in skeletal muscle arterioles which have more B2 receptors

  5. 3 Fig. 12.36 Metabolic vasodilators No parasympathetic innervation of arterioles! Importance of sympathetic “tone.” Metabolic autoregulation, flow autoregulation, myogenic autoregulation

  6. 4 Figure 12.02 Arteries = 10% of Blood Volume Veins = 60% of Blood Volume Arterioles = Resistance vessels Capillaries = 5% of Blood Volume

  7. 5 Capillaries: Continuous, discontinuous, and fenestrated capillaries: Ex: brain and liver Figure 12.38 Generate vasodilators and vasoconstrictors Arterioles: 1) Extrinsic control by hormones and nerves2) Intrinsic (local) control by …..a) metabolic autoregulation, …..b) flow autoregulation, and …..c) myogenic autoregulation.

  8. 8 Diffusion, mediated transport, bulk flow

  9. 7 Fig. 12.40 Diffusion is the most important mode of exchange of nutrients

  10. 9 Figure 12.41 Colloids Crystalloids Bulk Flow

  11. 10 Bulk Flow through aqueous channels and intracellular clefts Figure 12.42 Starling Forces Regulated by arterioles Net filtration = 4L/day Main difference in the Pulmonary circuit?

  12. Fig. 12.43 Pc Pc Pc

  13. 12 Figure 12.47 Fate of 4 L/d excess filtrate Liver & Bone Marrow

  14. Figure 12.47

  15. 11 Who Cares? Aunt Esther Physiology of support hose

  16. Figure 12.60 OrthostaticHypotension

  17. 13 Figure 12.44 Veins areCapacitance vessels(high compliance)with valves for unidirectional flow Arteries are low compliance

  18. Fig. 12.53 MAP = CO x TPR Negative feedback control:stimulus, receptors, afferent pathway(s), integrator, efferent pathway(s), effector(s)response(s)

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