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Current and future trends in industry Where academic life sciences

Current and future trends in industry Where academic life sciences research and education need to go. Keith Yamamoto keith.yamamoto@ucsf.edu http://yamamotolab.ucsf.edu UCB Postdoc Industry Exploration Program September 27, 2012. Life sciences research at an inflection point.

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Current and future trends in industry Where academic life sciences

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  1. Current and future trends in industry Where academic life sciences research and education need to go Keith Yamamoto keith.yamamoto@ucsf.edu http://yamamotolab.ucsf.edu UCB Postdoc Industry Exploration Program September 27, 2012

  2. Life sciences research at an inflection point quantitative understanding, solutions to big problems data collection, detailed description How move through the inflection point? • Merge sciences: incorporate concepts and technologies of physics, chemistry, engineering, math, computer science • Build working continuum: from fundamental discovery, to application, to addressing societal issues It’s time to rethink life sciences research and education

  3. Challenges/Expectations for Research & Education Mission/Goals for the PhD • Specialized expertise • Mentored, original, bold research • Broad literacy and perspective • Team-based research • Math/statistics/computation skills • Three “tools of the trade” • Working familiarity with career options • Mission/Goals for the Postdoc • Progression to independent team-based research • Management skills for the practice of science

  4. Challenges/Expectations for Research Education Mission/Goals for the PhD • Specialized expertise • Mentored, original, bold research • Broad literacy and perspective • Team-based research • Math/statistics/computation skills • Three “tools of the trade” • Working familiarity with career options • Mission/Goals for the Postdoc • Progression to independent team-based research • Management skills for the practice of science • Training period much too long!

  5. The Perilous, Slow Transition to Independence • Median age, first independent position: 38 • Median age, first R01: 42 • Percent NIH awards to new investigators: 4 Einstein Nirenberg Cech First Position: 32 33 31 Nobel Prize: 42 41 42 >> Need to train more efficiently: 4-8 years?

  6. Identify important problem • Design experiments • Select results for follow-up Challenges/Expectations for Research Education Mission/Goals for the PhD • Specialized expertise • Mentored, original, bold research • Broad literacy and perspective • Team-based research • Math/statistics/computation skills • Three “tools of the trade” • Working familiarity with career options • Mission/Goals for the Postdoc • Progression to independent team-based research • Management skills for the practice of science

  7. A PhD “hub” with career option “spokes” BSc Teaching Education Admin Journalism Information media Education Communication PhD Law Business Science policy Intellectual property Patent Postdoc Biotech startup Venture capital Independent investigator Academia, Biotech, Pharma

  8. Challenges/Expectations for Research Education Mission/Goals for the PhD • Specialized expertise • Mentored, original, bold research • Broad literacy and perspective • Team-based research • Math/statistics/computation skills • Three “tools of the trade” • Working familiarity with career options • Mission/Goals for the Postdoc • Progression to independent team-based research • Management skills for the practice of science

  9. Mentored career exploration 10-week internships in business, law, communication, education, policy

  10. A PhD “hub” with career option “spokes” BSc Teaching Education Admin Journalism Information media Education Communication PhD Law Business Postdoc Science policy Intellectual property Patent Biotech startup Venture capital Independent investigator Academia, Biotech, Pharma

  11. Challenges/Expectations for Research Education Mission/Goals for the PhD • Specialized expertise • Mentored, original, bold research • Broad literacy and perspective • Team-based research • Math/statistics/computation skills • Three “tools of the trade” • Working familiarity with career options • Mission/Goals for the Postdoc • Progression to independent team-based research • Management skills for the practice of science • OR: Independent Fellows program

  12. Challenges/Expectations for Research Education Mission/Goals for the PhD • Specialized expertise • Mentored, original, bold research • Broad literacy and perspective • Team-based research • Math/statistics/computation skills • Three “tools of the trade” • Working familiarity with career options • Mission/Goals for the Postdoc • Progression to independent team-based research • Management skills for the practice of science

  13. Build integrated, team-based research culturesome UCSF approaches and experiments:-- BootCamps: 2 day intensive orientations-- Team Challenges: 4-5 day competitions-- Minicourses: 2.5 week immersion, team-based-- Design-science summer project-- UCSF PKU Team Challengeand an enabling tool:-- Knowledge network to integrate research approaches, data and investigators

  14. Challenges/Expectations for Research Education Mission/Goals for the PhD • Specialized expertise • Mentored, original, bold research • Broad literacy and perspective • Team-based research • Math/statistics/computation skills • Three “tools of the trade” • Working familiarity with career options • Mission/Goals for the Postdoc • Progression to independent team-based research • Management skills for the practice of science

  15. Day science calls into play arguments that mesh like gears, results that have the force of certainty… Conscious of its progress, proud of its past, sure of its future, day science advances in light and glory. By contrast, night science wanders blind, it hesitates, stumbles, recoils, sweats, wakes with a start. Doubting everything, it is forever trying to find itself, question itself, pull itself back together. Night science is a sort of workshop of the possible, where what will become the building material of science is worked out. • Francois Jacob If at first the idea is not absurd, then there is no hope for it. -Albert Einstein

  16. Future of academic research & education? Mission/Goals for the PhD • Specialized expertise • Mentored, original, bold research • Broad literacy and perspective • Team-based research • Math/statistics/computation skills • Three “tools of the trade” • Working familiarity with career options • Mission/Goals for the Postdoc • Progression to independent team-based research • Management skills for the practice of science

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