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Standard analysis

Supplementary Figure 2. Adjusted for cell type. Standard analysis. SVA. Cross-sectional at T0. λ = 1.081. λ = 1.111. λ = 1.007. (B) Cross-sectional at T1. λ = 0.981. λ = 0.962. λ = 1.040. 8. 8. 6. 6. 4. 4. -log 10 (observed p value). -log 10 (observed p value). 2.

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Standard analysis

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  1. Supplementary Figure 2 Adjusted for cell type Standard analysis SVA Cross-sectional at T0 λ = 1.081 λ = 1.111 λ = 1.007 (B) Cross-sectional at T1 λ = 0.981 λ = 0.962 λ = 1.040 8 8 6 6 4 4 -log10(observed p value) -log10(observed p value) 2 2 0 0 0 0 0 1 1 1 2 2 2 3 3 3 4 4 4 5 5 5 6 6 6 -log10(expected p value) -log10(expected p value) -log10(expected p value)

  2. Standard analysis (C) Longitudinal λ = 1.023 8 6 4 -log10(observed p value) 2 0 0 1 2 3 4 5 6 -log10(expected p value)

  3. (D) Cross-sectional at T0 (E) Cross-sectional at T1 (F) Longitudinal 1 0 ICC

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