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CHE5480 Summer 2005

CHE5480 Summer 2005. Dendrimers June 14, 2005. Starburst Dendrimers. What is a dendrimer? Branched polymers ( dendron = tree in Greek) Functionality = 3 (Nitrogen). Silicon, Si, functionalty f=4. Rose bengal inside PPI dendrimer. Dendrimers:. 1. Manufacture 2. Structure

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CHE5480 Summer 2005

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  1. CHE5480 Summer 2005 Dendrimers June 14, 2005

  2. Starburst Dendrimers

  3. What is a dendrimer? Branched polymers(dendron = tree in Greek)Functionality= 3 (Nitrogen)

  4. Silicon, Si, functionalty f=4

  5. Rose bengal inside PPI dendrimer.

  6. Dendrimers: • 1. Manufacture • 2. Structure • 3. Characterization • 4. Applications

  7. Manufacture: • (i) Divergent Method • (ii) Convergent Method

  8. Methods of Synthesis:(i) Divergent Growth

  9. Methods of Synthesis:(ii) Convergent Growth

  10. Comparison: Divergent vs. Convergent

  11. Structure:

  12. Generations of Dendrimers Your Text Here

  13. Generations of Dendrimers 2nd gen. 5th gen. 4th gen.

  14. PAMAM Dendrimer (polyamidoamine) • Alternating (B)-AB-AB-AB-... • Ethylenediamine (B) • H2N-C-C-NH2 • Methylacrylate (A) • C=C-CO-OCH3

  15. PAMAM Moieties: Diamine Acrylate NH3 or Diamine

  16. Characterization:

  17. f=3 fc=3 1 2 3 generations Spacer b

  18. Construction of Generations: • Core: Ethylenediamine (Moiety B = D) • “Michael Addition” of 4 Methylacrylates (A= O) • Amidization: add 4 ethyldiamines (D) • Result: Generation “0”

  19. Continue Branching: Generation “1”:

  20. Generation “2”:

  21. Calculations: • Note that • Core functionality (2 nitrogens): fc = 4 • Branch functionality (nitrogen): f=3 • No. of Spacers (A+B): b=2 • Generation = G

  22. Number of Branches: Nbr

  23. Number of Mers (A+B): Nmer

  24. Applications of Dendrimers • Gas and chemical sensors • Catalysts • Drug delivery and gene therapy • Surface modifiers (tribology, and information storage) • Bio compatible materials • Electronic devices and antennae

  25. Size of PAMAM DendrimersGeneration M.W. Angstrom (dia.) End Gps (1 nm = 10 Angstroms)

  26. Equivalent Sizes with Cells:

  27. Dendrimer: PAMAM

  28. 2. Nanostructured materials: Gas adsorption in dendrimers

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