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New and ongoing areas of research

New and ongoing areas of research. In the EuroQol Group. New research. International 5L valuation Discussed already EQ-5D-Y Youth version Disease specific adaptations ‘Bolt on’ additional dimensions. EQ-5D-Y: Youth. EQ-5D-Y: Youth. Translations Available in more than 20 languages

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New and ongoing areas of research

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  1. New and ongoing areas of research In the EuroQol Group

  2. New research • International 5L valuation • Discussed already • EQ-5D-Y • Youth version • Disease specific adaptations • ‘Bolt on’ additional dimensions

  3. EQ-5D-Y: Youth

  4. EQ-5D-Y: Youth • Translations • Available in more than 20 languages • Youth between 7-12 years • Proxy versions • In development

  5. Administration seems OK

  6. But not yet a value set • How should value the health states • Children? • Parents? • The general public? • How do you include: • Development backlog? • The remarkable coping skills children?

  7. Are values different • Do we value health states different? • For ourselves • For someone other like ourselves • For a 10-year child • New paper of the 2012 Meeting

  8. Values for children 10% lower

  9. Small number of health states Still VAS Does this also apply for TTO? Complication: How to apply TTO for health states of children? Descriptive system EQ-5d-Y is different! Feedback from the 2012 meeting

  10. Bolt-on • Do we miss dimensions? • In the past: EQ-6D • Mobility; • Daily activity and self care; • Work performance • Family and leisure performance • Pain/discomfort • Present mood • First attempts • EQ-5D+cog: addition of cognition?

  11. EQ-5D+cog • Used in DALY WHO project • Cognition was recognized as important • Lot of discussion • Is it necessary? • Who is making the value set? • An unofficial set exist • Based on mapping DALY project • Is used… • But gives confusion • No official status

  12. Why not other dimensions? • Developed already • Psoriasis • Vision

  13. VF-14 by Visual acuity in macular degeneration

  14. EQ-5D by Visual acuity in macular degeneration

  15. Evidence on EQ-5D: some examples Hearing Schizophrenia Bipolar disorder Vision Depression and anxiety Some cancers Skin Personality disorder

  16. Psoriasis

  17. Estimation of utilities • Used standard EQ-5D-3L TTO protocol • General public interviews in UK only • N = 300 • Sub-set of 49 states were included using orthogonal design

  18. Results • OLS and random effects models estimated • Interaction terms; collapsing levels • Both dimensions have a significant impact • Some inconsistencies in the data • The largest gap is between level 3 and 4 (moderate and severe)

  19. Modeling TTO values Psoriasis

  20. Discussion 2012 meeting • No real problem when seen as pilot • Convenience sample • TTO not standardised • Methodological complications • Things get complicated for responders fast • 223451 versus 122345 • Cognition overload • 57 = 78.125 health states • Similar values for 4th and 5th levels • Modeling stressed to the limit?

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