1 / 29

Clinical laboratory diagnostics of hemoblasosis

Clinical laboratory diagnostics of hemoblasosis. Leukemia definition. Leukemia – it is tumor arising from bloodforming cells and primary lesion bone marrow. Classification of leukemias. Acute leukemias myeloblastic lymphoblastic Chronical leukemias myeloid lynphoid.

mariehudson
Download Presentation

Clinical laboratory diagnostics of hemoblasosis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Clinical laboratory diagnostics of hemoblasosis

  2. Leukemia definition • Leukemia – it is tumor arisingfrom bloodforming cells and primary lesionbone marrow

  3. Classification of leukemias • Acute leukemias • myeloblastic • lymphoblastic • Chronicalleukemias • myeloid • lynphoid

  4. Acutemyeloblasticleukemias • Undifferentiated • Myeloblasticwithoutmaturing • Myeloblasticwithmaturing • Promyelocytic • Myelomonoblastic • Monoblastic • Erythroblastic • Megacaryoblastic

  5. Histochemicalsignsof differentiation ofacute leukemias • 1. Reaction for peroxidase • 2. Reaction for acidity phosphatase • 3. Reaction for uncpecificesterases • 4. Reaction for lipides • 5. Reaction for compoud carbohydrates

  6. Reactionof myeloblastesandother of neutrophil cellsfor peroxidase

  7. Reaction of monoblastesforα-naphtylacetateestherase

  8. Reaction of myeloblastes and monoblastesforacidityphosphatase

  9. Acute lymphoblasticleukemia - blood

  10. Acute В-lymphoblastosis – bone marrowBigvacuolizedlymphoblastes

  11. Acute lymphoblasticleukemia – bone marrrow

  12. Acute lymphoblasticleukemia – bone marrrow. Initial stage.

  13. Acute lymphoblastosis – bone marrow.Totallymphoblasticmetaplasia

  14. Chronicalmyeloidleukemias • Myelocytic • Monocytic • Eosinophilic • Erythroblastic • Megacaryocytic

  15. Chronicalmyelocytic leukemia – blood. Chronicalphase

  16. Chronicalmyelocytic leukemia – blood.

  17. Chronicalmyelocytic leukemia – bloodStage of blastic crisis

  18. Chronical lymphoidleukemias • В-lymphocytic • Т- lymphocytic (1,5 %) • Haircell

  19. Chronical В-celllymphocyticleukemia - blood

  20. Chronicallymphocyticleukemia – blood. Gumprecht’s bodies.

  21. Chronicallymphocyticleukemia – bone marrow. Totallymphoidmetaplasia.

  22. Chronicallymphocyticleukemia – bone marrow. Totallymphoidmetaplasia.

  23. Chronical haircell leukemia - blood

  24. Chronical haircell leukemia - blood

  25. Haircell leukemia - blood. Reaction foracidityphosphatase

  26. Chronical monocytic leukemia - blood

  27. Mechanisms of cellular oncogenes activating • Point mutations • Chromosomal abnormalities • Virualtransduction • Insertionmutagenesis • Genesamplification

  28. Clinicalmanifestation ofleukemia • Metaplastic anemia • Thrombocytopenia • Hemorrhagicsyndrome • Secondaryimmunedeficiency • Decreaseof resistance

  29. Thank for your attention!

More Related