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Neural Stem Cells in Treating Diseases of the CNS

Neural Stem Cells in Treating Diseases of the CNS. Brooke McCarthy BME 281 Fall 2011. Stem Cells. Undifferentiated cells Types Cell division Induced to become specialized cells Physiologically Experimentally. Neural Stem Cells. Most fundamental cell of the nervous system

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Neural Stem Cells in Treating Diseases of the CNS

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  1. Neural Stem Cells in Treating Diseases of the CNS Brooke McCarthy BME 281 Fall 2011

  2. Stem Cells • Undifferentiated cells • Types • Cell division • Induced to become specialized cells • Physiologically • Experimentally

  3. Neural Stem Cells • Most fundamental cell of the nervous system • Divides to create • Neurons • Astrocytes • Oligodendroglia

  4. CNS • Malignant glioblastomas • Multiple sclerosis • Niemann-Pick’s disease • Current treatments

  5. NSC Therapy • Inject • Migrate • Surround

  6. Results • Multiple sclerosis • Niemann-Pick’s disease • Still too early

  7. Pros • Best results • Injection • Either type of stem cell

  8. Problems • Risks • BTSC • Mutation of NSC • Largest part of brain tumors • Resists treatments • Genetic engineering

  9. Future • Genetic engineering • Cellular origins • Other diseases

  10. Resources • Achanta, P. "Gliomagenesis and the Use of Neural Stem Cells in Brain Tumor Treatment." Anticancer Agents Med Chem.(2010): 121-30. Pubmed. Web. 17 Sept. 2011. • “Glioblastoma Multiforme.” Medscape. Web. 14 Sept. 2011. <http:// emedicine.medscape.com/article/283252-overview#showall>. • Taupin, P. "Potential of Neural Stem Cells for the Treatment of Brain Tumors." Clinical Medicine: Oncology. (2008): 451-54. PubMed. Web. 17 Sept. 2011. • “Stem Cell Information.” The National Institutes of Health. Web. 14 Sept. 2011. <http://stemcells.nih.gov/info/basics/basics1.asp>. • “What are Stem Cells?” Medical News Today. Web. 14 Sept. 2011.

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