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Childhood rashes

Childhood rashes. The following items will be discussed: @ Acrodermatitis enteropathica @ Dermatosis affecting the napkin area @ Gianotti- Crosti syndrome Papular acrodermatitis of childhood @ Erythema toxicum neonatorum @ Neonate rashes @ Blueberry muffin babies

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Childhood rashes

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  1. Childhood rashes • The following items will be discussed: • @ Acrodermatitis enteropathica • @ Dermatosis affecting the napkin area • @ Gianotti- Crosti syndrome • Papular acrodermatitis of childhood • @ Erythema toxicum neonatorum • @ Neonate rashes • @ Blueberry muffin babies • @ Subcutaneous fat necrosis of the newborn • @ Neonatal fat necrosis of the newborn • @ Langer

  2. Acrodermatitis enteropathica • It is an eczematous skin rash related to zinc deficiency. It may be congenital or acquired secondary to prematurity or dietary deficiency. The congenital form is due to a mutation in a trasnsmembrane zinc uptakeprotein & is inherited in an autosomal recessive fashion. Features include: • @ Red inflamed patches of dry skin, particularly around body orifices such ass the mouth, anus, eyes & skin on elbows, knees, hands & feet. It may look like ATOPIC DERMATITIS • @ Patches evolve into crusted, blistered, pus filled eroded lesions • @ There is usually sharp demarcation between affected & normal skin • @ Skin around nails becomes inflamed (paronychia) & their may be nail ridging @ Mental retardation • @ Diffuse hair loss on the scalp, eyebrows & eye lashes. • @ Secondary infection with candida albicans & Staph aureus • @ Red glossy tongue & nail ulcers @ diarrhea • @ Impaired wound healing @ Deat • Treatment is with zinc supplement

  3. Acrodermatitis enteropathica

  4. Acrodermatitis enteropathica

  5. Gianotti-Crosti syndromepapular acrodermatitis of childhood • It is a rare eruption that often follows an upper respiratory tract infection& can be associated with mild systemic upset.. It affects children at any age with an equal sex distribution. It is a reaction of the skin to a viral infection: Hepatitis B, Epstein Barr virus are the most frequently reputed etiology. Other incriminated virus: Hepatitis A, cytomegalovirus, coxsacki virus, adenovirus, enterovirus, rubella… • The rash consists of multiple small monomorphus lichenoid papules that may be skin colored or red. It is non-itchy , symmetrical & affects the face, extremities, buttocks, palms & soles. It may be associated with a low grade fever, lymphadenopathy & hepatosplenomegaly. The rash is self limiting & normally settles in 2 – 8 weeks . • Differential diagnosis: Acrodermatitis enteropathica, erythema multiformis, hand,foot & mouth disease, Henoch - Shonlein purpura, Kawasaki disease, lichen planus, papular urticaria, scabies. • Treatment is with emollient. Topical steroid may exacerbate the condition.

  6. Gianotti- Crosti syndrome

  7. Erythema toxicum neonatorum

  8. Erythema toxicum neonatorum • It appears in up to half of neonates carried to term, usually between day 2 -5 after birth. it clears up by 2 weeks of age. It appears as blotching erythematous macules with central vesicles, papules or pustules. It does not require treatment. • It is due to activation of immune system. Some neonates are more sensitive than others& develop erythematous spots all over the body or may be due to hypersensitivity to detergents in bed sheets & clothing

  9. Neonate rashes

  10. Neonate rash Milia in neonate Cutis marmorata in neonate Napkin dedrmastitis in neonate

  11. Childhood rashes Mongolian spot in neonate Miliaria crystallina Acne neonatorum Craddle cap (seborrheic dermatitis)

  12. Blue berry muffin babies Blueberry muffin babies present with widespread rash of blue red papules & nodules at birth, The rash is due to congenital infection in utero

  13. Subcutaneous fat necrosis of thenewborn • It is a rare condition seen in babies of 2-3 weeks of age. It presents with one or more erythematous subcutaneous nodules that may coalesce into plaques. It is often precipitated by cold 7 seen on the trunk, arms buttocks, thighs & cheeks. Rarely, the skin may ulcerate & necrotic fat exude. It can be associated with significant hypercalcemia that may require treatment. The condition is self limiting & resolves over a few months

  14. Subcutaneous fat necrosis of the newborn

  15. Neonatal herpes simplex infection • It occurs during delivery with • Direct spreads from vaginal • Lesions, when lesions do occur they are typically papules that progress to grouped vesicles. The infection may be limited to the skin, involve the central nervous system or can be disseminated. Untreated disseminated infection has a mortality of over 8O%

  16. Langerhans cell histiocytosis • It is a part of clinical histiocytosis which are characterized by abnormal proliferation of histiocytes. It is clinically derived into three groups: • 1. Unifocal LCH( older name is eosinophilic granuloma which is now a misnomer) • 2. Multifocal unisystem LCH. The triad of diabetes insipidus ,exophthalmos& lytic bone lesion is known as Hand- Schuller- Christian triad. • 3. Multifocal multisystem LCH . Also called Letter –Siwe disease • @ Some consider LCH a reactive process. • Argument with: Occurrence of spontaneous remission, extreme secretion of multiple cytokines by dendretic cells& by standers cells in lesional tissue, favorable prognosis& good survival rate without organs involvement • @ Neoplastic process: • Argument supporting: Clonality is an important attribute of cancer; activating mutation of protooncogen in the Raf family. BRAF gene

  17. Langerhans cell histiocytosis

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