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Vertebroplasty Material Analysis by Fourier Transform Infrared Spectroscopy

Vertebroplasty Material Analysis by Fourier Transform Infrared Spectroscopy. Naomi Barth July 15, 2004 Biomaterials Group Advisor: Dr. Marcolongo. What is Human Bone?. 45 - 60 % mineral: Calcium Phosphate 20 - 30 % matrix: collagen 10 - 20 % water. Schematic of the bone tissue.

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Vertebroplasty Material Analysis by Fourier Transform Infrared Spectroscopy

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  1. Vertebroplasty Material Analysis by Fourier Transform Infrared Spectroscopy Naomi Barth July 15, 2004 Biomaterials Group Advisor: Dr. Marcolongo

  2. What is Human Bone? • 45 - 60 % mineral: Calcium Phosphate • 20 - 30 % matrix: collagen • 10 - 20 % water Schematic of the bone tissue. Flahiff CM, Blackwell AS, Hollis JM, Feldman DS. Analysis of a biodegradable composite for bone healing. J Biomed Mater Res 1996;32:419-424.

  3. Comparison of Osteoporosis Bone and Healthy Bone Healthy Bone Osteoporosis Bone http://www.tarjetaweb.org/clientes/lopezolivares/images/huesos.jpg

  4. Effect of Osteoporosis http://www.inpensacola.com/fe/cityguide/seniors/articles/images/osteoporosis.jpg

  5. Methods Already in Use Bone cement is injected into the fractured vertebrae www.nlm.nih.gov

  6. How do we replace bone ? Calcium Phosphate Collagen = BONE Calcium Phosphate / Polymer Composite Synthetic Calcium Phosphate Polymer = • Tailor-made properties simulate natural bone characteristics • Bioactivity at bonding site Aoki H. Science and Medical Application of Hydroxyapatite. JAAS 1991. 11-27, 99-107.

  7. Our proposed material Material at room temperature Material at body temperature Photo reproduction was made under the courtesy of Dr. Marcolongo’s Laboratory

  8. Engineering Design

  9. FTIR – Fourier Transform Infrared http://www.paris.ensam.fr/recherche/WEB-LTVP/images/Materiel/FTIR2.JPG

  10. Key Peaks for Identifying our Polymer Sample 1700 1000 FTIR result was made under the courtesy of Dr. Marcolongo’s Laboratory

  11. Identification of chemical structure (qualitative analysis) Calculation of chemical concentrations (quantitatively analysis) Verification of a successful polymerization Comparison of material to natural bone Why FTIR is Important

  12. Further Analysis • Comparison of the FTIR results of the following samples: • Injectable hydrogel polymer • In vitro immersed hydrogel My Final Goal is to master the FTIR technique, so that I can apply it to my future research work.

  13. Acknowledgements • Dr. Marcolongo • Emily Ho • Jon Thomas

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