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Angiotensinog en. Renin/ProR Receptor. Tonin Cathepsin G. Renin. ACE 2. Ang I. Ang-(1-9). ACE Chymase Cathepsin A. ACE,NEP. PEP, NEP. ACE. Ang-(1- 5 ). Ang II. Ang-(1-7). ACE2 , PEP, PCP. A MP. D-Amp. Ang III. AT 1 , AT 2. AT 1-7 (Mas). A MP. A MP. IRAP / ?.

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AT 1 / ?

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  1. Angiotensinogen Renin/ProR Receptor Tonin Cathepsin G Renin ACE2 Ang I Ang-(1-9) ACE Chymase Cathepsin A ACE,NEP PEP, NEP ACE Ang-(1-5) Ang II Ang-(1-7) ACE2, PEP, PCP AMP D-Amp Ang III AT1, AT2 AT1-7 (Mas) AMP AMP IRAP / ? Ang IV ACE AMP, ACE AT1/ ? Ang-(2-10) Figure 1

  2. Fluid retention Glomerular hypertension Inflammation Glomerulosclerosis ANGIOTENSINOGEN Renin Hypertrophy Hyperplasia Arrhythmia Fibrosis ACE2 ANGIOTENSIN I ANGIOTENSIN-(1-9) PEP ACE NEP ACE ANGIOTENSIN II ANGIOTENSIN-(1-7) ACE ACE2 Vasoconstriction Angiogenesis Thrombosis Endothelial dysfunction ANGIOTENSIN-(1-5) PEP, PCP Baroreflex inhibition AVP release Dipsogenic action Sympathetic stimulation Figure 2

  3. Increase of renal blood flow Sodium and water handling Anti-fibrosis? ANGIOTENSINOGEN Renin ANGIOTENSIN I ACE2 ANGIOTENSIN-(1-9) ACE PEP NEP ACE ACE ANGIOTENSIN II ANGIOTENSIN-(1-5) ANGIOTENSIN-(1-7) ACE2 PEP, PCP Anti-hypertrophy Anti-hyperplasia Anti-arrhythmia Anti-fibrosis Vasodilatation Anti-angiogenesis Anti-thrombosis Anti-proliferation Baroreflex facilitation AVP release Sympathetic tonus modulation Figure 3

  4. Angiotensinogen Renin ACE2 Angiotensin-(1-9) Angiotensin I ACE ACE ACE2 Angiotensin-(1-7) Angiotensin II AT1 Receptor AT2 Receptor Mas Vasopressor Proliferative Profibrotic Vasodilator Anti-proliferative Anti-fibrotic Vasodilator Anti-proliferative Figure 4

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