1 / 37

Pandemia de Influenza: situação e perspectivas

Pandemia de Influenza: situação e perspectivas. Jarbas Barbosa da Silva Jr. Organização Pan-Americana de Saúde (OPAS). Cronologia da pandemia A (H1N1). Cronologia da pandemia A (H1N1). March. April. 10 April: outbreak of ILI in Veracruz. May. June. August. September. July. October.

mervyn
Download Presentation

Pandemia de Influenza: situação e perspectivas

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Pandemia de Influenza: situação e perspectivas Jarbas Barbosa da Silva Jr.Organização Pan-Americana de Saúde (OPAS)

  2. Cronologia da pandemia A (H1N1)

  3. Cronologia da pandemia A (H1N1) March April 10 April: outbreak of ILI in Veracruz May June August September July October

  4. Cronologia da pandemia A (H1N1) April 21 April: 2 cases of H1N1 reported in California, USA 4 April: outbreak of ILI in Veracruz May June August March September July October 23 April: H1N1 confirmed in several patients in MX Source: MMWR, 58(15)

  5. Genesis of the swine-origin influenza A (H1N1) virus North American avian Human (H3N2) Classical swine (derived from the 1918 virus) Eurasian avian-like swine PB2 - North American avian PB1 - Human H3N2 PA - North American avian H1 - Classical swine NP - Classical swine N1 - Eurasian avian-like swine M - Eurasian avian-like swine NS - Classical swine Dawood et al., NEJM, 2009 Garten et al., Science, 2009 Smith et al., Nature, 2009 Influenza A (H1N1) Fig. 4. Neumann et al.

  6. Cronologia da pandemia A (H1N1) April 21 April: 2 cases of H1N1 confirmed in California, USA 27 April: WHO phase 4 4 April: outbreak of ILI in Veracruz May June August March September July October

  7. Cronologia da pandemia A (H1N1) April 21 April: 2 cases of H1N1 confirmed in California, USA 27 April: WHO phase 4 4 April: outbreak of ILI in Veracruz 29 April: WHO phase 5 May June August March September July October

  8. Cronologia da pandemia A (H1N1) May 21 April: 2 cases of H1N1 confirmed in California, USA 27 April: WHO phase 4 4 April: outbreak of ILI in Veracruz 29 April: WHO phase 5 May: H1N1 introduction in SH April June August March September July October H1N1 in 48 countries

  9. Cronologia da pandemia A (H1N1) June 21 April: 2 cases of H1N1 confirmed in California, USA 27 April: WHO phase 4 4 April: outbreak of ILI in Veracruz 29 April: WHO phase 5 11 June: WHO phase 6 pandemicdeclared; H1N1 in 74 countries April May August March September July October

  10. Cronologia da pandemia A (H1N1) June 21 April: 2 cases of H1N1 confirmed in California, USA 4 April: outbreak of ILI in Veracruz 11 June: WHO phase 6 pandemic declared; H1N1 in 74 countries April May August March September July October 1st US H1N1 peak Source: CDC FLUVIEW, http://www.cdc.gov/flu/weekly/

  11. Cronologia da pandemia A (H1N1) July June 21 April: 2 cases of H1N1 confirmed in California, USA Chile H1N1 winter peak 4 April: outbreak of ILI in Veracruz 11 June: WHO phase 6 pandemic declared; H1N1 in 74 countries March April May August September October Argentina H1N1 winter peak

  12. Cronologia da pandemia A (H1N1) June August September July 21 April: 2 cases of H1N1 confirmed in California, USA 4 April: outbreak of ILI in Veracruz 29 April: WHO phase 5 Active Transmission of H1N1 in Tropical Asia and Tropical Americas April May March October

  13. Cronologia da pandemia A (H1N1) August 21 April: 2 cases of H1N1 confirmed in California, USA Wk 26: Chile peak ILI activity 4 April: outbreak of ILI in Veracruz Southern Hemisphere Influenza transmission subsides; Brazil H1N1 winter peak 11 June: WHO phase 6 pandemic declared; H1N1 in 74 countries April May June March September July October Source: WHO FluNet

  14. Cronologia da pandemia A (H1N1) August 2nd H1N1 season begins in the US 21 April: 2 cases of H1N1 confirmed in California, USA 2nd H1N1 season starts in Japan 4 April: outbreak of ILI in Veracruz 11 June: WHO phase 6 pandemic declared; H1N1 in 74 countries April May June March September July October Source: CDC FLUVIEW, http://www.cdc.gov/flu/weekly/

  15. Cronologia da pandemia A (H1N1) September 21 April: 2 cases of H1N1 confirmed in California, USA 27 April: WHO phase 4 4 April: outbreak of ILI in Veracruz 29 April: WHO phase 5 11 June: WHO phase 6 pandemic declared; H1N1 in 74 countries April May June August March July October Wk 30: UK peak ILI activity WK 24: SA H3N2 peak Wk 29: Australia and NZ peak ILI 15-17 April: clusters of severe pneumonia in Mexico Wk 26: Argentina peak ILI activity increase in influenza activity in Mexico 23 April: H1N1 confirmed in several patients in MX Source: Mexico MoH, http://portal.salud.gob.mx/descargas/pdf/influenza/situacion_actual_epidemia_121009.pdf

  16. Cronologia da pandemia A (H1N1) September 27 April: WHO phase 4 29 April: WHO phase 5 Increasing activity throughout Northern Hemisphere 11 June: WHO phase 6 pandemic declared; H1N1 in 74 countries April May June August March July October WK 24: SA H3N2 peak

  17. Cronologia da pandemia A (H1N1) October 27 April: WHO phase 4 29 April: WHO phase 5 Increasing activity throughout Northern Hemisphere 11 June: WHO phase 6 pandemic declared; H1N1 in 74 countries April May June August March September July WK 24: SA H3N2 peak

  18. América do Norte USA CANADA MEXICO

  19. América Central e o Caribe GUATEMALA CAREC CAREC Member countries are : Barbados, Bahamas, Dominica, Jamaica, San Vincent and the Grenadines, and Trinidad y Tobago.

  20. América do Sul Chile Peru Argentina

  21. Principais características da pandemia

  22. O vírus viaja rápido • 213 países e territórios • 16700 mortes

  23. O inverno faz diferença Corredor Endémico de Enfermedad Tipo Influenza. Argentina, SE 35. 2009

  24. 0,8 – 2,4 p/ 105 Mortes 20% UTI 2 – 30 p/105 Hospitalização 5% - 11% ? Taxa de ataque Aspectos epidemiológicos População Assintomáticos?

  25. Características dos casos

  26. Aspectos epidemiológicos • Número Básico de Reprodução (Ro) • Estimado (1.5 - 1.7) • Taxa de Ataque Secundária • Contatos domiciliares • SRA: 19% (US) • ETI: 8-12% (US) • ETI: 4.8-7.6% (Japão) • Surtos em escolas • Casos confirmados em laboratório: 13-33%

  27. O vírus pandêmico substitui o sazonal Distribución porcentual de virus respiratorios por grupos de edad. Argentina, 2009.

  28. Pandemia x Sazonal Age-related distribution of deaths from severe pneumonia compared to influenza seasons 2006-08. Mexico

  29. Pandemia x Sazonal

  30. Hospitalização Taxa de Hospitalização por Influenza em países das Américas

  31. Taxa de Mortalidade Taxa de Mortalidade por Influenza em países das Américas

  32. Influenza Sazonal x Pandemia • Catastrofismo x negligência • Gripe espanhola x gripe comum • Infectividade \ Patogenicidade \ Virulencia • Magnitude \ Transcendência \ Vulnerabilidade

  33. Lições aprendidas Coordenação da resposta Vigilância/RSI /Laboratório Medidas não farmacêuticas/ comunicação de risco Serviços de saúde

  34. Resumo • Maioria dos casos é leve e moderado • Epidemiologicamente diferente da influenza sazonal • “Proteção” dos mais velhos para casos, mas letalidade alta • Hospitalizações e mortes entre crianças, adolescentes e adultos jovens • “Picos” no inverno • Letalidade geral baixa, mortalidade muito diferente entre os países • Dinâmica de transmissão parece semelhante à influenza sazonal

  35. Desafios para o futuro • Novas ondas • Vigilância do vírus • Evidências • RSI(2005)

  36. Os primeiros casos

More Related